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ICOS

Official Full Name

inducible T-cell co-stimulator
Overview

The protein encoded by this gene belongs to the CD28 and CTLA-4 cell-surface receptor family. It forms homodimers and plays an important role in cell-cell signaling, immune responses, and regulation of cell proliferation.
Synonyms

ICOS; inducible T-cell co-stimulator; inducible T-cell costimulator; activation inducible lymphocyte immunomediatory molecule; AILIM; CD278; inducible costimulator; activation-inducible lymphocyte immunomediatory molecule; CVID1; MGC39850;

Type

Recombinant Proteins
Cell & Tissue Lysates
GMP Proteins
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Mouse
Rat
Rhesus
Rhesus Macaque
Rhesus monkey

Source

CHO
E.coli
HEK293
Human Cell
Human Cells
Mammalian Cell
Mammalian cells
Sf21 Insect Cell

Tag

C
hFc
Avi
rFc
Fc
hIgG4
His
GST
mFc
Non

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	ICOS-3243H	Active Recombinant Human ICOS, Fc-His tagged	HEK293	His&Fc	Met 1-Phe 141	$498 / 50µg
Human	ICOS-1628H	Active Recombinant Human ICOS protein	Mammalian cells	Non		Inquiry
Human	ICOS-1532H	Active Recombinant Human ICOS, HIgG1 Fc-tagged, mutant	CHO	Fc	Glu21-Leu139	Inquiry
Human	ICOS-1533H	Active Recombinant Human ICOS, HIgG1 Fc-tagged	CHO	Fc	Glu21-Leu139	Inquiry
Human	ICOS-1531H	Active Recombinant Human ICOS, MIgG2a Fc-tagged	CHO	Fc	Glu21-Leu139	Inquiry
Human	ICOS-185H	Recombinant Human ICOS, Fc-tagged	CHO	Fc	21-139	Inquiry
Human	ICOS-3244H	Recombinant Human ICOS protein, Fc-tagged	HEK293	Fc	Glu21-Phe141	$798 / 100µg
Human	ICOS-175H	Recombinant Human ICOS Protein, Fc/His-tagged	HEK293	His&Fc	Glu21 – Lys140	Inquiry
Human	ICOS-390H	Recombinant Human ICOS protein	HEK293	Non	Met 1-Phe 141	$898 / 100µg
Human	ICOS-7659H	Recombinant Human ICOS protein, His & GST-tagged	E.coli	His&GST	Phe31~Lys190	Inquiry
Human	ICOS-2444HCL	Recombinant Human ICOS cell lysate	Human Cell	Non		Inquiry
Human	ICOS-3245H	Active Recombinant Human ICOS protein, rFc-tagged	HEK293	rFc	Met1-Phe141	$498 / 50µg
Human	ICOS-152H	Recombinant Human ICOS Protein, His-tagged	Human Cells	His		Inquiry
Human	ICOS-378H	Active Recombinant Human ICOS protein, His-tagged	HEK293	His	Glu21-Phe141	$798 / 100µg
Human	ICOS-390HAF488	Recombinant Human ICOS Protein, Gly/Pro-tagged, Alexa Fluor 488 conjugated	HEK293		Met1-Phe141	$798 / 20μg $1,298 / 50μg $1,998 / 100μg
Human	ICOS-4422H	Recombinant Human ICOS Protein, His (Fc)-Avi-tagged	HEK293	His&Fc&Avi		Inquiry
Human	ICOS-0233H	Active Recombinant Human ICOS protein, His-Avi-tagged, Biotinylated	HEK293	His&Avi	Glu21-Phe141	Inquiry
Human	ICOS-968H	Recombinant Human ICOS protein, His-Avi-tagged	HEK293	His&Avi	Glu21-Phe141	Inquiry
Human	ICOS-219H	Recombinant Human ICOS Protein (Glu21-Lys140), C-mFc and 6×His-tagged	HEK293	His&mFc	Glu21-Lys140	Inquiry
Human	ICOS-0232H	Active Recombinant Human ICOS protein, Fc-tagged	HEK293	Fc	Glu21-Phe141	Inquiry
Human	ICOS-3472H	Recombinant Human ICOS Protein (Glu21-Phe141), C-Fc tagged	Mammalian cells	Fc	Glu21-Phe141	Inquiry
Human	ICOS-101HG	Active GMP Recombinant Human ICOS protein, Fc-tagged	HEK293	Fc	DNA sequence encoding Human ICOS(NCBI Reference Sequence: NP_036224.1) was expressed with Fc tag at the C-terminal.	Inquiry
Human	ICOS-4422H-B	Recombinant Human ICOS Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Human	ICOS-0699H	Recombinant Human ICOS Protein (Met1-Lys140), C-Fc tagged	Mammalian cells	Fc	Met1-Lys140	Inquiry
Human	ICOS-390HAF555	Recombinant Human ICOS Protein, Gly/Pro-tagged, Alexa Fluor 555 conjugated	HEK293		Met1-Phe141	$798 / 20μg $1,298 / 50μg $1,998 / 100μg
Human	ICOS-0928H	Recombinant Human ICOS Protein (Glu21-Lys140), N-His tagged	E.coli	His	Glu21-Lys140	Inquiry
Human	ICOS-390HF	Recombinant Human ICOS Protein, Gly/Pro-tagged, FITC conjugated	HEK293		Met1-Phe141	$798 / 20μg $1,298 / 50μg $1,998 / 100μg
Human	ICOS-218H	Recombinant Human ICOS Protein (Glu21-Lys140), C-hFc-tagged	HEK293	Fc	Glu21-Lys140	Inquiry
Human	ICOS-055H	Recombinant Human ICOS Protein, His-tagged	E.coli	His		Inquiry
Human	ICOS-672H	Recombinant Human ICOS Protein, Fc-tagged	HEK293	Fc	199	Inquiry
Human	ICOS-390HAF647	Recombinant Human ICOS Protein, Gly/Pro-tagged, Alexa Fluor 647 conjugated	HEK293		Met1-Phe141	$798 / 20μg $1,298 / 50μg $1,998 / 100μg
