Active Recombinant Human RSPO3 Protein

• Cat.No.: RSPO3-442H
• Product Overview: Recombinant Human RSPO3 was expressed in CHO cells.

Specification

• Description: This gene belongs to the R-spondin family. The encoded protein plays a role in the regulation of Wnt (wingless-type MMTV integration site family)/beta-catenin and Wnt/planar cell polarity (PCP) signaling pathways, which are involved in development, cell growth and disease pathogenesis. Genome-wide association studies suggest a correlation of this gene with bone mineral density and risk of fracture. This gene may be involved in tumor development.
• Source: CHO cells
• Species: Human
• Form: Lyophilized from a 0.2 µM filtered solution of 20mM phosphate buffer, 100mM NaCl, pH 7.2
• Bio-activity: R-Spondin-3 enhances BMP-2 mediated differentiation of MC3T3-E1 cells.
• Molecular Mass: 26.9 kDa
• AA Sequence: MHPNVSQGCQGGCATCSDYNGCLSC KPRLFFALERIGMKQIGVCLSSCPS GYYGTRYPDINKCTKCKADCDTCFN KNFCTKCKSGFYLHLGKCLDNCPEG LEANNHTMECVSIVHCEVSEWNPWS PCTKKGKTCGFKRGTETRVREIIQH PSAKGNLCPPTNETRKCTVQRKKCQ KGERGKKGRERKRKKPNKGESKEAI PDSKSLESSKEIPEQRENKQQQKKR KVQDKQKSVSVSTVH
• Endotoxin: Endotoxin level is <0.1 ng/µg of protein (<1EU/µg).
• Purity: >95% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: Resuspend the protein in the desired concentration in proper buffer

Gene Information

• Gene Name: RSPO3 R-spondin 3 [ Homo sapiens ]
• Official Symbol: RSPO3
• Synonyms: RSPO3; R-spondin 3; R spondin 3 homolog (Xenopus laevis) , thrombospondin, type I, domain containing 2 , THSD2; R-spondin-3; FLJ14440; R-spondin 3 homolog; roof plate-specific spondin-3; protein with TSP type-1 repeat; thrombospondin, type I, domain containing 2; thrombospondin type-1 domain-containing protein 2; PWTSR; THSD2; CRISTIN1
• Gene ID: 84870
• mRNA Refseq: NM_032784
• Protein Refseq: NP_116173
• MIM: 610574
• UniProt ID: Q9BXY4