| Description : |
Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large subunit possesses a cysteine protease domain, and both subunits possess calcium-binding domains. Calpains have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. The function of the protein encoded by this gene is not known. An orthologue has been found in mouse but it seems to diverge from other family members. The mouse orthologue is thought to be calcium independent with protease activity. [provided by RefSeq, Jul 2008] |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
92.7 kDa |
| AA Sequence : |
MDATALERDAVQFARLAVQRDHEGR YSEAVFYYKEAAQALIYAEMAGSSL ENIQEKITEYLERVQALHSAVQSKS ADPLKSKHQLDLERAHFLVTQAFDE DEKENVEDAIELYTEAVDLCLKTSY ETADKVLQNKLKQLARQALDRAEAL GEPLTKPVGKISSTSVKPKPPPERA HFPLGANPFLERPQSFISPQSCDAQ GQRYTAEEIEVLRTTSKINGIEYVP FMNVDLRERFAYPMPFCDRWGKLPL SPKQKTTFSKWVRPEDLTNNPTMIY TVSSFSIKQTIVSDCSFVASLAISA AYERRFNKKLITGIIYPQNKDGEPE YNPCGKYMVKLHLNGVPRKVIIDDQ LPVDHKGELLCSYSNNKSELWVSLI EKAYMKVMGGYDFPGSNSNIDLHAL TGWIPERIAMHSDSQTFSKDNSFRM LYQRFHKGDVLITASTGMMTEAEGE KWGLVPTHAYAVLDIREFKGLRFIQ LKNPWSHLRWKGRYSENDVENWTPE LQKYLNFDPRTAQKIDNGIFWISWD DLCQYYDVIYLSWNPGLFKESTCIH STWDAKQGPVKDAYSLANNPQYKLE VQCPQGGAAVWVLLSRHITDKDDFA NNREFITMVVYKTDGKKVYYPADPP PYIDGIRINSPHYLTKIKLTTPGTH TFTLVVSQYEKQNTIHYTVRVYSAC SFTFSKIPSPYTLSKRINGKWSGQS AGGCGNFQETHKNNPIYQFHIEKTG PLLIELRGPRQYSVGFEVVTVSTLG DPGPHGFLRKSSGDYRCGFCYLELE NIPSGIFNIIPSTFLPKQEGPFFLD FNSIIPIKITQLQTRTRPLEQKLIS EEDLAANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
