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Official Full Name peroxisome proliferator-activated receptor gamma
Background This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma. The protein encoded by this gene is PPAR-gamma and is a regulator of adipocyte differentiation. Additionally, PPAR-gamma has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Jul 2008]
Synonyms PPARG; peroxisome proliferator-activated receptor gamma; GLM1; CIMT1; NR1C3; PPARG1; PPARG2; PPARgamma; PPAR gamma; PPAR-gamma; nuclear receptor subfamily 1 group C member 3; peroxisome proliferator-activated receptor gamma 1; peroxisome proliferator-activated nuclear receptor gamma variant 1;
    • Species :
    • Cattle
    • Chicken
    • Cynomolgus Monkey
    • Human
    • Mouse
    • Rabbit
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E. coli
    • E.coli
    • HEK293
    • HEK293T
    • Insect Cell
    • Mammalian Cell
    • Tag :
    • GST
    • His
    • MBP
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human PPARG-1090H Recombinant Human PPARG, Ligand Binding Domain, His-tagged E.coli His
    Human PPARG-1091H Recombinant Human PPARG, Ligand Binding Domain, GST-tagged E.coli GST
    Human PPARG-1872H Recombinant Human PPARG, GST-tagged E.coli GST
    Human PPARG-2602H Recombinant Human PPARG Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human PPARG-2772H Recombinant Human PPARG, 209-477 aa, His-tagged E.coli His
    Human PPARG-28670TH Recombinant Human PPARG E.coli N/A
    Human PPARG-28671TH Recombinant Human PPARG E.coli N/A
    Human PPARG-30104TH Recombinant Human PPARG, His-tagged E.coli His
    Human PPARG-31034TH Recombinant Human PPARG, His-tagged E.coli His
    Human PPARG-321H Recombinant Human PPARG protein, His/MBP-tagged E.coli His/MBP
    Human PPARG-492HCL Recombinant Human PPARG cell lysate Insect Cell N/A
    Human PPARG-4935H Recombinant Human PPARG Protein, His-tagged E. coli His
    Human PPARG-5244H Recombinant Human PPARG Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human PPARG-6217H Recombinant Human PPARG Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human PPARG-67H Recombinant Human PPARG, His-tagged E.coli HIS
    Human PPARG-68H Recombinant Human PPARG, 1-477aa, His-tagged E.coli His
    Human PPARG-7002H Recombinant Human PPARG, His & GST tagged Insect Cell His/GST
    Mouse PPARG-13162M Recombinant Mouse PPARG Protein Mammalian Cell His
    Mouse Pparg-39M Recombinant Mouse Pparg protein, His-tagged E.coli His
    Mouse Pparg-5030M Recombinant Mouse Pparg Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Rat PPARG-4593R Recombinant Rat PPARG Protein Mammalian Cell His
    Rat Pparg-7879R Recombinant Rat Pparg protein, His-tagged E.coli His
    Cynomolgus Monkey PPARG-804C Recombinant Cynomolgus PPARG Protein, His-tagged Mammalian Cell His
    Rhesus Macaque PPARG-3537R Recombinant Rhesus monkey PPARG Protein, His-tagged Mammalian Cell His
    Chicken PPARG-1103C Recombinant Chicken PPARG Mammalian Cell His
    Rabbit PPARG-7880R Recombinant Rabbit PPARG protein, His-tagged E.coli His
    Zebrafish PPARG-9032Z Recombinant Zebrafish PPARG Mammalian Cell His
    Cattle PPARG-7878C Recombinant Cattle PPARG protein, His-tagged E.coli His
    CBCRY34 Peroxisome Proliferator-activated Receptor Gamma E.coli N/A

    pparg involved in several pathways and played different roles in them. We selected most pathways pparg participated on our site, such as PPAR signaling pathway, AMPK signaling pathway, Osteoclast differentiation, which may be useful for your reference. Also, other proteins which involved in the same pathway with pparg were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    PPAR signaling pathway RXRBA; PPARA; Scd2; PLIN1; ACAA1; LPL; CYP27A1; ADIPOQ; RXRB; Scd1
    AMPK signaling pathway RAB11B; RPS6KB2; HNF4A; PPP2CA; IRS2; LEPR; CPT1A; IRS4; RPTOR; STRADA
    Osteoclast differentiation SFPI1; FCGR1; PIK3R5; FHL2; MAPK13; SIRPA; TNFSF11; MAPK3; MAP3K14; PPP3CC
    Huntingtons disease NDUFB7; HDAC2; NDUFA3; NDUFB1; SLC25A5; NDUFB4; TBP; HTT; CREB5; SOD1
    Pathways in cancer ITGAV; NFKB2; PRKCB; Fgf15; RASGRP3; FGF17; WNT1; STAT3; MMP1A; RAC2
    Transcriptional misregulation in cancer MEIS1; Pdgfa&Pdgfb; LMO2; HDAC2; MMP3; RUNX1; PML; SLC45A3; WNT16; BMI1
    Thyroid cancer MAP2K2; RXRG; LEF1; TP53; CCDC6; NCOA4; CCND1; RXRA; TCF7; MAP2K1

    pparg has several biochemical functions, for example, DNA binding, RNA polymerase II regulatory region DNA binding, RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by pparg itself. We selected most functions pparg had, and list some proteins which have the same functions with pparg. You can find most of the proteins on our site.

