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Recombinant Human REN

Cat.No.: REN-73H
Product Overview: Recombinant Human Renin was expressed in Yeast.
Description: Renin is a member of the aspartyl proteinase family produced largely in part by the juxtaglomerular cells in the kidney.Renin differs from the other members of this class by having a pH optimum near neutral pH region with native substrates instead of 2.0 to 3.4 This more neutral pH optimum allows it to be functional in the plasma.Renin also has very high selectivity for substrate due to quite long peptide recognition on either side of the peptide bond undergoing cleavage. An octapeptide substrate was the minimum length to be cleaved by renin. Renin plays a crucial role in the regulation of blood pressure and salt balance through the cleavage of angiotensinogen, which is the only known physiological substrate of renin.
Source: Yeast
Species: Human
Form: Lyophilized from sterile 20mM PB,240mM NaCl,PH6.0.
Molecular Mass: 16.1kDa
Endotoxin: < 1.0 eu per μg of the protein as determined by the LAL method.
Purity: >95 % as determined by SDS-PAGE
Applications: Western blotting, ELISA
Storage: Store it under sterile conditions at -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.Samples are stable for up to twelve months from date of receipt at -80℃.
Gene Name: REN renin [ Homo sapiens ]
Official Symbol: REN
Synonyms: REN; renin; angiotensinogenase; renin precursor, renal; angiotensin-forming enzyme; HNFJ2; FLJ10761;
Gene ID: 5972
mRNA Refseq: NM_000537
Protein Refseq: NP_000528
MIM: 179820
UniProt ID: P00797
Chromosome Location: 1q32
Pathway: ACE Inhibitor Pathway, organism-specific biosystem; Renin-angiotensin system, organism-specific biosystem; Renin-angiotensin system, conserved biosystem;
Function: aspartic-type endopeptidase activity; insulin-like growth factor receptor binding; peptidase activity; receptor binding;

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