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Recombinant Human Adrenergic, Beta-1-, Receptor, Flag-His

Cat. No. : ADRB1-1017H
Description : The human1-adrenoreceptor (1AR) is activated by the catecholamines epinephrine and norepinephrine and couples to the G-protein Gs to mediate adenylate cyclase activation. Theβ1AR exists as several polymorphic forms of which the Gly389 and Arg389 variants are among the best known. There is a controversy whether or not there are functional differences between the two β1AR polymorphisms. β1ARs are mainly found in the heart, kidney, and fat tissue. These receptors are involved in physiological processes such heart contraction, renin release and lipolysis. The protein contains a N-terminal FLAG-tag and a C- terminal his tag for immunological detection, to allow purification, and to provide additional protection against proteolysis.
Source : Sf9 insect cells.
Form : Membrane suspension. Supplied in 75 mM Tris-HCl Ph 7.4, 12.5 mM MgCl2 and 1Mm EDTA.
Activity : 14 pmol/mg.
Usage : For in vitro use only.
Storage : Quality guaranteed for 12 months store at - 80°C. Avoid freeze / thaw cycles
Gene Name : ADRB1 adrenergic, beta-1-, receptor [ Homo sapiens ]
Synonyms : ADRB1; adrenergic, beta-1-, receptor; RHR; B1AR; ADRB1R; BETA1AR;Beta-1 adrenergic receptor; Beta-1 adrenoceptor; Beta-1 adrenoreceptor; OTTHUMP00000020519; beta-1-adrenergic receptor
Gene ID : 153
mRNA Refseq : NM_000684
Protein Refseq : NP_000675
MIM : 109630
UniProt ID : P08588
Chromosome Location : 10q24-q26
Pathway : Calcium signaling pathway; Dilated cardiomyopathy; Endocytosis; Gap junction; Neuroactive ligand-receptor interaction
Function : G-protein coupled receptor activity; PDZ domain binding; beta1-adrenergic receptor activity; dopamine binding; drug binding; epinephrine binding; norepinephrine binding; protein binding; receptor activity

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