Recombinant Human NECTIN1 Protein, Gln31-Thr334, C-His-Avi tagged, Biotinylated

• Cat.No.: NECTIN1-188H
• Product Overview: Recombinant human Nectin-1/PVRL1/CD111-C-His-Avi protein was developed from HEK293 and has a target region of C-His-Avi.

Specification

• Description: This gene encodes an adhesion protein that plays a role in the organization of adherens junctions and tight junctions in epithelial and endothelial cells. The protein is a calcium(2+)-independent cell-cell adhesion molecule that belongs to the immunoglobulin superfamily and has 3 extracellular immunoglobulin-like loops, a single transmembrane domain (in some isoforms), and a cytoplasmic region. This protein acts as a receptor for glycoprotein D (gD) of herpes simplex viruses 1 and 2 (HSV-1, HSV-2), and pseudorabies virus (PRV) and mediates viral entry into epithelial and neuronal cells. Mutations in this gene cause cleft lip and palate/ectodermal dysplasia 1 syndrome (CLPED1) as well as non-syndromic cleft lip with or without cleft palate (CL/P). Alternative splicing results in multiple transcript variants encoding proteins with distinct C-termini.
• Source: HEK293
• Species: Human
• Tag: C-His-Avi
• Protein length: Gln31-Thr334
• Conjugation/Label: Biotin
• Form: Lyophilised
• Endotoxin: Endotoxin level was found to be less than 0.1 ng/μg (1 EU/μg).
• Notes: FOR RESEARCH USE ONLY (RUO).
• Storage: The lyophilized protein is stable for at least 1 year from date of receipt at -20 centigrade.
• Storage Buffer: Lyophilised from 0.2 μm filtered PBS solution pH 7.4. Upon receipt centrifuge vial to ensure maximal product extraction, recommended: 20 sec, 5K RPM

Gene Information

• Gene Name: NECTIN1 nectin cell adhesion molecule 1 [ Homo sapiens (human) ]
• Official Symbol: NECTIN1
• Synonyms: NECTIN1; nectin cell adhesion molecule 1; ED4; PRR; HIgR; HV1S; HVEC; OFC7; PRR1; PVRR; CD111; PVRL1; PVRR1; SK-12; CLPED1; nectin-1; nectin-1; ectodermal dysplasia 4 (Margarita Island type); herpes simplex virus type 1 sensitivity; herpes virus entry mediator C; herpesvirus Ig-like receptor; nectin 1; poliovirus receptor-like 1; poliovirus receptor-related 1 (herpesvirus entry mediator C); poliovirus receptor-related protein 1
• Gene ID: 5818
• mRNA Refseq: NM_002855
• Protein Refseq: NP_002846
• MIM: 600644
• UniProt ID: Q15223