Mouse	Icos-1821M	Active Recombinant Mouse Icos, MIgG2a Fc-tagged	CHO	Fc	Glu21-Leu142	Inquiry
Mouse	ICOS-1248M	Acitve Recombinant Mouse ICOS protein(Met1-Gln135), His-tagged	HEK293	His	Met1-Gln135	Inquiry
Mouse	Icos-6951M	Active Recombinant Mouse Icos protein(Met1-Leu142), hFc-tagged	HEK293	Fc	Met1-Leu142	$658 / 100µg
Mouse	Icos-1747M	Recombinant Mouse Inducible T-cell Co-stimulator	Sf21 Insect Cell	Non		Inquiry
Mouse	Icos-33M	Recombinant Mouse Icos protein, His-tagged	E.coli	His	Asn35-Ile131	Inquiry
Mouse	ICOS-1724MCL	Recombinant Mouse ICOS cell lysate	Human Cell	Non		Inquiry
Mouse	Icos-6951MAF488	Recombinant Mouse Icos Protein, Fc-tagged, Alexa Fluor 488 conjugated	HEK293	Fc	363	$798 / 20μg $1,298 / 50μg $1,998 / 100μg
Mouse	ICOS-2224M	Active Recombinant Mouse ICOS protein, hFc&Avi-tagged, Biotinylated	HEK293	Fc&Avi	Met1-Leu142	Inquiry
Mouse	ICOS-827M	Active Recombinant Mouse ICOS protein(Met1-Leu144), rFc-tagged	HEK293	C-rFc	Met1-Leu144	$461 / 20µg
Mouse	ICOS-729M	Recombinant Mouse ICOS protein (C137S, C138S), Fc-tagged	HEK293	Fc	Glu21-Leu144	$786 / 100µg
Mouse	ICOS-0231M	Active Recombinant Mouse ICOS protein, Fc-tagged	HEK293	Fc	Glu21-Leu144	Inquiry
Mouse	ICOS-2711M	Recombinant Mouse ICOS protein (C137S, C138S), His-tagged	HEK293	His	Glu21-Leu144	$786 / 100µg
Mouse	Icos-6951MF	Recombinant Mouse Icos Protein, Fc-tagged, FITC conjugated	HEK293	Fc	363	$798 / 20μg $1,298 / 50μg $1,998 / 100μg
Mouse	Icos-6951MAF555	Recombinant Mouse Icos Protein, Fc-tagged, Alexa Fluor 555 conjugated	HEK293	Fc	363	$798 / 20μg $1,298 / 50μg $1,998 / 100μg
Mouse	Icos-5926M	Recombinant Mouse Icos Protein (Glu21-Leu142), C-His tagged	Mammalian cells	His	Glu21-Leu142	Inquiry
Mouse	Icos-6951MAF647	Recombinant Mouse Icos Protein, Fc-tagged, Alexa Fluor 647 conjugated	HEK293	Fc	363	$798 / 20μg $1,298 / 50μg $1,998 / 100μg
Rat	ICOS-2981R	Recombinant Rat ICOS Protein	Mammalian Cell	His		Inquiry
Rat	Icos-8799R	Recombinant Rat Icos, Fc tagged	Human Cell	His	Met1-Leu142	$461 / 50µg
Rat	Icos-7660R	Recombinant Rat Icos protein, His-tagged	E.coli	His	Gln39~Glu133	Inquiry
Rat	ICOS-1195RCL	Recombinant Rat ICOS cell lysate	Human Cell	Non		Inquiry
Rat	ICOS-2636R-B	Recombinant Rat ICOS Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rat	Icos-8799RAF488	Recombinant Rat Icos Protein, Fc-tagged, Alexa Fluor 488 conjugated	HEK293	Fc	363	$798 / 20μg $1,298 / 50μg $1,998 / 100μg
Rat	Icos-8799RAF647	Recombinant Rat Icos Protein, Fc-tagged, Alexa Fluor 647 conjugated	HEK293	Fc	363	$798 / 20μg $1,298 / 50μg $1,998 / 100μg
Rat	Icos-4933R	Recombinant Rat Icos protein, His-tagged	E.coli	His	21-145aa	Inquiry
Rat	Icos-8799RF	Recombinant Rat Icos Protein, Fc-tagged, FITC conjugated	HEK293	Fc	363	$798 / 20μg $1,298 / 50μg $1,998 / 100μg
Rat	ICOS-2636R	Recombinant Rat ICOS Protein, His (Fc)-Avi-tagged	HEK293	His&Fc&Avi		Inquiry
Rat	Icos-8799RAF555	Recombinant Rat Icos Protein, Fc-tagged, Alexa Fluor 555 conjugated	HEK293	Fc	363	$798 / 20μg $1,298 / 50μg $1,998 / 100μg
Rat	ICOS-0230R	Recombinant Rat?ICOS?protein(Glu 21 - Pro 145 (C137S,C138S)), His-tagged	HEK293	His	Glu21-Pro145	Inquiry
Rat	ICOS-1283R	Recombinant Rat ICOS protein(Met1-Leu142), hFc-tagged	HEK293	Fc	Met1-Leu142	Inquiry
Rhesus monkey	ICOS-1663R	Recombinant Rhesus Monkey ICOS Protein, hIgG4-tagged	HEK293	hIgG4	20-140	Inquiry
Rhesus monkey	ICOS-1661R	Recombinant Rhesus Monkey ICOS Protein	HEK293	Non	20-140	Inquiry
Rhesus monkey	ICOS-1662R	Recombinant Rhesus Monkey ICOS Protein, hIgG1-tagged	HEK293	Fc	20-140	Inquiry
Rhesus	ICOS-1015R	Active Recombinant Rhesus ICOS protein, hFc-tagged	HEK293	Fc	Met1-Lys140	Inquiry
Rhesus	ICOS-1611R	Recombinant Rhesus ICOS protein(Met1-Lys140), hFc&Avi-tagged, Biotinylated	HEK293	C-hFc&Avi	Met1-Lys140	Inquiry
Rhesus Macaque	ICOS-2187R	Recombinant Rhesus monkey ICOS Protein, His-tagged	Mammalian Cell	His		Inquiry
Rhesus Macaque	ICOS-2008R-B	Recombinant Rhesus Macaque ICOS Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rhesus Macaque	ICOS-2008R	Recombinant Rhesus Macaque ICOS Protein, His (Fc)-Avi-tagged	HEK293	His&Fc&Avi		Inquiry
Chicken	ICOS-3729C	Recombinant Chicken ICOS	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
Other Resource

