Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

HIF1A

  • Official Full Name

    hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)

  • Overview

    Hypoxia, a condition of low tissue O2 concentration, plays an important role in normal physiological processes and tumor formation. Under hypoxic conditions mammalian cells up regulate the expression of hypoxic genes, including induction of angiogenesis and a switch to anaerobic metabolism, in order to survive. HIF-1 (Hypoxia Inducible Factor-1) is one of the key regulators of the transcriptional response to oxygen deprivation (1). HIF-1 is composed of two subunits, HIF-1alphaand HIF-1beta also known as aryl hydrocarbon receptor nuclear translocator (ARNT)) that are members of the basic helix-loop-helix (bHLH) Per-Arnt-Sim (PAS) (bHLH-PAS) family of transcription factors. HIF-1 is essential for angiogenesis, embryonic development, and is associated with tumor progression, erythropoiesis, vascular development/remodeling, vasodilation, and glucose/energy metabolism. The over expression of HIF-1alphahas been demonstrated in many common human cancers including prostate and breast, in which HIF-1alpha levels are associated with increase vascularitry and tumor progression. Besides physiological hypoxia, genetic abnormalities frequently detected in human cancers, such as loss of function mutations (Von Hippel-Lindau, p53, and PTEN), are associated with induction of HIF1 activity and expression of HIF-1-inducible genes (1).
  • Synonyms

    HIF1A; hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor); hypoxia-inducible factor 1-alpha; bHLHe78; HIF 1alpha; HIF1; MOP1; PASD8; HIF-1-alpha; member of PAS protein 1; ARNT interacting protein; ARNT-interacting protein; member of PAS superfamily 1; PAS domain-containing protein 8; basic-helix-loop-helix-PAS protein MOP1; class E basic helix-loop-helix protein 78; hypoxia-inducible factor 1 alpha isoform I.3; hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor); HIF-1alpha; HIF1-ALPHA;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Cattle
  • Chicken
  • Human
  • Mouse
  • Pig
  • Rat
  • E. coli
  • E.coli
  • HEK293
  • Human
  • In Vitro Cell Free System
  • Insect Cell
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • Strep
  • His|GST
  • His|MBP
  • His|S
  • N/A
  • N
  • No tag
  • T7
  • TEV
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human HIF1A-107H Recombinant Human HIF1A, His-tagged E.coli His 1 to 735aa
Human HIF1A-136H Recombinant Human HIF1A E.coli N/A
Human HIF1A-2773H Recombinant Human HIF1A, 576-785 aa, His-tagged E.coli His
Human HIF1A-106H Recombinant Human HIF1A, GST-tagged Wheat Germ GST
Human HIF1A-155H Recombinant Human HIF1A protein, His/S-tagged E.coli His/S
Human HIF1A-640H Recombinant Human HIF1A Mammalian Cell His
Human HIF1A-3092H Recombinant Human HIF1A, His tagged E.coli His
Human HIF1A-6935H Recombinant Human Hypoxia Inducible Factor 1, Alpha Subunit (basic helix-loop-helix transcription factor) E.coli N/A 530-826aa
Human HIF1A-8501H Recombinant Human HIF1A, His-tagged E.coli His
Human HIF1A-145H Recombinant Human HIF1A protein, His-tagged E.coli His Arg575~Asn826
Human HIF1A-198H Recombinant Human HIF1A protein, GST-tagged E.coli GST 574-799aa
Human HIF1A-5020H Recombinant Human Hypoxia Inducible Factor 1, Alpha Subunit, His-tagged Human His
Human HIF1A-278H Recombinant Human HIF1A protein, His/MBP-tagged E.coli His/MBP 568-768 aa
Human HIF1A-280H Recombinant Human HIF1A protein, His/MBP-tagged E.coli His/MBP 1-89 aa
Human HIF1A-279H Recombinant Human HIF1A protein, His/MBP-tagged E.coli His/MBP 136-318 aa
Human HIF1A-787HCL Recombinant Human HIF1A cell lysate N/A
Human HIF1A-5279H Recombinant Human HIF1A protein, His-tagged E.coli His 579-826aa
Human HIF1A-01H Recombinant Full Length Human HIF1A Protein, N-GST-tagged Wheat Germ GST 1-735aa
Human HIF1A-22H Recombinant Human HIF1A Protein, T7-His-TEV-tagged E. coli T7-His-TEV
Human HIF1A-2240H Recombinant Human HIF1A Protein, His-tagged E.coli N-His Thr218-Thr506
Human HIF1A-0486H Recombinant Human HIF1A Protein (E2-N826), Tag Free Insect Cell No tag E2-N826
Human HIF1A-3111H Recombinant Human HIF1A Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human HIF1A-232HF Recombinant Full Length Human HIF1A Protein, GST-tagged In Vitro Cell Free System GST 1 a.a. - 735 a.a.
Human HIF1A-0487H Recombinant Human HIF1A Protein (E2-N826), His/Strep tagged Insect Cell His/Strep E2-N826
Human HIF1A-3111H-B Recombinant Human HIF1A Protein Pre-coupled Magnetic Beads HEK293
Human HIF1A-2941H Recombinant Human HIF1A Protein (Arg575-Asn826), His tagged E.coli His Arg575-Asn826
Mouse Hif1a-7717M Recombinant Mouse Hif1a protein, His-tagged E.coli His Arg588~Asn836 (Accession # Q61221)
Mouse Hif1a-154M Recombinant Mouse Hif1a protein, His/S-tagged E.coli His/S
Rat Hif1a-7720R Recombinant Rat Hif1a protein, His-tagged E.coli His Ser641~Asn810 (Accession # O35800)
Rat Hif1a-153R Recombinant Rat Hif1a protein, His/S-tagged E.coli His/S
Rat HIF1A-2841R Recombinant Rat HIF1A Protein Mammalian Cell His
Rat Hif1a-7719R Recombinant Rat Hif1a protein, His-tagged E.coli His Pro216~Val336
Rat HIF1A-2496R-B Recombinant Rat HIF1A Protein Pre-coupled Magnetic Beads HEK293
Rat HIF1A-2496R Recombinant Rat HIF1A Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Cattle HIF1A-7712C Recombinant Cattle HIF1A protein, His-tagged E.coli His Pro45~Arg180 (Accession # Q9XTA5)
Cattle HIF1A-7713C Recombinant Cattle HIF1A protein, His & MBP-tagged E.coli His/MBP Leu220~Asp349 (Accession # Q9XTA5)
Pig HIF1A-7718P Recombinant Pig HIF1A protein, His & GST-tagged E.coli His/GST Glu585~Asn824 (Accession # A0T1H6)
Chicken HIF1A-7715C Recombinant Chicken HIF1A protein, His-tagged E.coli His Asp238~Lys389 (Accession # Q9YIB9)
Chicken HIF1A-5870C Recombinant Chicken HIF1A Mammalian Cell His
Chicken HIF1A-7716C Recombinant Chicken HIF1A protein, His-tagged E.coli His Glu35~Val155 (Accession # Q9YIB9)
Chicken HIF1A-7714C Recombinant Chicken HIF1A protein, His-tagged E.coli His Ala641~Cys785 (Accession # Q9YIB9)
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • HIF1A Related Articles
  • HIF1A Related Research Area

