Active Recombinant Human PPARG, His-tagged
Cat.No. : | PPARG-67H |
Product Overview : | Peroxisome Proliferator Activated Receptor Gamma Human Recombinant is expressed in E.coli having a molecular weight of 59.2 kDa and fused to an amino terminal hexahistidine tag. |
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Description : | This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma. The protein encoded by this gene is PPAR-gamma and is a regulator of adipocyte differentiation. Additionally, PPAR-gamma has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer. Alternatively spliced transcript variants that encode different isoforms have been described. |
Source : | E. Coli |
Species : | Human |
Tag : | His |
Form : | Sterile Filtered clear solution. The protein solution contains PBS, 50% glycerol and 0.01% azide. |
Bio-activity : | Specific activity is 3-4 units/ml obtained by measuring the increase of NADPH in absorbance at 340 nm resulting from the reduction of NADP. In the coupled mode, one unit will produce 1.0 umole of NADPH per minute as glucose is phosphorylated by ATP at pH 7.4 at 300C. |
Molecular Mass : | 59.2 kDa |
AA Sequence : | MGSSHHHHHH SSGLVPRGSH MIASHLLAYF FTELNHDQVQ KVDQYLYHMR LSDETLLEIS KRFRKEMEKG LGATTHPTAA VKMLPTFVRS TPDGTEHGEF LALDLGGTNF RVLWVKVTDN GLQKVEMENQ IYAIPEDIMR GSGTQLFDHI AECLANFMDK LQIKDKKLPL GFTFSFPCHQTKLDESFLVS WTKGFKSSGV EGRDVVALIR KAIQRRGDFD IDIVAVVNDT VGTMMTCGYD DHNCEIGLIV GTGSNACYME EMRHIDMVEG DEGRMCINME WGAFGDDGSL NDIRTEFDQE IDMGSLNPGK QLFEKMISGM YMGELVRLIL VKMAKEELLF GGKLSPELLN TGRFETKDISDIEGEKDGIR KAREVLMRLG LDPTQEDCVA THRICQIVST RSASLCAATL AAVLQRIKENKGEERLRSTI GVDGSVYKKH PHFAKRLHKT VRRLVPGCDV RFLRSEDGSG KGAAMVTAVAYRLADQHRAR QKTLEHLQLS HDQLLEVKRR MKVEMERGLS KETHASAPVK MLPTYVCATPDGTEKGDFLA LDLGGTNFRV LLVRVRNGKW GGVEMHNKIY AIPQEVMHGT GDELFDHIVQ CIADFLEYMG MKGVSLPLGF TFSFPCQQNS LDESILLKWT KGFKASGCEG EDVVTLLKEA IHRREEFDLD VVAVVNDTVG TMMTCGFEDP HCEVGLIVGT GSNACYMEEM RNVELVEGEE GRMCVNMEWG AFGDNGCLDD FRTEFDVAVD ELSLNPGKQR FEKMISGMYL GEIVRNILID FTKRGLLFRG RISERLKTRG IFETKFLSQI ESDCLALLQV RAILQHLGLE STCDDSIIVK EVCTVVARRA AQLCGAGMAA VVDRIRENRG LDALKVTVGV DGTLYKLHPH FAKVMHETVK DLAPKCDVSF LQSEDGSGKG AALITAVACR IREAGQR. |
Purity : | Greater than 90.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE. |
Usage : | The products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals. |
Stability : | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. Avoid multiple freeze-thaw cycles. |
Storage Buffer : | 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. |
Gene Name : | PPARG peroxisome proliferator-activated receptor gamma [Homo sapiens (human) ] |
Official Symbol : | PPARG |
Synonyms : | PPARG; GLM1; CIMT1; NR1C3; PPARG1; PPARG2; PPARgamma; peroxisome proliferator-activated receptor gamma; PPAR gamma; PPAR-gamma; nuclear receptor subfamily 1 group C member 3; peroxisome proliferator-activated receptor gamma 1; peroxisome proliferator-activated nuclear receptor gamma variant 1 |
Gene ID : | 5468 |
mRNA Refseq : | NM_005037 |
Protein Refseq : | NP_005028 |
MIM : | 601487 |
UniProt ID : | P37231 |
Chromosome Location : | 3p25 |
Pathway : | Adipogenesis; Calcineurin-regulated NFAT-dependent transcription in lymphocytes; Developmental Biology |
Function : | DNA binding; RNA polymerase II regulatory region DNA binding; activating transcription factor binding |
Products Types
◆ Recombinant Protein | ||
PPARG-2602H | Recombinant Human PPARG Protein, MYC/DDK-tagged | +Inquiry |
PPARG-1741H | Recombinant Human PPARG Protein, His (Fc)-Avi-tagged | +Inquiry |
Pparg-1961M | Recombinant Mouse Pparg Protein, His-tagged | +Inquiry |
Pparg-5030M | Recombinant Mouse Pparg Protein, Myc/DDK-tagged | +Inquiry |
PPARG-547C | Recombinant Cynomolgus Monkey PPARG Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
PPARG-492HCL | Recombinant Human PPARG cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (7)
Ask a questionPPARG has two isoforms, PPARG1 (57 kDa) and PPARG2, a splice variant with an additional 30 amino acids at the N-terminus.
PPARG has two isoforms with molecular weights of 57 kDa and 54 kDa. Modified PPARG is about 67 kDa.
PPARG stands for Peroxisome Proliferator-Activated Receptor Gamma.
Yes, experimental data suggests a 45 kDa protein immunologically related to PPARG, called mt-PPAR, is located in mitochondria. Its molecular weight is less than PPARG2.
PPARG is a ligand-activated transcription factor that plays a crucial role in regulating lipid homeostasis, adipogenesis, insulin resistance, and organ development.
Defects in PPARG are associated with familial partial lipodystrophy type 3 (FPLD3), susceptibility to obesity, type 2 insulin-resistant diabetes, hypertension, and colon cancer.
PPARG is mainly localized in the nucleus, although it can also be detected in the cytoplasm, exhibiting extra-nuclear/non-genomic actions in certain contexts.
Customer Reviews (3)
Write a reviewIt was reassuring to use a product that adhered to green chemistry principles, reducing our impact on the environment.
The company's dedication to environmental sustainability reflected positively on the product and our research initiatives.
We appreciated the option to request modifications or custom formulations to meet our project's requirements.
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