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Capn2

  • Official Full Name

    calpain 2, (m/II) large subunit

  • Overview

    The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene encodes the large subunit of the ubiquitous enzyme, calpain 2. Multiple heterogeneous transcriptional start sites in the 5 UTR have been reported. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
  • Synonyms

    CAPN2; calpain 2, (m/II) large subunit; CANP2; mCANP; CANPL2; CANPml; calpain-2 catalytic subunit; CANP 2; M-calpain; calpain M-type; millimolar-calpain; calpain-2 large subunit; calpain 2, large subunit; calpain large polypeptide L2; calpain, large polypeptide L2; calpain 2, large [catalytic] subunit; calcium-activated neutral proteinase 2;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Native Proteins
  • Bovine
  • Chicken
  • Cynomolgus Monkey
  • Human
  • Mouse
  • Pig
  • Porcine
  • Rat
  • Rhesus Macaque
  • Bovine Myocardium
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mamanlian cells
  • Mammalian Cell
  • Mammalian cells
  • Porcine kidney
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • MYC
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CAPN2-10702H Recombinant Human CAPN2 protein, GST-tagged E.coli GST 1-330 aa
Human CAPN2-27400TH Recombinant Human CAPN2 Wheat Germ N/A 700 amino acids
Human CAPN2-123H Recombinant Human CAPN2, MYC/DDK-tagged HEK293 Myc/DDK
Human CAPN2-122H Recombinant Human CAPN2 protein, His-tagged E.coli His 20-700 aa
Human CAPN2-0363H Recombinant Human CAPN2 Protein, GST-Tagged Wheat Germ GST
Human CAPN2-7863HCL Recombinant Human CAPN2 293 Cell Lysate HEK293 N/A
Human CAPN2-3550H Recombinant Human CAPN2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human CAPN2-115HFL Recombinant Full Length Human CAPN2 Protein, C-Flag-tagged Mammalian cells Flag
Human CAPN2-587H Recombinant Human CAPN2 Protein, His-tagged E.coli His Leu45~Asp514
Human CAPN2-496H-B Recombinant Human CAPN2 Protein Pre-coupled Magnetic Beads HEK293
Human CAPN2-3918HFL Recombinant Full Length Human CAPN2, Flag-tagged Mamanlian cells Flag
Human CAPN2-496H Recombinant Human CAPN2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human CAPN2-49HF Recombinant Full Length Human CAPN2 Protein In Vitro Cell Free System 700 amino acids
Human CAPN2-2820HF Recombinant Full Length Human CAPN2 Protein, GST-tagged In Vitro Cell Free System GST 700 amino acids
Mouse CAPN2-2694M Recombinant Mouse CAPN2 Protein Mammalian Cell His
Mouse CAPN2-1216M Recombinant Mouse CAPN2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Capn2-362M Recombinant Mouse Capn2 Protein, GST-tagged E.coli N-GST Glu33-Thr344
Mouse Capn2-759M Recombinant Mouse Capn2 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse CAPN2-1216M-B Recombinant Mouse CAPN2 Protein Pre-coupled Magnetic Beads HEK293
Rat CAPN2-1121R Recombinant Rat CAPN2 Protein Mammalian Cell His
Rat CAPN2-785R Recombinant Rat CAPN2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat CAPN2-785R-B Recombinant Rat CAPN2 Protein Pre-coupled Magnetic Beads HEK293
Bovine CAPN2-350B Native Bovine CAPN2 Bovine Myocardium N/A
Cynomolgus Monkey CAPN2-358C Recombinant Cynomolgus CAPN2 Protein, His-tagged Mammalian Cell His
Cynomolgus Monkey CAPN2-106C-B Recombinant Cynomolgus Monkey CAPN2 Protein Pre-coupled Magnetic Beads HEK293
Cynomolgus Monkey CAPN2-106C Recombinant Cynomolgus Monkey CAPN2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Porcine CAPN2-22P Active Native Porcine CAPN2 protein Porcine kidney N/A
Rhesus Macaque CAPN2-625R Recombinant Rhesus monkey CAPN2 Protein, His-tagged Mammalian Cell His
Rhesus Macaque CAPN2-453R Recombinant Rhesus Macaque CAPN2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque CAPN2-453R-B Recombinant Rhesus Macaque CAPN2 Protein Pre-coupled Magnetic Beads HEK293
Pig CAPN2-001P Recombinant Pig CAPN2 Protein, His-tagged E.coli His
Chicken CAPN2-6637C Recombinant Chicken CAPN2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