ICOS involved in several pathways and played different roles in them. We selected most pathways ICOS participated on our site, such as Cell adhesion molecules (CAMs), T cell receptor signaling pathway, Intestinal i, which may be useful for your reference. Also, other proteins which involved in the same pathway with ICOS were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Cell adhesion molecules (CAMs)	CLDN15LB;GLG1;BMA1;HLA-DOB;HLA-DOA;SELPLG;LRRC4C;CLDN19;MHC2A
T cell receptor signaling pathway	ICOS;GSK3B;DEF6A;PTPN6;PAK6;PPP3CC;FYN;CBLB;DBNLB
Intestinal i	IL6;PIGR;BLB2;HLA-DRB1;HLA-DRB5;CCL28;IL-15RA;CD40;CXCR4A
ne network for IgA production	HLA-DQA1;MHC2A;ICOSLG;H2-AA;MHC2DCB;BMA1;HLA-DMB;CXCL12;HLA-DRA
Primary i	CD8A;ICOS;IGLL1;UNG;RAG2;BTK;RFX5;CD40;AICDA
nodeficiency	DCLRE1C;CD79A;CD3D;RAG1;CD19;ZAP70;CD8B;Cd79a, Cd79b;CD40

ICOS has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by ICOS itself. We selected most functions ICOS had, and list some proteins which have the same functions with ICOS. You can find most of the proteins on our site.

Function	Related Protein

ICOS has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ICOS here. Most of them are supplied by our site. Hope this information will be useful for your research of ICOS.

WIF1

Gene Family

Research Area

Cancer Drug Targets

Immune Checkpoints

B7/CD28 Family

Gamma Delta T Cells

T Follicular Helper (Tfh) Cells

Natural Killer T (NKT) Cells

Co-stimulatory Molecules

Inflammatory Bowel Diseases Therapeutic Targets

Stone, EL; Pepper, M; et al. ICOS Coreceptor Signaling Inactivates the Transcription Factor FOXO1 to Promote Tfh Cell Differentiation. IMMUNITY 42:239-251(2015).

Yu, J; He, SB; et al. Interleukin-21 promotes the development of ulcerative colitis and regulates the proliferation and secretion of follicular T helper cells in the colitides microenvironment. MOLECULAR MEDICINE REPORTS 11:1049-1056(2015).