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Ren1

  • Official Full Name

    Renin 1 Structural

  • Overview

    Renin catalyzes the first step in the activation pathway of angiotensinogen--a cascade that can result in aldosterone release, vasoconstriction, and increase in blood pressure. Renin, an aspartyl protease, cleaves angiotensinogen to form angiotensin I, which is converted to angiotensin II by angiotensin I converting enzyme, an important regulator of blood pressure and electrolyte balance. Transcript variants that encode different protein isoforms and that arise from alternative splicing and the use of alternative promoters have been described, but their full-length nature has not been determined. Mutations in this gene have been shown to cause familial hyperproreninemia.
  • Synonyms

    Ren1; renin 1 structural; Ren; Rnr; Rn-1; Ren-1; Ren-A; Ren1c; Ren1d; D19352; renin-1; renin b; kidney renin; aspartyl-protease; OTTMUSP00000024128; angiotensinogenase; renin; EC 3.4.23.15; renin precursor, renal; HNFJ2; FLJ107612; EC 3.4.238; angiotensin-forming enzyme; Prorenin; FLJ10761; RENAA; Renin precursor renal; Angiotensin forming enzyme;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Mouse
  • E.coli
  • HEK293
  • HEK293T
  • Human Cell
  • Insect Cell
  • Mammalian Cell
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Mouse REN1-14072M Recombinant Mouse REN1 Protein Mammalian Cell His
Mouse Ren1-379M Recombinant Mouse Ren1 Protein, His-tagged Insect Cell His
Mouse Ren1-7885M Recombinant Mouse Ren1 protein, His-tagged E.coli His Val110~Val221 (Accession # P06281)
Mouse Ren1-2305M Active Recombinant Mouse Ren1 protein, His-tagged HEK293 His Met1-Arg402
Mouse Ren1-7886M Recombinant Mouse Ren1 protein, His-tagged E.coli His Thr265~Tyr386 (Accession # P06281)
Mouse REN-2576MCL Recombinant Mouse REN cell lysate Human Cell N/A
Mouse Ren1-5461M Recombinant Mouse Ren1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse Ren1-7315M Recombinant Mouse Ren1 Protein, His-tagged Insect Cell His 22-402
Mouse REN1-809M Recombinant Mouse REN1 Protein HEK293 402
Mouse REN1-7522M Recombinant Mouse REN1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse REN1-7522M-B Recombinant Mouse REN1 Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Ren1 Related Articles

Ren1 involved in several pathways and played different roles in them. We selected most pathways Ren1 participated on our site, such as Renin-angiotensin system, Renin secretion, which may be useful for your reference. Also, other proteins which involved in the same pathway with Ren1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Renin-angiotensin systemKLK1B11;CPA3;KLK1B8;MAS1;REN2;THOP1;Ren1;REN;KLK1B22
Renin secretionCALM4;GNAI1;PRKACA;PRKG2;CLCA4;GNAI3;PPP3CA;PDE1C;CLCA1

Ren1 has several biochemical functions, for example, aspartic-type endopeptidase activity, endopeptidase activity, hydrolase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Ren1 itself. We selected most functions Ren1 had, and list some proteins which have the same functions with Ren1. You can find most of the proteins on our site.

Function Related Protein
aspartic-type endopeptidase activityBACE2;DDI2;ANK2B;Ren1;PGA4;REN2;Casp3;BACE1;ATP6AP2
endopeptidase activityADAM10;PSMB8F;HTRA3;CPS1;APH1B;PSMA1;PSMB7;PSMB8;CTSH
hydrolase activityDOM3Z;ABHD17B;ATAD1A;PTPN2A;DPEP3;ASAH1A;PLCH2;CAPN8;PPAPDC3
insulin-like growth factor receptor bindingYWHAH;REN;IGF2;IRS1;ARRB1;SOCS2;SHC1;INS;IGF3
peptidase activityADAM25;CTS7;KLK1B26;PCSK7;CASPBL;CASP8;OTUD4;MMP14B;F2RL1.1
receptor bindingNTF7;TENC1;RND1;CD2;DDO;H2-Q10;PVRL1A;TNFSF15;GDNF

Ren1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Ren1 here. Most of them are supplied by our site. Hope this information will be useful for your research of Ren1.

Ywhae

Cuffe, JSM; Walton, SL; et al. The effects of gestational age and maternal hypoxia on the placental renin angiotensin system in the mouse. PLACENTA 35:953-961(2014).
Xa, LK; Lacombe, MJ; et al. General lysosomal hydrolysis can process prorenin accurately. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY 307:R505-R513(2014).
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Customer Reviews (3)

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Reviews
07/25/2020

    With their meticulous documentation and support, I am confident that my utilization of the REN1 protein in clinical trials will meet all necessary regulations and guidelines.

    04/07/2018

      Their comprehensive certificates of analysis and safety data sheets serve as testaments to their commitment to ensuring the safety and integrity of their products.

      10/06/2016

        Their ability to accommodate the requirements of large-scale experiments and guarantee a steady supply streamlines my research operations, eliminating any concerns related to prospective shortages.

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