Eel Calcitonin Reference standard

• Cat.No.: CALCA-91E
• Product Overview: Eel calcitonin has structural similarities with salmon calcitonin and, to date, research preparations have been evaluated with reference to the salmon calcitonin standard using the rat hypocalcaemia assay method. However, as salmon and eel calcitonins do have structural differences, which are likely to become evident if different in vivo or in vitro assay methods are used, a standard for eel calcitonin is required.

Specification

• Species: Eel
• Enzyme Unit: Each ampoule of the reference standard contains 88 International Units (by definition).
• Usage: For all practical purposes, each ampoule of the IS contains the same quantity of the substances listed. Dissolve the total contents of the ampoule in a known volume of a suitable solvent (buffer at pH 3.5) with carrier protein where extensive dilution is required. No attempt should be made to weigh out any portion of the freeze-dried material. For economy of use, it is recommended that the solution be sub-divided into several small containers, frozen rapidly e.g. in dry ice and stored at - 40°C or below. Careful evaluation will be needed to determine a feasible time of storage.
• Notes: This preparation is not for administration to humans. The preparation contains material of human origin, which has been tested and found negative for HBsAg, HIV antibody and HCV RNA by PCR. As with all materials of biological origin, this preparation should be regarded as potentially hazardous to health. It should be used and discarded according to your own laboratorys safety procedures. Such safety procedures probably will include the wearing of protective gloves and avoiding the generation of aerosols. Care should be exercised in opening ampoules or vials, to avoid cuts.
• Storage: Unopened ampoules should be stored at –20 °C . Please note: because of the inherent stability of lyophilized material, Creative Biomart may ship these materials at ambient temperature.

Gene Information

• Gene Name: calca calcitonin/calcitonin-related polypeptide, alpha [ Danio rerio ];
• Official Symbol: CALCA
• Synonyms: calc; cgrp; zgc:92886; calcitonin/calcitonin-related polypeptide, alpha; calcitonin; calcitonin/calcitonin-related polypeptide alpha
• Gene ID: 436744
• mRNA Refseq: NM_001002471
• Protein Refseq: NP_001002471
• Chromosome Location: chromosome: 7

Reviews

05/06/2022

Quality laboratory materials, on-time delivery, and the best customer service.

01/22/2021

Impressed by the product quality and quick delivery. Great job!

07/11/2019

I love their laboratory products, and the delivery is super speedy.

Q&As

What is the chemical structure of calcitonin, and how does it regulate calcium levels in the body?

CALCA is a peptide hormone. It regulates calcium levels by reducing bone resorption, which lowers blood calcium levels, and by enhancing calcium excretion by the kidneys.

How is calcitonin synthesized from the CALCA gene?

Calcitonin is synthesized from the CALCA gene through tissue-specific alternative RNA splicing of gene transcripts and cleavage of inactive precursor proteins.

What is the role of calcitonin gene-related peptide (CGRP), another product of CALCA?

CGRP functions as a vasodilator and plays a role in antimicrobial defense in addition to its role in neurovascular regulation.

How is CALCA production affected by changes in serum calcium levels?

An increase in serum calcium levels stimulates the secretion of CALCA to help reduce the excess calcium in the bloodstream.

Can you explain the relationship betweCALCA and parathyroid hormone (PTH)?

CALCA and PTH are antagonistic hormones. PTH increases blood calcium levels, whereas calcitonin reduces them. They work together to maintain calcium homeostasis.