ICOS

  • Official Full Name

    inducible T-cell co-stimulator

  • Overview

    The protein encoded by this gene belongs to the CD28 and CTLA-4 cell-surface receptor family. It forms homodimers and plays an important role in cell-cell signaling, immune responses, and regulation of cell proliferation.

  • Synonyms

    ICOS;inducible T-cell co-stimulator;inducible T-cell costimulator;activation inducible lymphocyte immunomediatory molecule;AILIM;CD278;inducible costimulator;activation-inducible lymphocyte immunomediatory molecule;CVID1;MGC39850

Recombinant Proteins

  • Human
  • Mouse
  • Rat
  • Rhesus macaque
  • Chicken
  • HEK293
  • Human Cells
  • CHO
  • Mammalian Cells
  • Sf21 Cells
  • E.coli
  • Insect Cells
  • Fc
  • His
  • Non
  • rFc
  • hIgG4
  • GST
  • Avi
  • mFc
Cat.# Product name Source (Host) Species Tag Protein Length Price
ICOS-3243H Active Recombinant Human ICOS, Fc-His tagged HEK293 Human Fc&His Met 1-Phe 141
ICOS-3244H Recombinant Human ICOS protein, hFc-tagged HEK293 Human Fc Glu21-Phe141
ICOS-390H Recombinant Human ICOS protein HEK293 Human Non Met 1-Phe 141
Icos-6951M Active Recombinant Mouse Icos protein(Met1-Leu142), hFc-tagged HEK293 Mouse Fc Met1-Leu142
Icos-8799R Recombinant Rat Icos, Fc tagged Human Cells Rat His 1-142 a.a.
ICOS-1283R Recombinant Rat ICOS protein(Met1-Leu142), hFc-tagged HEK293 Rat Fc Met1-Leu142
ICOS-2711M Recombinant Mouse ICOS protein (C137S, C138S), His-tagged HEK293 Mouse His Glu21-Leu144
ICOS-3245H Active Recombinant Human ICOS protein, rFc-tagged HEK293 Human rFc Met1-Phe141
ICOS-378H Recombinant Human ICOS protein, His-tagged HEK293 Human His Glu21-Gln134
ICOS-390HAF488 Recombinant Human ICOS Protein, Gly/Pro-tagged, Alexa Fluor 488 conjugated HEK293 Human Met1-Phe141
ICOS-390HAF555 Recombinant Human ICOS Protein, Gly/Pro-tagged, Alexa Fluor 555 conjugated HEK293 Human Met1-Phe141
ICOS-390HAF647 Recombinant Human ICOS Protein, Gly/Pro-tagged, Alexa Fluor 647 conjugated HEK293 Human Met1-Phe141
ICOS-390HF Recombinant Human ICOS Protein, Gly/Pro-tagged, FITC conjugated HEK293 Human Met1-Phe141
Icos-6951MAF488 Recombinant Mouse Icos Protein, Fc-tagged, Alexa Fluor 488 conjugated HEK293 Mouse Fc 363
Icos-6951MAF555 Recombinant Mouse Icos Protein, Fc-tagged, Alexa Fluor 555 conjugated HEK293 Mouse Fc 363
Icos-6951MAF647 Recombinant Mouse Icos Protein, Fc-tagged, Alexa Fluor 647 conjugated HEK293 Mouse Fc 363
Icos-6951MF Recombinant Mouse Icos Protein, Fc-tagged, FITC conjugated HEK293 Mouse Fc 363
ICOS-729M Recombinant Mouse ICOS protein (C137S, C138S), Fc-tagged HEK293 Mouse Fc Glu21-Leu144
ICOS-827M Active Recombinant Mouse ICOS protein(Met1-Leu144), rFc-tagged HEK293 Mouse rFc Met1-Leu144
Icos-8799RAF488 Recombinant Rat Icos Protein, Fc-tagged, Alexa Fluor 488 conjugated HEK293 Rat Fc 363
Icos-8799RAF555 Recombinant Rat Icos Protein, Fc-tagged, Alexa Fluor 555 conjugated HEK293 Rat Fc 363
Icos-8799RAF647 Recombinant Rat Icos Protein, Fc-tagged, Alexa Fluor 647 conjugated HEK293 Rat Fc 363
Icos-8799RF Recombinant Rat Icos Protein, Fc-tagged, FITC conjugated HEK293 Rat Fc 363
ICOS-1531H Active Recombinant Human ICOS, MIgG2a Fc-tagged CHO Human Fc 21-139 a.a.
ICOS-1532H Active Recombinant Human ICOS, HIgG1 Fc-tagged, mutant CHO Human Fc 21-139 a.a.
ICOS-1533H Active Recombinant Human ICOS, HIgG1 Fc-tagged CHO Human Fc 21-139 a.a.
ICOS-1628H Active Recombinant Human ICOS protein Mammalian Cells Human Non
Icos-1821M Active Recombinant Mouse Icos, MIgG2a Fc-tagged CHO Mouse Fc 21-142 a.a.
ICOS-1015R Active Recombinant Rhesus ICOS protein, hFc-tagged HEK293 Rhesus macaque Fc 1-140 a.a.
ICOS-1248M Acitve Recombinant Mouse ICOS protein(Met1-Gln135), His-tagged HEK293 Mouse His Met1-Gln135
ICOS-6754H Recombinant Human ICOS protein, His-tagged HEK293 Human His Glu21-Phe141(C136S,C137S)
