Recombinant Human PPARA protein, His-tagged

• Cat.No.: PPARA-236H
• Product Overview: Recombinant Human PPARA fused with His tag at N-terminal was expressed in Insect cells.

Specification

• Description: Peroxisome proliferators include hypolipidemic drugs, herbicides, leukotriene antagonists, and plasticizers; this term arises because they induce an increase in the size and number of peroxisomes. Peroxisomes are subcellular organelles found in plants and animals that contain enzymes for respiration and for cholesterol and lipid metabolism. The action of peroxisome proliferators is thought to be mediated via specific receptors, called PPARs, which belong to the steroid hormone receptor superfamily. PPARs affect the expression of target genes involved in cell proliferation, cell differentiation and in immune and inflammation responses. Three closely related subtypes (alpha, beta/delta, and gamma) have been identified. This gene encodes the subtype PPAR-alpha, which is a nuclear transcription factor. Multiple alternatively spliced transcript variants have been described for this gene, although the full-length nature of only two has been determined.
• Source: E.coli
• Species: Human
• Tag: His
• Form: 50mM Tris, 8M Urea, pH8.0.
• Molecular Mass: 52 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: >50 ug/mL as determined by microplate BCA method

Gene Information

• Gene Name: PPARA peroxisome proliferator-activated receptor alpha [ Homo sapiens ]
• Official Symbol: PPARA
• Synonyms: PPARA; peroxisome proliferator-activated receptor alpha; peroxisome proliferative activated receptor, alpha , PPAR; hPPAR; NR1C1; PPAR-alpha; nuclear receptor subfamily 1 group C member 1; peroxisome proliferative activated receptor, alpha; peroxisome proliferator-activated nuclear receptor alpha variant 3; PPAR; PPARalpha; MGC2237; MGC2452
• Gene ID: 5465
• mRNA Refseq: NM_001001928
• Protein Refseq: NP_001001928
• UniProt ID: Q07869

Reviews

03/21/2018

Their expertise and responsiveness exemplify their dedication to assisting customers, offering solutions and guidance whenever challenges arise.

01/17/2018

The combination of the protein's exceptional characteristics and the manufacturer's outstanding technical assistance equips me with the necessary resources to overcome potential hurdles and achieve groundbreaking results.

02/26/2017

Its impressive purity and functional properties make it an ideal choice for my research, ensuring precise and accurate results.

Q&As

How does PPARA affect lipid metabolism?

PPARA enhances the breakdown of fatty acids and promotes their oxidation, thereby playing a key role in lipid metabolism.

Are there any PPARA-targeted drugs available?

Yes, fibrates are a class of drugs that act as PPARA agonists and are used to treat conditions such as hyperlipidemia.

Can PPARA activation be beneficial in neurodegenerative diseases?

Some research suggests that PPARA activation may have neuroprotective effects and could be explored as a therapeutic avenue for neurodegenerative diseases.

In what tissues is PPARA predominantly expressed?

PPARA is predominantly expressed in tissues with high energy expenditure, such as the liver, heart, and skeletal muscle.

Can PPARA activation be targeted for treating dyslipidemia?

Yes, PPARA agonists have been investigated as potential therapeutic agents for managing dyslipidemia by promoting lipid metabolism.