| Description : |
This gene encodes an adhesion protein that plays a role in the organization of adherens junctions and tight junctions in epithelial and endothelial cells. The protein is a calcium(2+)-independent cell-cell adhesion molecule that belongs to the immunoglobulin superfamily and has 3 extracellular immunoglobulin-like loops, a single transmembrane domain (in some isoforms), and a cytoplasmic region. This protein acts as a receptor for glycoprotein D (gD) of herpes simplex viruses 1 and 2 (HSV-1, HSV-2), and pseudorabies virus (PRV) and mediates viral entry into epithelial and neuronal cells. Mutations in this gene cause cleft lip and palate/ectodermal dysplasia 1 syndrome (CLPED1) as well as non-syndromic cleft lip with or without cleft palate (CL/P). Alternative splicing results in multiple transcript variants encoding proteins with distinct C-termini. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
His |
| Form : |
Lyophilized |
| Molecular Mass : |
34.8 kDa |
| Protein Length : |
517 |
| AA Sequence : |
MARMGLAGAAGRWWGLALGLTAFFL PGVHSQVVQVNDSMYGFIGTDVVLH CSFANPLPSVKITQVTWQKSTNGSK QNVAIYNPSMGVSVLAPYRERVEFL RPSFTDGTIRLSRLELEDEGVYICE FATFPTGNRESQLNLTVMAKPTNWI EGTQAVLRAKKGQDDKVLVATCTSA NGKPPSVVSWETRLKGEAEYQEIRN PNGTVTVISRYRLVPSREAHQQSLA CIVNYHMDRFKESLTLNVQYEPEVT IEGFDGNWYLQRMDVKLTCKADANP PATEYHWTTLNGSLPKGVEAQNRTL FFKGPINYSLAGTYICEATNPIGTR SGQVEVNITEFPYTPSPPEHGRRAG PVPTAIIGGVAGSILLVLIVVGGIV VALRRRRHTFKGDYSTKKHVYGNGY SKAGIPQHHPPMAQNLQYPDDSDDE KKAGPLGGSSYEEEEEEEEGGGGGE RKVGGPHPKYDEDAKRPYFTVDEAE ARQDGYGDRTLGYQYDPEQLDLAEN MVSQNDGSFISKKEWYV |
| Purity : |
> 98% |
| Applications : |
WB; ELISA; FACS; FC |
| Stability : |
This bioreagent is stable at 4 centigrade (short-term) and -70 centigrade(long-term). After reconstitution, sample may be stored at 4 centigrade for 2-7 days and below -18 centigrade for future use. |
| Storage : |
At -20 centigrade. |
| Concentration : |
1 mg/mL |
| Storage Buffer : |
PBS (pH 7.4-7.5). Sterile-filtered colorless solution. |
| Reconstitution : |
Reconstitute in sterile distilled H2O to no less than 100 μg/mL; dilute reconstituted stock further in other aqueous solutions if needed. Please review COA for lot-specific instructions. Final measurements should be determined by the end-user for optimal performance. |
