Recombinant Human NME1 Protein, GST-tagged

• Cat.No.: NME1-5924H
• Product Overview: Human NME1 full-length ORF ( AAH00293, 1 a.a. - 152 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: This gene (NME1) was identified because of its reduced mRNA transcript levels in highly metastatic cells. Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of A (encoded by this gene) and B (encoded by NME2) isoforms. Mutations in this gene have been identified in aggressive neuroblastomas. Two transcript variants encoding different isoforms have been found for this gene. Co-transcription of this gene and the neighboring downstream gene (NME2) generates naturally-occurring transcripts (NME1-NME2), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product. [provided by RefSeq
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 42.46 kDa
• AA Sequence: MANCERTFIAIKPDGVQRGLVGEII KRFEQKGFRLVGLKFMQASEDLLKE HYVDLKDRPFFAGLVKYMHSGPVVA MVWEGLNVVKTGRVMLGETNPADSK PGTIRGDFCIQVGRNIIHGSDSVES AEKEIGLWFHPEELVDYTSCAQNWI YE
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: NME1 non-metastatic cells 1, protein (NM23A) expressed in [ Homo sapiens ]
• Official Symbol: NME1
• Synonyms: NME1; non-metastatic cells 1, protein (NM23A) expressed in; nucleoside diphosphate kinase A; NM23; NM23 H1; NDP kinase A; granzyme A-activated DNase; metastasis inhibition factor nm23; tumor metastatic process-associated protein; NB; AWD; NBS; GAAD; NDKA; NDPKA; NDPK-A; NM23-H1
• Gene ID: 4830
• mRNA Refseq: NM_000269
• Protein Refseq: NP_000260
• MIM: 156490
• UniProt ID: P15531

Reviews

04/02/2022

Critical expertise in protein engineering, unmatched in quality.

10/28/2021

Reliable protein crystallization services, consistently yields exceptional results.

12/23/2018

Efficient protein purification, consistent yields, cost-effective for research.

Q&As

What role does NME1 play in DNA repair and the maintenance of genomic stability?

NME1 plays a role in DNA repair, contributing to genomic stability.

How does NME1 influence signal transduction in response to cellular stress?

NME1 modulates cellular responses to stress, affecting signal transduction pathways.

What is the impact of NME1 on apoptosis and cell survival pathways?

NME1 influences apoptosis and cell survival, impacting cell fate decisions.

How do alterations in NME1 expression or activity affect drug resistance in cancer therapy?

Changes in NME1 can impact drug resistance in cancer, affecting treatment efficacy.

What are the mechanisms by which NME1 modulates the immune response, especially in tumor immunity?

NME1 regulates the immune response, particularly in tumor immunity.

How does NME1 contribute to the metastatic potential of cancer cells?

NME1 affects the metastatic behavior of cancer cells, influencing their spread.

How does NME1 regulate nucleotide metabolism and cellular energy balance?

NME1 is involved in nucleotide metabolism, crucial for maintaining cellular energy balance.