    Function Related Protein
    DNA binding LUC7L3; MTF2; PHC3; SPI1A; AHR; TCEA3; ZFAND5B; NR0B1; HOXA13A; PC
    RNA polymerase II regulatory region DNA binding NPAS4; NKX2-1; PPARG; ATXN3L; NCOA1; TXK
    RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding NR2F1; PGR; NR2F6B; RORA; VDRA; NR2F6; Ar; PPARAB; PPARDB; RORB
    WW domain binding TCEAL2; PMEPA1; DAZAP2; SCNN1G; TCEAL3; SCNN1B; TCEAL1; TCEAL5; TNK2; DNM2
    activating transcription factor binding PSIP1; ATOH8; HDAC4; MEF2D; DGKQ; MEF2C; GATA4; HDAC7; ZFP516; EP300
    alpha-actinin binding MYOT; ADORA2A; ALMS1; PPARG; PKD2L1; MAGI1; KCNN2; RARA; LRRC10; XIRP2
    arachidonic acid binding S100A9; CYP4F14; ALOX5AP; S100A8; CYP4A14; STX3; PPARG
    chromatin binding MNT; HOXD13; EZH2; AIRE; SREBF1; BAP1; SUV39H1; SMARCA2; MEIS3; TCF3
    core promoter sequence-specific DNA binding TP53; C1orf51; MEOX1; THRAP3; H2AFY; NR1D2; ZFP932; MLL1; ZNF750; NRIP1
    drug binding CYP4B1; TYMS; HTR2B; UGT1A7; HMGCS1; ABP1; FOLR2; CHRNA2; DRD3; GPR30
    enzyme binding RAD9A; AKT1; CBX4; NCOA1; Txn1; TSPAN17; PDE4DIP; KMT2E; CCDC99; DVL1
    estrogen receptor binding NRIP1; CTNNB1; PPARGC1B; PHB2; FUS; MMS19; PADI2; TMEM38A; FOXL2; CNOT1
    ligand-dependent nuclear receptor transcription coactivator activity HMGA1; TSG101; PPARG; ACTN1; PSMC3IP; MED17; NCOA3; PKN1; PRKCBB; MED30
    metal ion binding PTS; LMO7A; CYP2AA4; NEK3; SUCLA2; ARHGAP29; GM5136; ATP1A1A.5; CYP17A2; ZBTB12.1
    protein binding CCT5; FGF10; ITGA3; THOC4; MXI1; KBTBD7; PTPRB; BNIP1; TNFAIP8L1; DCP1B
    protein phosphatase binding DLG3; TRAF3; NEK2; SHOC2; MAP2K7; CTNNB1; FGF19; KAT2A; PPP6R1; CDKN1B
    retinoid X receptor binding NCOR1; PPARG; NR1H2; VDR; NSD1; FUS; NR4A2; RARB; MED25; NR1H4
    contributes_to sequence-specific DNA binding EPAS1; FIGLA; SMAD4; HDAC4; PPARG; HIF1A; HNRNPAB; NEUROD1; TCF3; TRIM28
    steroid hormone receptor activity RORAB; OR51E2; RXRGA; ESRRGA; PGR; RORB; NR1I2; NR6A1A; ESR1; NR2F6A
    transcription factor activity, sequence-specific DNA binding UBP1; KLF9; LZTS1; NKX6-2; IKZF4; SNAPC5; NR3C1; HOXB3; SOX3; ZFP322A
    transcription factor binding PPP1R13BA; EP300; JUN; SIRT1; CCND1; DR1; HES4; SMAD3; E2F5; HDAC9
    transcription regulatory region DNA binding TOMM20A; ZFP161; GABPB1; Ar; FOXI1; SMAD7; ATF6B; CEBPA; HIVEP2A; CTCFL
    transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding NR1I3; LEF1; STAG2; ESRRG; GATA2B; MYOD1; CREB3L3; TP53; CREBBP; GATA1A
    zinc ion binding ZNF330; GCH1; LIMCH1; LHX1A; MMP1A; RNF34B; ZNRF2; PPARDB; TRIM55A; UBR7

    pparg has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with pparg here. Most of them are supplied by our site. Hope this information will be useful for your research of pparg.

    Sirt1; MED1; SIRT1; Prdm16; ucp1_mouse_gene

    Schneider, C; Nobs, SP; et al. Alveolar Macrophages Are Essential for Protection from Respiratory Failure and Associated Morbidity following Influenza Virus Infection. PLOS PATHOGENS 10:-(2014).
    Oysyannikova, IG; White, SJ; et al. Leptin and leptin-related gene polymorphisms, obesity, and influenza A/H1N1 vaccine-induced immune responses in older individuals. VACCINE 32:881-887(2014).

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