"HIF1A" Related Products

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Recombinant Human HIF1A

Cat. No. : HIF1A-136H
Product Overview : Recombinant Humanhypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) produced inE.Coliis a single, non-glycosylated polypeptide chain. The protein contains 298(530-826) amino acids and has a molecular mass of 32.8 kDa. The protein migrates as a 40 kDa band on SDS-PAGE. The HIF1-A is purified by proprietary chromatographic techniques.
Description : Hypoxia-inducible factor-1 (HIF-1), identified as one of the transcription factors, has been found to play an essential role in oxygen homeostasis. HIF-1 is a heterodimer composed of HIF-1β subunit and one of three subunits(Hif-1α, Hif-2( or Hif-3)). The activation of Hif-1( is closely associated with a variety of tumors and oncogenic pathways. Hif-1( consists of DNA binding domain(DBD domain), Dimerization domain and C-terminla regulatiory domains, including two transactivation domains(TAD), an oxygen-dependent degradation(ODD) domain, and inhibitory domains.
Source : Escherichia Coli.
Amino Acid Sequence : MEFKLELVEK LFAEDTEAKN PFSTQDTDLD LEMLAPYIPM DDDFQLRSFD QLSPLESSSA SPESASPQST VTVFQQTQIQ EPTANATTTT ATTDELKTVT KDRMEDIKIL IASPSPTHIH KETTSATSSP YRDTQSRTAS PNRAGKGVIE QTEKSHPRSP NVLSVALSQR TTVPEEELNP KILALQNAQR KRKMEHDGSL FQAVGIGTLL QQPDDHAATT SLSWKRVKGC KSSEQNGMEQ KTIILIPSDL ACRLLGQSMD ESGLPQLTSY DCEVNAPIQG SRNLLQGEEL LRALDQVN.
Physical Appearance : Sterile filtered liquid formulation 1mg/ml.
Formulation : The HIF1A recombinant Human solution is formulated 20mM Tris pH-7.5 and 1mM DTT.
Purity : Greater than 95.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
Stability : Recombinant Human MOP1 although stable at 4°C for 30 days, should be stored desiccated below -20°C for periods greater than 30 days. Please avoid freeze-thaw cycles.
Gene Name : HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) [ Homo sapiens ]
Synonyms : HIF1A; hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor); HIF1; MOP1; PASD8; bHLHe78; HIF-1alpha; HIF1-ALPHA; Hypoxia-inducible factor 1 alpha;HIF1 alpha; ARNT-interacting protein; Member of PAS protein 1; Basic-helix-loop-helix-PAS protein; ARNT interacting protein; hypoxia-inducible factor 1 alpha isoform I.3; member of PAS superfamily 1; hypoxia-inducible factor 1, alpha subunit
Gene ID : 3091
mRNA Refseq : NM_001530
Protein Refseq : NP_001521
MIM : 603348
UniProt ID : Q16665
Chromosome Location : 14q21-q24
Pathway : Pathways in cancer; Renal cell carcinoma; mTOR signaling pathway
Function : Hsp90 protein binding; RNA polymerase II transcription factor activity, enhancer binding; histone acetyltransferase binding; protein heterodimerization activity; sequence-specific DNA binding; signal transducer activity; transcription factor binding

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