Capn2 involved in several pathways and played different roles in them. We selected most pathways Capn2 participated on our site, such as Protein processing in endoplasmic reticulum, Apoptosis, Focal adhesion, which may be useful for your reference. Also, other proteins which involved in the same pathway with Capn2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Protein processing in endoplasmic reticulumPLAA;SSR3;UBE2G1;PDIP5;ATF6;MAPK8B;UBE2D2;DNAJB12A;MAN1A1
ApoptosisBIRC2;PRKAR2AB;RIPK1;ADD1;SPNA2;CDKN2A;HIST1H1A;DCC;CYCSB
Focal adhesionGRB2A;ITGB1;MAPK4;COL5A2A;PRKCBB;RAP1AA;MAPK6;COL6A4;COL4A1
Alzheimers diseaseNDUFA4L2;MAPT;ATP5A1;COX8A;PSENEN;CYCS;NDUFS1;MT-ATP6;CALM3

Capn2 has several biochemical functions, for example, calcium ion binding, calcium-dependent cysteine-type endopeptidase activity, cysteine-type peptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Capn2 itself. We selected most functions Capn2 had, and list some proteins which have the same functions with Capn2. You can find most of the proteins on our site.

Function Related Protein
calcium ion bindingPCDHGA12;KCNIP2;ITPR3;PCDH15;CDH12;GUCA1D;PPP3R1B;TNNC1;PRRG1
calcium-dependent cysteine-type endopeptidase activityCAPNS1;CAPN13;PEF1;SOLH;CAPN1A;CAPN2L;CAPN1B;CAPN3;CAPN2
cysteine-type peptidase activityCLCA5;CTSK;USP17L3;CASP6L1;OTUD4;USP43A;CAPN8;CASPBL;CTSL1
cytoskeletal protein bindingFLNC;FARP2;MSNB;FABP3;CAPN1;PACSIN1;B4GALT1;TNNT2A;NF2B
protein bindingSUMO2;PLK1S1;RPUSD3;MAP3K1;UBXN4;CHN2;EIF3H;ISOC2;CALCA
protein heterodimerization activityYWHAH;SOX5;HIST3H2A;MYF6;HIST1H2BK;APITD1;SRI;SAE1;PANX2

Capn2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Capn2 here. Most of them are supplied by our site. Hope this information will be useful for your research of Capn2.

CAPNS1; ZDHHC17; PTPN1; TNS1; CAST; NMT1; SUMO1; 15-deoxy-delta(12,14; JAK3; CHORDC1

  • Q&As
  • Reviews

Q&As (5)

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How is CAPN2 protein expression regulated in normal physiological conditions? 10/15/2021

CAPN2 activity is tightly regulated by intracellular calcium levels and various other factors to maintain cellular homeostasis.

How does CAPN2 protein interact with other molecules or proteins in disease contexts? 03/10/2021

CAPN2 interacts with various cellular proteins, contributing to processes like protein degradation, cytoskeletal remodeling, and cell signaling, influencing disease pathways.

Can CAPN2 protein serve as a potential therapeutic target? 01/02/2018

Research suggests that modulating CAPN2 activity could be a potential therapeutic strategy for managing diseases associated with its dysregulation.

Are there any drugs or compounds known to modulate CAPN2 activity? 07/17/2017

Some compounds and inhibitors targeting CAPN2 have been developed in preclinical studies, showing promise in controlling its activity for therapeutic purposes.

Can CAPN2 protein levels serve as a biomarker for certain diseases? 06/07/2017

In some cases, altered levels of CAPN2 have been observed in disease states, suggesting its potential as a biomarker, but further validation is needed.

Customer Reviews (3)

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Reviews
03/05/2020

    The CAPN2 protein has been extensively studied and validated in various experimental applications.

    08/03/2019

      Their team of technical experts possess deep knowledge and expertise regarding the protein, ensuring that researchers receive accurate and timely assistance.

      10/01/2017

        In addition to its advantages in trials, the manufacturer of the CAPN2 protein offers exceptional support to researchers.

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