RSPO3
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Official Full Name
R-spondin 3
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Synonyms
RSPO3; R-spondin 3; R spondin 3 homolog (Xenopus laevis) , thrombospondin, type I, domain containing 2 , THSD2; R-spondin-3; FLJ14440; R-spondin 3 homolog; roof plate-specific spondin-3; protein with TSP type-1 repeat; thrombospondin, type I, domain cont;
- Recombinant Proteins
- Cell & Tissue Lysates
- Human
- Mouse
- Zebrafish
- CHO
- E.coli
- HEK293
- Human Cell
- Mammalian Cell
- Mammalian cells
- C
- His
- Fc
- Fc|His
- GST
- His|T7
- N/A
- N
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | RSPO3-442H | Active Recombinant Human RSPO3 Protein | CHO | N/A |
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| Human | RSPO3-2455H | Recombinant Human RSPO3, GST-tagged | E.coli | GST | 27-272aa | |
| Human | RSPO3-3883H | Active Recombinant Human RSPO3 protein, His-tagged | HEK293 | His | Met 1-Val 146 | |
| Human | RSPO3-441H | Recombinant Human RSPO3 Protein, Fc/His-tagged | HEK293 | Fc/His |
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| Human | RSPO3-1906HCL | Recombinant Human RSPO3 cell lysate | Human Cell | N/A |
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| Human | RSPO3-0654H | Active Recombinant Human RSPO3 protein, Fc-tagged | HEK293 | Fc | Gln22-His272 |
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| Human | RSPO3-1946H | Recombinant Human RSPO3 protein, His & T7-tagged | E.coli | His/T7 | Gln22~His272 (Accession # Q9BXY4) |
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| Human | RSPO3-6636H | Recombinant Human RSPO3 Protein (Gln22-His272), C-His tagged | Mammalian cells | C-His | Gln22-His272 |
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| Human | RSPO3-35H | Recombinant Human RSPO3 Protein | E.coli |
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| Human | RSPO3-423H | Recombinant Human RSPO3 Protein, His-tagged | HEK293 | His | 272 |
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| Human | RSPO3-6637H | Recombinant Human RSPO3 Protein (Gly27-His272), N-His tagged | E.coli | N-His | Gly27-His272 |
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| Mouse | RSPO3-14554M | Active Recombinant Mouse RSPO3 Protein | CHO |
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| Zebrafish | RSPO3-2315Z | Recombinant Zebrafish RSPO3 | Mammalian Cell | His |
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- Involved Pathway
- Protein Function
- Interacting Protein
- RSPO3 Related Research Area
- RSPO3 Related Signal Pathway
RSPO3 involved in several pathways and played different roles in them. We selected most pathways RSPO3 participated on our site, such as Regulation of FZD by ubiquitination, Signal Transduction, Signaling by Wnt, which may be useful for your reference. Also, other proteins which involved in the same pathway with RSPO3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Regulation of FZD by ubiquitination | RSPO4;FMNL3;ZNRF3;RSPO2;LGR5;RNF43;RSPO3;RSPO1;LGR6 |
| Signal Transduction | RSPO3;NPSR1;GRK7;RSPO2;SKILB;NMBA;OR52B4;MLN;APOA4A |
| Signaling by Wnt | LGR5;RSPO2;AES;HECW1B;TMED5;PYGO1;CDC73;SOX9A;PRICKLE1B |
| TCF dependent signaling in response to WNT | TLE3B;C;RSPO3;SOX9A;LGR6;BCL9;LEO1;SOX9B;KLHL12 |
RSPO3 has several biochemical functions, for example, G-protein coupled receptor binding, frizzled binding, heparin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RSPO3 itself. We selected most functions RSPO3 had, and list some proteins which have the same functions with RSPO3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| G-protein coupled receptor binding | GNA13A;NMS;HSPA1B;GPRC5B;RSPO1;GNAL;SFTPBB;PSAP;ARRB2 |
| frizzled binding | SFRP1;DVL3;DVL1B;RNF43;BAMBI;DVL2;WNT8A;WNT6;WNT2BB |
| heparin binding | ITGAM;AAMP;CECR1;APPA;PLA2G2D;CFH;FGFRL1;RSPO4;SLIT1A |
| receptor binding | PRDX5;TMED1;MCHR1;FGF1B;IDH1;FGF8A;Fgf15;TNFSF12;HFE2 |
RSPO3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RSPO3 here. Most of them are supplied by our site. Hope this information will be useful for your research of RSPO3.
lgr4; EEA1
- Q&As
- Reviews
Q&As (7)
Ask a questionGenetic mutations in RSPO3 can disrupt normal development and tissue regeneration.
Targeting RSPO3 could offer advances in regenerative medicine and cancer therapy by modulating Wnt signaling.
RSPO3 plays a significant role in maintaining stem cell populations and influencing their differentiation.
It stimulates tissue development and regeneration by activating Wnt pathways, essential for cellular proliferation.
RSPO3, a member of the R-spondin family, enhances Wnt signaling, crucial for cellular growth and differentiation.
Altered RSPO3 activity is linked to cancer development and progression, particularly in colorectal cancer.
RSPO3 interacts synergistically with Wnt pathway components, amplifying signal transduction.
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