ICOS

  • Official Full Name

    inducible T-cell co-stimulator

  • Overview

    The protein encoded by this gene belongs to the CD28 and CTLA-4 cell-surface receptor family. It forms homodimers and plays an important role in cell-cell signaling, immune responses, and regulation of cell proliferation.
  • Synonyms

    ICOS; inducible T-cell co-stimulator; inducible T-cell costimulator; activation inducible lymphocyte immunomediatory molecule; AILIM; CD278; inducible costimulator; activation-inducible lymphocyte immunomediatory molecule; CVID1; MGC39850;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • GMP Proteins
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Rhesus
  • Rhesus Macaque
  • Rhesus monkey
  • CHO
  • E.coli
  • HEK293
  • Human Cell
  • Human Cells
  • Mammalian Cell
  • Mammalian cells
  • Sf21 Insect Cell
  • C
  • Fc
  • hFc
  • His
  • mFc
  • 6×His
  • rFc
  • FC
  • Fc|His
  • Gly
  • Pro
  • Avi
  • hIgG1
  • hIgG4
  • His (Fc)
  • His|GST
  • human|IgG1|Fc
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ICOS-3243H Active Recombinant Human ICOS, Fc-His tagged HEK293 FC/His
Human ICOS-1628H Active Recombinant Human ICOS protein Mammalian cells N/A
Human ICOS-1532H Active Recombinant Human ICOS, HIgG1 Fc-tagged, mutant CHO Fc
Human ICOS-1533H Active Recombinant Human ICOS, HIgG1 Fc-tagged CHO Fc
Human ICOS-1531H Active Recombinant Human ICOS, MIgG2a Fc-tagged CHO Fc
Human ICOS-185H Recombinant Human ICOS, Fc-tagged CHO Fc
Human ICOS-3244H Recombinant Human ICOS protein, Fc-tagged HEK293 human/IgG1/Fc
Human ICOS-175H Recombinant Human ICOS Protein, Fc/His-tagged HEK293 Fc/His
Human ICOS-390H Recombinant Human ICOS protein HEK293 N/A
Human ICOS-7659H Recombinant Human ICOS protein, His & GST-tagged E.coli His/GST
Human ICOS-2444HCL Recombinant Human ICOS cell lysate Human Cell N/A
Human ICOS-3245H Active Recombinant Human ICOS protein, rFc-tagged HEK293 rFc
Human ICOS-152H Recombinant Human ICOS Protein, His-tagged Human Cells His
Human ICOS-378H Active Recombinant Human ICOS protein, His-tagged HEK293 His
Human ICOS-390HAF488 Recombinant Human ICOS Protein, Gly/Pro-tagged, Alexa Fluor 488 conjugated HEK293 Gly/Pro
Human ICOS-4422H Recombinant Human ICOS Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human ICOS-0233H Active Recombinant Human ICOS protein, His-Avi-tagged, Biotinylated HEK293 His-Avi
Human ICOS-968H Recombinant Human ICOS protein, His-Avi-tagged HEK293 His-Avi
Human ICOS-219H Recombinant Human ICOS Protein (Glu21-Lys140), C-mFc and 6×His-tagged HEK293 C-mFc and 6×His
Human ICOS-0232H Active Recombinant Human ICOS protein, Fc-tagged HEK293 Fc
Human ICOS-3472H Recombinant Human ICOS Protein (Glu21-Phe141), C-Fc tagged Mammalian cells C-Fc
Human ICOS-101HG Active GMP Recombinant Human ICOS protein, Fc-tagged HEK293 Fc
Human ICOS-4422H-B Recombinant Human ICOS Protein Pre-coupled Magnetic Beads HEK293
Human ICOS-0699H Recombinant Human ICOS Protein (Met1-Lys140), C-Fc tagged Mammalian cells C-Fc
Human ICOS-390HAF555 Recombinant Human ICOS Protein, Gly/Pro-tagged, Alexa Fluor 555 conjugated HEK293 Gly/Pro
Human ICOS-0928H Recombinant Human ICOS Protein (Glu21-Lys140), N-His tagged E.coli N-His
Human ICOS-390HF Recombinant Human ICOS Protein, Gly/Pro-tagged, FITC conjugated HEK293 Gly/Pro
Human ICOS-218H Recombinant Human ICOS Protein (Glu21-Lys140), C-hFc-tagged HEK293 C-hFc
Human ICOS-055H Recombinant Human ICOS Protein, His-tagged E.coli His
Human ICOS-672H Recombinant Human ICOS Protein, Fc-tagged HEK293 Fc
Human ICOS-390HAF647 Recombinant Human ICOS Protein, Gly/Pro-tagged, Alexa Fluor 647 conjugated HEK293 Gly/Pro
Mouse Icos-1821M Active Recombinant Mouse Icos, MIgG2a Fc-tagged CHO Fc
Mouse ICOS-1248M Acitve Recombinant Mouse ICOS protein(Met1-Gln135), His-tagged HEK293 C-His
Mouse Icos-6951M Active Recombinant Mouse Icos protein(Met1-Leu142), hFc-tagged HEK293 C-hFc
Mouse Icos-1747M Recombinant Mouse Inducible T-cell Co-stimulator Sf21 Insect Cell N/A
Mouse Icos-33M Recombinant Mouse Icos protein, His-tagged E.coli His
Mouse ICOS-1724MCL Recombinant Mouse ICOS cell lysate Human Cell N/A
Mouse Icos-6951MAF488 Recombinant Mouse Icos Protein, Fc-tagged, Alexa Fluor 488 conjugated HEK293 Fc
Mouse ICOS-2224M Active Recombinant Mouse ICOS protein, hFc&Avi-tagged, Biotinylated HEK293 hFc&Avi
Mouse ICOS-827M Active Recombinant Mouse ICOS protein(Met1-Leu144), rFc-tagged HEK293 C-rFc
Mouse ICOS-729M Recombinant Mouse ICOS protein (C137S, C138S), Fc-tagged HEK293 human/IgG1/Fc
Mouse ICOS-0231M Active Recombinant Mouse ICOS protein, Fc-tagged HEK293 Fc
Mouse ICOS-2711M Recombinant Mouse ICOS protein (C137S, C138S), His-tagged HEK293 His
Mouse Icos-6951MF Recombinant Mouse Icos Protein, Fc-tagged, FITC conjugated HEK293 Fc
Mouse Icos-6951MAF555 Recombinant Mouse Icos Protein, Fc-tagged, Alexa Fluor 555 conjugated HEK293 Fc
Mouse Icos-5926M Recombinant Mouse Icos Protein (Glu21-Leu142), C-His tagged Mammalian cells C-His
Mouse Icos-6951MAF647 Recombinant Mouse Icos Protein, Fc-tagged, Alexa Fluor 647 conjugated HEK293 Fc
Rat ICOS-2981R Recombinant Rat ICOS Protein Mammalian Cell His
Rat Icos-8799R Recombinant Rat Icos, Fc tagged Human Cell His
Rat Icos-7660R Recombinant Rat Icos protein, His-tagged E.coli His
Rat ICOS-1195RCL Recombinant Rat ICOS cell lysate Human Cell N/A
Rat ICOS-2636R-B Recombinant Rat ICOS Protein Pre-coupled Magnetic Beads HEK293
Rat Icos-8799RAF488 Recombinant Rat Icos Protein, Fc-tagged, Alexa Fluor 488 conjugated HEK293 Fc
Rat Icos-8799RAF647 Recombinant Rat Icos Protein, Fc-tagged, Alexa Fluor 647 conjugated HEK293 Fc
Rat Icos-4933R Recombinant Rat Icos protein, His-tagged E.coli His
Rat Icos-8799RF Recombinant Rat Icos Protein, Fc-tagged, FITC conjugated HEK293 Fc
Rat ICOS-2636R Recombinant Rat ICOS Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat Icos-8799RAF555 Recombinant Rat Icos Protein, Fc-tagged, Alexa Fluor 555 conjugated HEK293 Fc
Rat ICOS-0230R Active Recombinant Rat ICOS protein, His-tagged HEK293 His
Rat ICOS-1283R Recombinant Rat ICOS protein(Met1-Leu142), hFc-tagged HEK293 C-hFc
Rhesus monkey ICOS-1663R Recombinant Rhesus Monkey ICOS Protein, hIgG4-tagged HEK293 hIgG4
Rhesus monkey ICOS-1661R Recombinant Rhesus Monkey ICOS Protein HEK293 N/A
Rhesus monkey ICOS-1662R Recombinant Rhesus Monkey ICOS Protein, hIgG1-tagged HEK293 hIgG1
Rhesus ICOS-1611R Recombinant Rhesus ICOS protein, hFc&Avi-tagged, Biotinylated HEK293 hFc&Avi
Rhesus ICOS-1015R Active Recombinant Rhesus ICOS protein, hFc-tagged HEK293 hFc
Rhesus Macaque ICOS-2187R Recombinant Rhesus monkey ICOS Protein, His-tagged Mammalian Cell His
Rhesus Macaque ICOS-2008R-B Recombinant Rhesus Macaque ICOS Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque ICOS-2008R Recombinant Rhesus Macaque ICOS Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Chicken ICOS-3729C Recombinant Chicken ICOS Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • ICOS Related Articles
  • ICOS Related Gene Family
  • ICOS Related Research Area

