|Official Full Name||Renin 1 Structural|
|Background||Renin catalyzes the first step in the activation pathway of angiotensinogen--a cascade that can result in aldosterone release, vasoconstriction, and increase in blood pressure. Renin, an aspartyl protease, cleaves angiotensinogen to form angiotensin I, which is converted to angiotensin II by angiotensin I converting enzyme, an important regulator of blood pressure and electrolyte balance. Transcript variants that encode different protein isoforms and that arise from alternative splicing and the use of alternative promoters have been described, but their full-length nature has not been determined. Mutations in this gene have been shown to cause familial hyperproreninemia.|
|Synonyms||Ren1; renin 1 structural; Ren; Rnr; Rn-1; Ren-1; Ren-A; Ren1c; Ren1d; D19352; renin-1; renin b; kidney renin; aspartyl-protease; OTTMUSP00000024128; angiotensinogenase; renin; EC 18.104.22.168; renin precursor, renal; HNFJ2; FLJ107612; EC 3.4.238; angiotensin-forming enzyme; Prorenin; FLJ10761; RENAA; Renin precursor renal; Angiotensin forming enzyme|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
ren1 involved in several pathways and played different roles in them. We selected most pathways ren1 participated on our site, such as Renin-angiotensin system, Renin secretion, which may be useful for your reference. Also, other proteins which involved in the same pathway with ren1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Renin-angiotensin system||KLK2; KLK1B11; KLK1B22; MRGPRD; AGTR1A; ACE2; REN; KLK1B5; CMA1; PREP|
|Renin secretion||AGTR1B; PPP3CC; CALML5; PPP3R2; PDE1A; GNAI3; NPR1; GNAS; PPP3R1; PRKACG|
ren1 has several biochemical functions, for example, aspartic-type endopeptidase activity, endopeptidase activity, hydrolase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ren1 itself. We selected most functions ren1 had, and list some proteins which have the same functions with ren1. You can find most of the proteins on our site.
|aspartic-type endopeptidase activity||BACE2; BACE1; REN2; ASPRV1; PGA; Casp3; ANK2B; PSEN1; CTSE; CTSD|
|endopeptidase activity||SENP5; PSMB8; HTRA4; MME; CPNE1; SENP3B; PSEN1; TPP2; AP1S2; PSMB11|
|hydrolase activity||LIPK; ATP8B1; OTUD4; DDX3; GM5136; USP2A; YDJC; PLAUA; PSMC1A; CES3A|
|insulin-like growth factor receptor binding||SOCS1; IGF2; REN; Ren1; IRS1; INS; GNAS; IGF1; ARRB1; INSR|
|peptidase activity||KLK1B24; FURINB; MEP1A.2; PRSS59.1; F2RL1.1; PSMB11; CTS7; CTRC; TPP1; USP9|
|receptor binding||NPFFL; SRC; SRPX2; CADM4; PSPN; YES1; HILPDA; TESPA1; HMGCL; F7|
ren1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ren1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ren1.