ICOS-1661R Recombinant Rhesus Monkey ICOS Protein HEK293 Rhesus macaque Non 20-140 a.a.
ICOS-1662R Recombinant Rhesus Monkey ICOS Protein, hIgG1-tagged HEK293 Rhesus macaque Fc 20-140 a.a.
ICOS-1663R Recombinant Rhesus Monkey ICOS Protein, hIgG4-tagged HEK293 Rhesus macaque hIgG4 20-140 a.a.
Icos-1747M Recombinant Mouse Inducible T-cell Co-stimulator Sf21 Cells Mouse Non
ICOS-175H Recombinant Human ICOS Protein, Fc/His-tagged HEK293 Human Fc&His Glu21 – Lys140
ICOS-185H Recombinant Human ICOS, Fc-tagged CHO Human Fc 21-139 a.a.
ICOS-2187R Recombinant Rhesus monkey ICOS Protein, His-tagged Mammalian Cells Rhesus macaque His
ICOS-2981R Recombinant Rat ICOS Protein Mammalian Cells Rat His
Icos-33M Recombinant Mouse Icos protein, His-tagged E.coli Mouse His 35-131 a.a.
ICOS-3729C Recombinant Chicken ICOS Mammalian Cells Chicken His
ICOS-7659H Recombinant Human ICOS protein, His & GST-tagged E.coli Human GST&His Phe31~Lys190
Icos-7660R Recombinant Rat Icos protein, His-tagged E.coli Rat His Gln39~Glu133
ICOS-1195RCL Recombinant Rat ICOS cell lysate Human Cells Rat Non
ICOS-1724MCL Recombinant Mouse ICOS cell lysate Human Cells Mouse Non
ICOS-2444HCL Recombinant Human ICOS cell lysate Human Cells Human Non
ICOS-0230R Recombinant Rat ICOS protein(Glu 21 - Pro 145 (C137S HEK293 Rat His 21-145 a.a.
ICOS-0231M Recombinant Mouse ICOS protein, hFc-tagged HEK293 Mouse Fc Glu21-Leu144
ICOS-0232H Active Recombinant Human ICOS protein, Fc-tagged HEK293 Human Fc 21-141 a.a.
ICOS-0233H Active Recombinant Human ICOS protein, His-Avi-tagged, Biotinylated HEK293 Human Avi&His 21-141 a.a.
ICOS-055H Recombinant Human ICOS Protein, His-tagged E.coli Human His
ICOS-0699H Recombinant Human ICOS Protein (Met1-Lys140), C-Fc tagged Mammalian Cells Human Fc Met1-Lys140
ICOS-0928H Recombinant Human ICOS Protein (Glu21-Lys140), N-His tagged E.coli Human His Glu21-Lys140
ICOS-101HG Active GMP Recombinant Human ICOS protein, Fc-tagged HEK293 Human Fc DNA sequence encoding Human ICOS(NCBI Reference Sequence: NP_036224.1) was expressed with Fc tag at the C-terminal.
ICOS-152H Recombinant Human ICOS Protein, His-tagged Human Cells Human His
ICOS-1611R Recombinant Rhesus ICOS protein(Met1-Lys140), hFc&Avi-tagged, Biotinylated HEK293 Rhesus macaque Avi&Fc Met1-Lys140
ICOS-2008R Recombinant Rhesus Macaque ICOS Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque Avi&Fc&His
ICOS-2008R-B Recombinant Rhesus Macaque ICOS Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque
ICOS-218H Recombinant Human ICOS Protein (Glu21-Lys140), C-hFc-tagged HEK293 Human Fc Glu21-Lys140
ICOS-219H Recombinant Human ICOS Protein (Glu21-Lys140), C-mFc and 6×His-tagged HEK293 Human His&mFc Glu21-Lys140
ICOS-2224M Active Recombinant Mouse ICOS protein, hFc&Avi-tagged, Biotinylated HEK293 Mouse Avi&Fc Met1-Leu142
ICOS-22H Active Recombinant Human ICOS Protein, His tagged CHO Human His
ICOS-2636R Recombinant Rat ICOS Protein, His (Fc)-Avi-tagged HEK293 Rat Avi&Fc&His
ICOS-2636R-B Recombinant Rat ICOS Protein Pre-coupled Magnetic Beads HEK293 Rat
ICOS-3472H Recombinant Human ICOS Protein (Glu21-Phe141), C-Fc tagged Mammalian Cells Human Fc Glu21-Phe141
ICOS-4422H Recombinant Human ICOS Protein, His (Fc)-Avi-tagged HEK293 Human Avi&Fc&His
ICOS-4422H-B Recombinant Human ICOS Protein Pre-coupled Magnetic Beads HEK293 Human
ICOS-44H Recombinant Human ICOS Protein, His&Fc tagged Insect Cells Human Fc&His
Icos-4933R Recombinant Rat Icos protein, His-tagged E.coli Rat His 21-145aa
Icos-5926M Recombinant Mouse Icos Protein (Glu21-Leu142), C-His tagged Mammalian Cells Mouse His Glu21-Leu142
ICOS-672H Recombinant Human ICOS Protein, Fc-tagged HEK293 Human Fc 199
ICOS-968H Recombinant Human ICOS protein, His-Avi-tagged HEK293 Human Avi&His Glu21-Phe141

