Recombinant Human Renin

• Cat.No.: REN-5473H
• Product Overview: Recombinantlyproduced in HEK cell culture as untagged native form prorenin and purified byaffinity chromatography.

Specification

• Species: Human
• Source: HEK293
• Tag: Non
• Description: REN is aglycosylated aspartic protease that consists of 2 homologous lobes and is theprecursor of renin. Prorenin exhibits a low level of enzymatic activityrelative to renin which is generated from prorenin by proteolytic cleavage ofthe first 43 amino acids at the N-terminus. This so-called prosegment appearsto block the full enzymatic potential of the active site.
• Form: Frozen liquid in 10mM Tris Buffer + 0.1 M NaCl, pH 8.0.
• Purity: >95% by SDS-PAGEanalysis
• MolecularWeight: 43.725 kDa
• Endotoxin Level: < 0.1 ng/μg ofprotein
• Concentration: 1.0 mg/ml
• Storage: Store at -80°C.Stable for 3 years from delivery. Avoid repeated freeze-thaw cycles.
• OfficialSymbol: REN
• Pathways: ACE InhibitorPathway; Renin-angiotensin system

Gene Information

• Gene Name: REN renin [ Homo sapiens]
• Synonyms: REN;renin; HNFJ2; OTTHUMP00000034311; angiotensinogenase; reninprecursor, renal; angiotensin-forming enzyme; EC 3.4.23.15; Renin; Angiotensinogenase
• Gene ID: 5972
• mRNA Refseq: NM_000537
• Protein Refseq: NP_000528
• MIM: 179820
• UniProt ID: P00797
• Chromosome Location: 1q32
• Function: aspartic-typeendopeptidase activity; insulin-like growth factor receptor binding;peptidase activity; receptor binding