The protein encoded by this gene belongs to the CD28 and CTLA-4 cell-surface receptor family. It forms homodimers and plays an important role in cell-cell signaling, immune responses, and regulation of cell proliferation.
ICOS involved in several pathways and played different roles in them. We selected most pathways ICOS participated on our site, such as Cell adhesion molecules (CAMs), T cell receptor signaling pathway, Intestinal i, which may be useful for your reference. Also, other proteins which involved in the same pathway with ICOS were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
ICOS has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by ICOS itself. We selected most functions ICOS had, and list some proteins which have the same functions with ICOS. You can find most of the proteins on our site.
ICOS has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ICOS here. Most of them are supplied by our site. Hope this information will be useful for your research of ICOS.
Stone, EL; Pepper, M; et al. ICOS Coreceptor Signaling Inactivates the Transcription Factor FOXO1 to Promote Tfh Cell Differentiation. IMMUNITY 42:239-251(2015).
Yu, J; He, SB; et al. Interleukin-21 promotes the development of ulcerative colitis and regulates the proliferation and secretion of follicular T helper cells in the colitides microenvironment. MOLECULAR MEDICINE REPORTS 11:1049-1056(2015).