    Involved Pathway

    ICOS involved in several pathways and played different roles in them. We selected most pathways ICOS participated on our site, such as Cell adhesion molecules (CAMs),T cell receptor signaling pathway,Intestinal i, which may be useful for your reference. Also, other proteins which involved in the same pathway with ICOS were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    ne network for IgA production CCL25B,TGFB1A,MHC2DEB,Icosl,Il2,MADCAM1,MHC2DAB,IL15RA,ITGB7,HLA-DRB5
    Primary i RFXAP,AIRE,ZAP70,CD40,BLNK,TAP2,UNG,IL7R,CD79A, Cd79b
    T cell receptor signaling pathway PIK3CD,GSK3B,OXSR1A,PIK3R5,MAPK12,PPP3R1,NFKBIA,IKBKB,MAP2K2,MAP2K1
    Intestinal i CCL27B,CXCR4,TGFB1A,HLA-DQA1,HLA-DMA,CD80,LTBR,TNFSF13,BLA,MHC2DAB
    Cell adhesion molecules (CAMs) CD99,NLGN2,CD40LG,ITGB1B.2,NCAM1,CLDN17,ITGA4,CLDNE,HLA-DRB3,CD80
    nodeficiency LCK,DCLRE1C,IGLL1,AICDA,Cd79a,IKBKG,AIRE,TNFRSF13B,CD8A,RFX5

    Protein Function

    ICOS has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by ICOS itself. We selected most functions ICOS had, and list some proteins which have the same functions with ICOS. You can find most of the proteins on our site.

    Function Related Protein

    Interacting Protein

    ICOS has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ICOS here. Most of them are supplied by our site. Hope this information will be useful for your research of ICOS.

    WIF1

    Resources

    Gene Families

    What is immunoglobulin superfamily (IgSF)

    Research Area

    Cancer Drug Targets
    B7/CD28 Family
    gamma delta T Cells
    Natural Killer T (NKT) Cells
    Inflammatory Bowel Diseases Therapeutic Targets
    Co-stimulatory Molecules
    T Follicular Helper (Tfh) Cells
    Immune Checkpoints

    References

    • Stone, EL; Pepper, M; et al. ICOS Coreceptor Signaling Inactivates the Transcription Factor FOXO1 to Promote Tfh Cell Differentiation. IMMUNITY 42:239-251(2015).
    • Yu, J; He, SB; et al. Interleukin-21 promotes the development of ulcerative colitis and regulates the proliferation and secretion of follicular T helper cells in the colitides microenvironment. MOLECULAR MEDICINE REPORTS 11:1049-1056(2015).

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