HIF1A involved in several pathways and played different roles in them. We selected most pathways HIF1A participated on our site, such as HIF- signaling pathway, mTOR signaling pathway, Thyroid hormone signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with HIF1A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
HIF- signaling pathwayLDHA;CAMK2A;AKT1;ANGPT1;INSR;GAPDH;TEK;PDK1;CAMK2D
mTOR signaling pathwayVEGFAA;TSC1B;CAB39L;EIF4EA;PIK3CD;IGF1;EIF4BA;PIK3R5;AKT1S1
Thyroid hormone signaling pathwayMED12L;AKT2;MED17;ATP1A2;HDAC2;FOXO1;EP300;PLCD4;PIK3R1
Pathways in cancerPTGER3;LAMB3;MAPK1;GRB2;PAX8;GLI2;IL-8;LAMA3;GNG11
Proteoglycans in cancerFZD8;RRAS;PLAU;CDC42;RRAS2;ARHGEF1;WNT5B;PPP1R12C;FZD10
Renal cell carcinomaSOS1;ETS1;EGLN2;PDGFB;MAPK3;MAP2K2;TGFB3;ARNT2;GRB2
Central carbon metabolism in cancerMAP2K2;FLT3;SLC1A5;SLC2A2;MAP2K1;SLC16A3;PGAM2;PIK3CB;PFKM
Choline metabolism in cancerPLA2G4C;PLD1;DGKQ;WAS;SP1;RPS6KB1;PLCG1;MAP2K1;WASF1

HIF1A has several biochemical functions, for example, Hsp90 protein binding, enzyme binding, histone acetyltransferase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HIF1A itself. We selected most functions HIF1A had, and list some proteins which have the same functions with HIF1A. You can find most of the proteins on our site.

