Recombinant Human REN Protein


Home / Products / Recombinant Proteins / Recombinant Human REN Protein

Recombinant Human REN Protein

REN Related Products

Price Inquiry

Welcome! For price inquiries, please feel free to contact us through the form below. We will get back to you as soon as possible.

Cat.No. : REN-56H
Product Overview : Recombinant human REN(67-406) protein without tag was expressed in HEK293 cells.
Description : This gene encodes renin, an aspartic protease that is secreted by the kidneys. Renin is a part of the renin-angiotensin-aldosterone system involved in regulation of blood pressure, and electrolyte balance. This enzyme catalyzes the first step in the activation pathway of angiotensinogen by cleaving angiotensinogen to form angiotensin I, which is then converted to angiotensin II by angiotensin I converting enzyme. This cascade can result in aldosterone release, narrowing of blood vessels, and increase in blood pressure as angiotension II is a vasoconstrictive peptide. Transcript variants that encode different protein isoforms and that arise from alternative splicing and the use of alternative promoters have been described, but their full-length nature has not been determined. Mutations in this gene have been shown to cause hyperuricemic nephropathy familial juvenile 2, familial hyperproreninemia, and renal tubular dysgenesis.
Source : HEK293
Species : Human
Molecular Mass : 40 kDa
Protein length : 67-406
Purity : ≥85% estimated by SDS-PAGE
Unit Definition : One unit is defined as the amount of enzyme that will liberate 1.0 nmol of EDANS per minute at 37 centigrade in 50 mM Tris-HCl, pH 8.0, containing 100 nM NaCl, and 10 μM of the fluorescent peptide Arg-Glu(EDANS)-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-ThrLys(dabcyl)-Arg. Renin is diluted with 50 mM Tris-HCl, pH 8.0, containing 100 nM NaCl before assaying in a final assay volume of 205 μL with a fluorescence microplate reader using an excitation wavelength of 340 nm and emission wavelength of 485 nm.
Stability : ≥ 1 year
Storage : Store it at -80 centigrade
Storage Buffer : 50 mM Tris, pH 8.0, with 150 mM NaCl and 5% glycerol
SDS-PAGE Analysis of REN :

Lane 1: MW Markers; Lane 2: Renin (4 μg); Lane 3: Renin (2 μg). Representative gel image shown; actual purity may vary between each batch.

Renin Activity :

Gene Name : REN renin [ Homo sapiens (human) ]
Official Symbol : REN
Synonyms : REN; renin; HNFJ2; renin; angiotensin-forming enzyme; angiotensinogenase; renin precursor, renal
Gene ID : 5972
mRNA Refseq : NM_000537
Protein Refseq : NP_000528
MIM : 179820
UniProt ID : P00797
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

Online Inquiry

  • Note: There will be extra charge for optional service!

Optional Service: Optional requirements on this protein

Other Requirements:

Apply For A Coupon

$50 OFF Your First Purchase

Apply For a Coupon

Enter your email here to subscribe.

creative biomart inc.

Easy access to products and services you need from our library via powerful searching tools.

Follow Us

Copyright © 2021 Creative BioMart. All Rights Reserved. Terms and Conditions | Privacy Policy