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Official Full Name calpain 3, (p94)
Background Calpain, a heterodimer consisting of a large and a small subunit, is a major intracellular protease, although its function has not been well established. This gene encodes a muscle-specific member of the calpain large subunit family that specifically binds to titin. Mutations in this gene are associated with limb-girdle muscular dystrophies type 2A. Alternate promoters and alternative splicing result in multiple transcript variants encoding different isoforms and some variants are ubiquitously expressed. [provided by RefSeq, Jul 2008]
Synonyms CAPN3; calpain 3, (p94); p94; CANP3; LGMD2; nCL-1; CANPL3; LGMD2A; calpain-3; calpain L3; new calpain 1; calpain, large polypeptide L3; calcium-activated neutral proteinase 3; calpain p94, large [catalytic] subunit; muscle-specific calcium-activated neutral protease 3 large subunit;
    • Species :
    • Chicken
    • Cynomolgus Monkey
    • Human
    • Rat
    • Source :
    • E. coli
    • E.coli
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CAPN3-22H Recombinant Human CAPN3 Protein, His-tagged E. coli His
    Human CAPN3-26374TH Recombinant Human CAPN3, His-tagged E.coli His
    Human CAPN3-263H Recombinant Human CAPN3 protein, His-tagged E. coli His
    Human CAPN3-27209TH Recombinant Human CAPN3 Protein, GST-tagged Wheat Germ GST
    Human CAPN3-272H Recombinant Human CAPN3 protein, GST-tagged E. coli GST
    Human CAPN3-27402TH Recombinant Human CAPN3 Wheat Germ N/A
    Human CAPN3-31H Recombinant Human CAPN3 protein E.coli N/A
    Human CAPN3-7862HCL Recombinant Human CAPN3 293 Cell Lysate HEK293 N/A
    Rat CAPN3-1122R Recombinant Rat CAPN3 Protein Mammalian Cell His
    Cynomolgus Monkey CAPN3-359C Recombinant Cynomolgus CAPN3 Protein, His-tagged Mammalian Cell His
    Chicken CAPN3-1223C Recombinant Chicken CAPN3 Mammalian Cell His

    capn3 involved in several pathways and played different roles in them. We selected most pathways capn3 participated on our site, such as Integrin-mediated cell adhesion, TNF-alpha/NF-kB Signaling Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with capn3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Integrin-mediated cell adhesion SEPP1; MAPK4; CAPNS1; CAPN3; CAPN11; CAPN5; CAPN10; MAPK6; CAPN3A; SEPP1A
    TNF-alpha/NF-kB Signaling Pathway FAF1; TNIP1; CRADD; KTN1; UNC5CL; ZFAND5; DPF2; PFDN2; COMMD1; NKIRAS1

    capn3 has several biochemical functions, for example, calcium ion binding, calcium-dependent cysteine-type endopeptidase activity, catalytic activity. Some of the functions are cooperated with other proteins, some of the functions could acted by capn3 itself. We selected most functions capn3 had, and list some proteins which have the same functions with capn3. You can find most of the proteins on our site.

    Function Related Protein
    calcium ion binding SYT5B; CPNE1; FAT3A; PCDHB7; PLCG1; PLA2G4B; ATP2A2; SDF4; PCDH2G17; EFCAB4A
    calcium-dependent cysteine-type endopeptidase activity CAPNS1A; SOLH; SRI; PEF1; CAPN5; CAPN9; CAPN1; CAPN11; CAPN2L; CAPN2A
    catalytic activity EML5; PPM1AA; LYZ1; ALDOCA; AOAH; ISOC2B; AOX3; AGXT2; ALDOAB; CKBB
    cysteine-type peptidase activity CAPN2B; CTSC; CAPN12; CTSL1B; USP43A; CASPB; CASP6L2; CTSH; CLCA5; CAPN2A
    ligase regulator activity CAPN3
    protein binding LIPT2; RABIF; PRH2; BCL2L1; BIN1; HBP1; FHL2; EIF3D; GSG1; KCNJ9
    protein complex scaffold WWC1; ISCU; MPP7; DLG1; SEPT2; HOMER1; AKAP13; SLC9A1; CAPN3; MAGI1B
    signal transducer activity STAT4; OLFR507; PRMT2; RGS7; PLK2; GRM2A; GPR113; GNB1; TACR1B; OPN1MW4
    sodium ion binding SLC24A4; PDXK; SLC24A4A; ATP1A1; SLC24A1; CAPN3; SLC24A2; SLC24A5; SCN9A; SLC34A2
    structural constituent of muscle MYL2; COX4I2; ACTN3; MYBPH; ACTN2; TPM4; PLEC; TPM2; MYBPC3; DAG1
    titin binding ANKRD1; MYBPC3; CAMK2D; SLC14A2; CALM3; ANKRD1B; CAPN3; CALM; ANKRD2; CALM1

    capn3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with capn3 here. Most of them are supplied by our site. Hope this information will be useful for your research of capn3.


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