Function Related Protein
Hsp90 protein bindingPPID;GBP1;STUB1;ARNTL;ERBB2;AHR;PPEF2;CDC37;TELO2
enzyme bindingVAPB;AKIRIN2;KDM4C;TH;MAPT;RXRA;BIRC5;RAD9;HAND2
histone acetyltransferase bindingTRP53;EPAS1;CITED2;NR4A3;ZBTB7A;MTF1;EID1;GLI3;HIF1A
histone deacetylase bindingRELA;NUDT21;PKN2;CEBPA;HIF1A;D7ERTD443E;SIRT2;CEBPB;SUDS3
nuclear hormone receptor bindingMED1;SNW1;CRX;NCOA2;BUD31;MYOD1;CTNNB1;NCOA3;NCOA1
protein bindingLIN7A;RGS19;LRPAP1;TNFAIP8L1;MAPKBP1;SNRPC;RIPK3;UBE2O;THRAA
protein heterodimerization activityH3F3C;VEGFA;BMP2B;AHR;CEBPG;PDSS1;MAFG;GRIN1;TAF11
protein kinase bindingRPS6KA3;SOCS1;DNM2;FER;CDC25B;TRAF4;PRKAG2;IKBKB;TELO2
contributes_to sequence-specific DNA bindingHIF1A;ARNT;HDAC4;TRIM28;EPAS1;PPARG;HNRNPAB;FIGLA;TCF3
transcription factor activity, RNA polymerase II distal enhancer sequence-specific bindingTHRA;LEF1;USF2;CEBPB;SOX17;POU3F3;ATF2;GATA6;JUN
contributes_to transcription factor activity, RNA polymerase II distal enhancer sequence-specific bindingHIF1A;ARNT
transcription factor activity, RNA polymerase II transcription factor bindingMAMSTR;YAP1;LHX2;SMAD4;MYOCD;HIF1A;NACC2;GATA4;ZNF296
transcription factor activity, sequence-specific DNA bindingDMRTA2;KLF3;SHOX;PAX7;ATOH8;TCF7L1B;TCF3;ZNF167;POU1F1
transcription factor activity, transcription factor bindingFOXO1;ASCL1B;HIF1A;LDB1A;ASCL1A;NEUROG1;LDB2A;PER2;CRY1
transcription factor bindingNIF3L1;GATA2;PDX1;CEBPG;JUNB;RELA;HMGA1;STAT3;JUND
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific bindingIRF1;HOXC13;TFAP2A;TCF21;POU3F2;KLF13;MAFB;ONECUT3;ZIC3
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific bindingMAFA;FOXC1;PPARG;SOHLH2;PKNOX1;MAFF;MAFGB;HOXD8;IRF2
ubiquitin protein ligase bindingTRIB3;C10orf46;TNFRSF1B;KCNH2;UQCRC1;UBE2T;MDM2;TANK;RPA2

HIF1A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HIF1A here. Most of them are supplied by our site. Hope this information will be useful for your research of HIF1A.

VHL

Mimouna, S; Bazin, M; et al. HIF1A regulates xenophagic degradation of adherent and invasive Escherichia coli (AIEC). AUTOPHAGY 10:2333-2345(2014).
So, K; Chung, Y; et al. The effect of chronic prenatal hypoxia on the development of mature neurons in the cerebellum. JOURNAL OF NEURODEVELOPMENTAL DISORDERS 5:-(2013).
  • Q&As
  • Reviews

Q&As (7)

Ask a question
How does HIF1A contribute to metabolic reprogramming in cells? 09/01/2022

HIF1A shifts cellular metabolism from oxidative phosphorylation to glycolysis, conserving oxygen but producing less energy.

How does HIF1A influence immune responses under hypoxic conditions? 07/10/2021

HIF1A modulates immune cell function, influencing responses like inflammation and immune cell migration in hypoxic tissues.

What role does HIF1A play in angiogenesis? 04/28/2021

HIF1A upregulates the expression of angiogenic factors, promoting blood vessel formation to improve oxygen supply.

In what way is HIF1A implicated in cancer progression? 09/14/2020

In cancer, HIF1A promotes tumor growth, survival, and metastasis under low oxygen conditions.

What is the primary function of HIF1A in response to hypoxia? 08/27/2018

HIF1A activates the transcription of genes involved in oxygen delivery and metabolic adaptation to hypoxia.

How is HIF1A regulated at the post-translational level? 06/17/2018

Under normoxic conditions, HIF1A is rapidly degraded, but under hypoxia, it stabilizes, translocates to the nucleus, and activates target genes.

What therapeutic strategies are being developed to target HIF1A in diseases? 02/13/2018

Therapeutic strategies targeting HIF1A aim to inhibit its activity in cancer or enhance it in conditions like ischemic heart disease.

Customer Reviews (3)

Write a review
Reviews
03/19/2022

    Reliable product, satisfied customer.

    03/28/2021

      Good value for money.

      11/07/2018

        Product exceeded expectations.

        Ask a Question for All HIF1A Products

        Required fields are marked with *

        My Review for All HIF1A Products

        Required fields are marked with *

        logo

        FOLLOW US

        Terms and Conditions        Privacy Policy

        Copyright © 2024 Creative BioMart. All Rights Reserved.

        Contact Us

        • /

        Stay Updated on the Latest Bioscience Trends