"INS" Related Products

Recombinant Human INS, His-tagged

Cat.No.: INS-88H
Product Overview: Recombinant Human INS(Phe25-Asn110), fused with an N-terminal Met, 6-His tag and Lys, was expressed in E. coli.
Description: After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5'' region and with the IGF2 gene at the 3'' region. Alternative splicing results in multiple transcript variants.
Source: E. coli
Species: Human
Tag: His
Predicted N Terminal: Met
Form: Lyophilized from a 0.2 μm filtered solution in PBS.
Bio-activity: Measured in a serum-free cell proliferation assay using MCF 7 human breast cancer cells.
Molecular Mass: Predicted Molecular Mass: 10.5 kDaSDS-PAGE: 9 kDa, reducing conditions
Endotoxin: < 1.0 EU per 1 μg of the protein by the LAL method.
Purity: >95%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Storage: Avoid repeated freeze-thaw cycles.12 months from date of receipt, -20 to -70 °C as supplied.1 month, 2 to 8 °C under sterile conditions after reconstitution.3 months, -20 to -70 °C under sterile conditions after reconstitution.
Reconstitution: Reconstitute at 100 μg/mL in sterile PBS.
Gene Name: INS insulin [ Homo sapiens (human) ]
Official Symbol: INS
Synonyms: INS; ILPR; IRDN; IDDM1; IDDM2; MODY10; insulin; proinsulin; preproinsulin; insulin-dependent diabetes mellitus 2
Gene ID: 3630
mRNA Refseq: NM_000207
Protein Refseq: NP_000198
MIM: 176730
UniProt ID: P01308
Chromosome Location: 11p15.5
Pathway: AGE/RAGE pathway; Aldosterone-regulated sodium reabsorption; Cardiac Progenitor Differentiation
Function: hormone activity; identical protein binding; insulin-like growth factor receptor binding

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