Recombinant Human REN Protein REN-52H

Recombinant Human REN Protein

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Recombinant Human REN Protein

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Cat.No. : REN-52H
Product Overview : Recombinant human REN(1-406) protein without tag was expressed in HEK293 cells.
Description : This gene encodes renin, an aspartic protease that is secreted by the kidneys. Renin is a part of the renin-angiotensin-aldosterone system involved in regulation of blood pressure, and electrolyte balance. This enzyme catalyzes the first step in the activation pathway of angiotensinogen by cleaving angiotensinogen to form angiotensin I, which is then converted to angiotensin II by angiotensin I converting enzyme. This cascade can result in aldosterone release, narrowing of blood vessels, and increase in blood pressure as angiotension II is a vasoconstrictive peptide. Transcript variants that encode different protein isoforms and that arise from alternative splicing and the use of alternative promoters have been described, but their full-length nature has not been determined. Mutations in this gene have been shown to cause hyperuricemic nephropathy familial juvenile 2, familial hyperproreninemia, and renal tubular dysgenesis.
Source : HEK293
Species : Human
Molecular Mass : 45 kDa
Protein length : 1-406
Purity : ≥85% estimated by SDS-PAGE
Stability : ≥ 1 year
Storage : Store it at -80 centigrade
Storage Buffer : 50mM Tris-HCl pH 8.0, with 150 mM sodium chloride, 5% Glycerol
SDS-PAGE Analysis of REN :

Lane 1: MW Markers; Lane 2: Prorenin (1 μg); Lane 3: Prorenin (2 μg); Lane 4: Prorenin (4 μg). Representative gel image shown; actual purity may vary between each batch.

Gene Name : REN renin [ Homo sapiens (human) ]
Official Symbol : REN
Synonyms : REN; renin; HNFJ2; renin; angiotensin-forming enzyme; angiotensinogenase; renin precursor, renal
Gene ID : 5972
mRNA Refseq : NM_000537
Protein Refseq : NP_000528
MIM : 179820
UniProt ID : P00797

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