ren1

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ren1

Official Full Name Renin 1 Structural
Background Renin catalyzes the first step in the activation pathway of angiotensinogen--a cascade that can result in aldosterone release, vasoconstriction, and increase in blood pressure. Renin, an aspartyl protease, cleaves angiotensinogen to form angiotensin I, which is converted to angiotensin II by angiotensin I converting enzyme, an important regulator of blood pressure and electrolyte balance. Transcript variants that encode different protein isoforms and that arise from alternative splicing and the use of alternative promoters have been described, but their full-length nature has not been determined. Mutations in this gene have been shown to cause familial hyperproreninemia.
Synonyms Ren1; renin 1 structural; Ren; Rnr; Rn-1; Ren-1; Ren-A; Ren1c; Ren1d; D19352; renin-1; renin b; kidney renin; aspartyl-protease; OTTMUSP00000024128; angiotensinogenase; renin; EC 3.4.23.15; renin precursor, renal; HNFJ2; FLJ107612; EC 3.4.238; angiotensin-forming enzyme; Prorenin; FLJ10761; RENAA; Renin precursor renal; Angiotensin forming enzyme
    • Species :
    • Mouse
    • Source :
    • E.coli
    • HEK293
    • Human Cell
    • Insect Cell
    • Mammalian Cell
    • Tag :
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Mouse REN1-14072M Recombinant Mouse REN1 Protein Mammalian Cell His
    Mouse Ren1-2305M Recombinant Mouse Ren1 protein, His-tagged HEK293 His
    Mouse Ren1-379M Recombinant Mouse Ren1 Protein, His-tagged Insect Cell His
    Mouse Ren1-7885M Recombinant Mouse Ren1 protein, His-tagged E.coli His
    Mouse Ren1-7886M Recombinant Mouse Ren1 protein, His-tagged E.coli His
    Mouse REN-2576MCL Recombinant Mouse REN cell lysate Human Cell N/A

    ren1 involved in several pathways and played different roles in them. We selected most pathways ren1 participated on our site, such as Renin-angiotensin system, Renin secretion, which may be useful for your reference. Also, other proteins which involved in the same pathway with ren1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Renin-angiotensin system KLK2; KLK1B11; KLK1B22; MRGPRD; AGTR1A; ACE2; REN; KLK1B5; CMA1; PREP
    Renin secretion AGTR1B; PPP3CC; CALML5; PPP3R2; PDE1A; GNAI3; NPR1; GNAS; PPP3R1; PRKACG

    ren1 has several biochemical functions, for example, aspartic-type endopeptidase activity, endopeptidase activity, hydrolase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ren1 itself. We selected most functions ren1 had, and list some proteins which have the same functions with ren1. You can find most of the proteins on our site.

    Function Related Protein
    aspartic-type endopeptidase activity BACE2; BACE1; REN2; ASPRV1; PGA; Casp3; ANK2B; PSEN1; CTSE; CTSD
    endopeptidase activity SENP5; PSMB8; HTRA4; MME; CPNE1; SENP3B; PSEN1; TPP2; AP1S2; PSMB11
    hydrolase activity LIPK; ATP8B1; OTUD4; DDX3; GM5136; USP2A; YDJC; PLAUA; PSMC1A; CES3A
    insulin-like growth factor receptor binding SOCS1; IGF2; REN; Ren1; IRS1; INS; GNAS; IGF1; ARRB1; INSR
    peptidase activity KLK1B24; FURINB; MEP1A.2; PRSS59.1; F2RL1.1; PSMB11; CTS7; CTRC; TPP1; USP9
    receptor binding NPFFL; SRC; SRPX2; CADM4; PSPN; YES1; HILPDA; TESPA1; HMGCL; F7

    ren1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ren1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ren1.

    Ywhae

    Cuffe, JSM; Walton, SL; et al. The effects of gestational age and maternal hypoxia on the placental renin angiotensin system in the mouse. PLACENTA 35:953-961(2014).
    Xa, LK; Lacombe, MJ; et al. General lysosomal hydrolysis can process prorenin accurately. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY 307:R505-R513(2014).

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