Cat.No.:	ICOS-1533H
Product Overview:	The extracellular domain of human CD278 [ICOS] (NP_036224.1) (Glu21-Leu139) is fused to the N-terminus of the Fc region of human IgG1 was expressed in CHO cell.
Description:	The protein encoded by this gene belongs to the CD28 and CTLA-4 cell-surface receptor family. It forms homodimersand plays an important role in cell-cell signaling, immune responses, and regulation of cell proliferation.
Source:	CHO cells
Species:	Human
Tag:	HIgG1 Fc-tagged
Form:	Lyophilized from 0.2μm-filtered solution in PBS.
Bio-activity:	Measured by its ability to inhibit human T cell proliferation induced by rhB7-H2/Fc Chimera in the presence of anti-CD3.
Molecular Mass:	40 KDa (monomer)
AA Sequence:	Glu21-Leu139
Endotoxin:	<0.06 eu/μg as determined by lal>
Purity:	>98%, by SDS-PAGE under reducing conditions.
Stability:	Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
Reconstitution:	Reconstitute at 100μg/ml in sterile PBS.
Warning:	Avoid freeze/thaw cycles.

Gene Name:	ICOS inducible T-cell co-stimulator [ Homo sapiens ]
Official Symbol:	ICOS
Synonyms:	ICOS; inducible T-cell co-stimulator; inducible T-cell costimulator; activation inducible lymphocyte immunomediatory molecule; AILIM; CD278; inducible costimulator; activation-inducible lymphocyte immunomediatory molecule; CVID1; MGC39850;
Gene ID:	29851
mRNA Refseq:	NM_012092
Protein Refseq:	NP_036224
MIM:	604558
UniProt ID:	Q9Y6W8
Chromosome Location:	2q33
Pathway:	Adaptive Immune System, organism-specific biosystem; Cell adhesion molecules (CAMs), organism-specific biosystem; Cell adhesion molecules (CAMs), conserved biosystem; Costimulation by the CD28 family, organism-specific biosystem; Immune System, organism-specific biosystem; Intestinal immune network for IgA production, organism-specific biosystem; Intestinal immune network for IgA production, conserved biosystem;

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