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Official Full Name inducible T-cell co-stimulator
Background The protein encoded by this gene belongs to the CD28 and CTLA-4 cell-surface receptor family. It forms homodimers and plays an important role in cell-cell signaling, immune responses, and regulation of cell proliferation.
Synonyms ICOS; inducible T-cell co-stimulator; inducible T-cell costimulator; activation inducible lymphocyte immunomediatory molecule; AILIM; CD278; inducible costimulator; activation-inducible lymphocyte immunomediatory molecule; CVID1; MGC39850
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Rhesus
    • Rhesus Macaque
    • Rhesus monkey
    • Source :
    • CHO
    • E.coli
    • HEK293
    • Human Cell
    • Human Cells
    • Mammalian Cell
    • NSO
    • Sf21 Insect Cell
    • Tag :
    • Fc
    • His
    • hIgG1
    • hIgG4
    • GST
    • His-Avi
    • HlgG1 Fc
    • human
    • IgG1
    • N/A
    • rFc
    • RlgG Fc
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human ICOS-152H Recombinant Human ICOS Protein, His-tagged Human Cells His
    Human ICOS-101HG GMP Recombinant Human ICOS protein, Fc-tagged HEK293 Fc
    Human ICOS-1531H Recombinant Human ICOS, MIgG2a Fc-tagged CHO Fc
    Human ICOS-1532H Recombinant Human ICOS, HIgG1 Fc-tagged, mutant CHO Fc
    Human ICOS-1533H Recombinant Human ICOS, HIgG1 Fc-tagged CHO Fc
    Human ICOS-1628H Recombinant Human ICOS protein NSO N/A
    Human ICOS-175H Recombinant Human ICOS Protein, Fc/His-tagged HEK293 Fc/His
    Human ICOS-185H Recombinant Human ICOS, Fc-tagged CHO Fc
    Human ICOS-2444HCL Recombinant Human ICOS cell lysate Human Cell N/A
    Human ICOS-3243H Recombinant Human ICOS, Fc-His tagged Human Cell Fc/His
    Human ICOS-3244H Recombinant Human ICOS protein, Fc-tagged HEK293 human/IgG1/Fc
    Human ICOS-3245H Recombinant Human ICOS protein (Met1-Phe141), rFc-tagged HEK293 rFc
    Human ICOS-378H Recombinant Human ICOS (C136S, C137S) protein, His-tagged HEK293 His
    Human ICOS-390H Recombinant Human ICOS protein HEK293 N/A
    Human ICOS-7659H Recombinant Human ICOS protein, His & GST-tagged E.coli His/GST
    Human ICOS-968H Recombinant Human ICOS protein, His-Avi-tagged HEK293 His-Avi
    Mouse ICOS-1724MCL Recombinant Mouse ICOS cell lysate Human Cell N/A
    Mouse Icos-1747M Recombinant Mouse Inducible T-cell Co-stimulator Sf21 Insect Cell N/A
    Mouse Icos-1821M Recombinant Mouse Icos, MIgG2a Fc-tagged CHO Fc
    Mouse ICOS-2711M Recombinant Mouse ICOS protein (C137S, C138S), His-tagged HEK293 His
    Mouse Icos-33M Recombinant Mouse Icos protein, His-tagged E.coli His
    Mouse Icos-6951M Recombinant Mouse Icos, Fc tagged Human Cell Fc
    Mouse ICOS-729M Recombinant Mouse ICOS protein (C137S, C138S), Fc-tagged HEK293 human/IgG1/Fc
    Mouse ICOS-827M Recombinant Mouse ICOS Protein (Met1-Leu144), RlgG Fc-tagged HEK293 RlgG Fc
    Rat ICOS-1195RCL Recombinant Rat ICOS cell lysate Human Cell N/A
    Rat ICOS-2981R Recombinant Rat ICOS Protein Mammalian Cell His
    Rat Icos-7660R Recombinant Rat Icos protein, His-tagged E.coli His
    Rat Icos-8799R Recombinant Rat Icos, Fc tagged Human Cell His
    Rhesus ICOS-1015R Recombinant Rhesus ICOS Protein (Met1-Lys140), HlgG1 Fc-tagged HEK293 HlgG1 Fc
    Rhesus monkey ICOS-1661R Recombinant Rhesus Monkey ICOS Protein HEK293 N/A
    Rhesus monkey ICOS-1662R Recombinant Rhesus Monkey ICOS Protein, hIgG1-tagged HEK293 hIgG1
    Rhesus monkey ICOS-1663R Recombinant Rhesus Monkey ICOS Protein, hIgG4-tagged HEK293 hIgG4
    Rhesus Macaque ICOS-2187R Recombinant Rhesus monkey ICOS Protein, His-tagged Mammalian Cell His
    Chicken ICOS-3729C Recombinant Chicken ICOS Mammalian Cell His

    icos involved in several pathways and played different roles in them. We selected most pathways icos participated on our site, such as Cell adhesion molecules (CAMs), T cell receptor signaling pathway, Intestinal i, which may be useful for your reference. Also, other proteins which involved in the same pathway with icos were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cell adhesion molecules (CAMs) HLA-DRB5; ITGB2L; MHC1UEA; HLA-DPB1; ITGB1; CADM1; SDC4; CLDN22; CDH4; GLG1
    T cell receptor signaling pathway EVLB; CD3E; PIK3CG; MAP2K1; IL5; PAK6; CD28; LAT; MAPK13; NCK1
    Intestinal i CXCR4B; IL15RA; IL4; MHC2A; HLA-DRB5; Icosl; TNFSF13; IL15; IL6; H2-AA
    ne network for IgA production CD40LG; IL5; HLA-DRB5; HLA-DRB3; TNFRSF13B; HLA-DRA; CXCL12; Icosl; CXCR4; MHC2DAB
    Primary i Cd79a, Cd79b; CD19; IGLL1; AIRE; CD40; CD3E; DCLRE1C; BTK; CD40LG; IKBKG

    icos has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by icos itself. We selected most functions icos had, and list some proteins which have the same functions with icos. You can find most of the proteins on our site.

    Function Related Protein

    icos has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with icos here. Most of them are supplied by our site. Hope this information will be useful for your research of icos.


    Stone, EL; Pepper, M; et al. ICOS Coreceptor Signaling Inactivates the Transcription Factor FOXO1 to Promote Tfh Cell Differentiation. IMMUNITY 42:239-251(2015).
    Yu, J; He, SB; et al. Interleukin-21 promotes the development of ulcerative colitis and regulates the proliferation and secretion of follicular T helper cells in the colitides microenvironment. MOLECULAR MEDICINE REPORTS 11:1049-1056(2015).

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