Recombinant Human Non-metastatic Cells 1, Protein (NM23A)

• Cat.No.: NME1-485H
• Product Overview: Recombinant human NME1 was expressed inE.coliand purified by using conventional chromatography techniques. MW = 17.1 kDa (152aa).

Specification

• Cat. No.: NME1-485H
• Description: Non-metastatic cells 1 (NME1), also known as NM23-H1, originally identified as a candidate metastasis suppressor gene. NME1 is expressed in different tumor types where their levels have been alternatively associated with reduced or increased metastatic potential. Reductions in NME1 expression have been significantly associated with aggressive behavior in melanoma, breast, colon, and gastric carcinomas. On the contrary, high levels of NME1 gene expression are noted in the advanced stage of thyroid carcinomas.
• Source: E.coli.
• Amino Acid Sequence: MANCERTFIA IKPDGVQRGL VGEIIKRFEQ KGFRLVGLKF MQASEDLLKE HYVDLKDRPF FAGLVKYMHS GPVVAMVWEG LNVVKTGRVM LGETNPADSK PGTIRGDFCI QVGRNIIHGS DSVESAEKEI GLWFHPEELV DYTSCAQNWI YE.
• Form: Liquid. In 20mM Tris-HCl buffer (pH7.5) containing 1mM DTT,10% glycerol.
• Purity: > 95% by SDS – PAGE.
• Concentration: 1 mg/ml (determined by Bradford assay).
• Endotoxin Level: < 1.0 EU per 1 μg of protein (determined by LAL method ).
• Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.

Gene Information

• Gene Name: NME1 non-metastatic cells 1, protein (NM23A) expressed in [ Homo sapiens ]
• Synonyms: NME1; non-metastatic cells 1, protein (NM23A) expressed in; NB; AWD; NBS; GAAD; NM23; NDPKA; NDPK-A; NM23-H1; NDP kinase A; OTTHUMP00000174772; EC 2.7.4.6; NDK A; Tumor metastatic process-associated protein; Metastasis inhibition factor nm23; nm23-H1; Granzyme A-activated DNase
• Gene ID: 4830
• mRNA Refseq: NM_000269
• Protein Refseq: NP_000260
• MIM: 156490
• UniProt ID: P15531
• Chromosome Location: 17q21.33
• Pathway: Metabolic pathways; Purine metabolism; Metablism of nucleotid
• Function: ATP binding; GTP binding; deoxyribonuclease activity; gamma-tubulin binding; identical protein binding; kinase activity; magnesium ion binding; nucleoside diphosphate kinase activity; nucleotide binding; transferase activity