ICOS involved in several pathways and played different roles in them. We selected most pathways ICOS participated on our site, such as Cell adhesion molecules (CAMs), T cell receptor signaling pathway, Intestinal i, which may be useful for your reference. Also, other proteins which involved in the same pathway with ICOS were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cell adhesion molecules (CAMs)NLGN3A;CDH5;NTNG1;PVRL1B;MHC1UEA;HLA-DRB3;CNTNAP2;NCAM1;CLDN5B
T cell receptor signaling pathwayCD28;PDPK1;VAV3;CD8A;NFKBIA;NFKBIE;PIK3R1;MUC1;PPP3CB
Intestinal iMHC2A;TNFRSF13B;TNFSF13;IL5;CD86;IL15;Il2;HLA-DRB4;HLA-DMB
ne network for IgA productionTNFRSF17;HLA-DPA1;LTBR;TGFB1A;MADCAM1;HLA-DMA;HLA-DQB1;HLA-DOB;HLA-DMB
Primary iBLNK;RFXAP;CD40;CD8B;CD4;LCK;RFXANK;PTPRC;CD8A
nodeficiencyPTPRC;IGLL1;AICDA;CD3D;UNG;TNFRSF13B;CD40LG;CD8B1;RAG2

ICOS has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by ICOS itself. We selected most functions ICOS had, and list some proteins which have the same functions with ICOS. You can find most of the proteins on our site.

Function Related Protein

ICOS has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ICOS here. Most of them are supplied by our site. Hope this information will be useful for your research of ICOS.

WIF1

Stone, EL; Pepper, M; et al. ICOS Coreceptor Signaling Inactivates the Transcription Factor FOXO1 to Promote Tfh Cell Differentiation. IMMUNITY 42:239-251(2015).
Yu, J; He, SB; et al. Interleukin-21 promotes the development of ulcerative colitis and regulates the proliferation and secretion of follicular T helper cells in the colitides microenvironment. MOLECULAR MEDICINE REPORTS 11:1049-1056(2015).
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