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Recombinant Human Grancalcin, EF-hand Calcium Binding Protein, His-tagged

Cat.No.: GCA-6903H
Product Overview: Recombinant human GCA protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography. MW: 26.1 kDa.
Description: GCA, also known as Grancalcin, is calcium-binding protein that is especially abundant in human neutrophils. It belongs to the penta EF-hand (PEF) subfamily of EF-hand proteins, which also comprises calpain, sorcin, peflin, and ALG-2. This protein undergoes important conformational changes upon binding of calcium, which subsequently exposes hydrophobic amino acid residues, which direct the protein to hydrophobic surfaces. It interacts with L-plastin, a protein known to have actin bundling activity, which suggests that GCA may play a role in the regulation of neutrophils adhesion.
Source: E. coli
Species: Human
Tag: His
Form: Liquid. 20mM Tris-HCl buffer (pH8.0) containing 20% glycerol 0.1M NaCl.
Molecular Mass: 26.1 kDa (237aa), confirmed by MALDI-TOF
Protein length: 1-217aa
AA Sequence: MGSSHHHHHH SSGLVPRGSH MAYPGYGGGF GNFS IQVPGM QMGQPVPETG PAILLDGYSG PAYSDTYSSA GDSVYTYFSA VAGQDGEVDA EELQRCLTQS GINGTYSPFS LETCRIMIAM LDRDHTGKMG FNAFKELWAA LNAWKENFMT VDQDGSGTVE HHELRQAIGL MGYRLSPQTL TTIVKRYSKN GRIFFDDYVA CCVKLRALTD FFRKRDHLQQ GSANFIYDDF LQGTMAI
Purity: >95% by SDS-PAGE
Applications: SDS-PAGE
Storage: Can be stored at 4℃ short term (1-2 weeks). For long term storage, aliquot and store at -20℃ or -70℃. Avoid repeated freezing and thawing cycles.
Concentration: 1.0 mg/ml (determined by Bradford assay)
Gene Name: GCA grancalcin, EF-hand calcium binding protein [ Homo sapiens ]
Official Symbol: GCA
Synonyms: GCA; grancalcin, EF-hand calcium binding protein; grancalcin, EF hand calcium binding protein; grancalcin; GCL; grancalcin, penta-EF-hand protein; grancalcin, EF-hand calcium-binding protein;
Gene ID: 25801
mRNA Refseq: NM_012198
Protein Refseq: NP_036330
MIM: 607030
UniProt ID: P28676
Chromosome Location: 2p14-q14.3
Function: calcium ion binding; protein homodimerization activity;

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