ADRB2

  • Official Full Name

    adrenoceptor beta 2, surface

  • Overview

    This gene encodes beta-2-adrenergic receptor which is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1.2. This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G protein-coupled receptor. This gene is intronless. Different polymorphic forms, point mutations, and/or downregulation of this gene are associated with nocturnal asthma, obesity and type 2 diabetes. [provided by RefSeq, Jul 2008]
  • Synonyms

    ADRB2; adrenoceptor beta 2, surface; BAR; B2AR; ADRBR; ADRB2R; BETA2AR; beta-2 adrenergic receptor; beta-2 adrenoceptor; beta-2 adrenoreceptor; catecholamine receptor; adrenoceptor beta 2 surface; adrenergic, beta-2-, receptor, surface;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Antibody
  • Protein Pre-coupled Magnetic Beads
  • Assay Kits
  • Bos taurus (Bovine)
  • Bovin
  • Canis lupus familiaris (Dog) (Canis familiaris)
  • Cavia porcellus (Guinea pig)
  • Cynomolgus Monkey
  • Felis catus (Cat) (Felis silvestris catus)
  • Human
  • Macaca mulatta (Rhesus macaque)
  • Meriones unguiculatus (Mongolian jird) (Mongolian gerbil)
  • Mesocricetus auratus (Golden hamster)
  • Mouse
  • Mus musculus (Mouse)
  • Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
  • Rat
  • Rattus norvegicus (Rat)
  • Rhesus Macaque
  • Sus scrofa (Pig)
  • Tscherskia triton (Greater long-tailed hamster)
  • E.coli
  • E.coli expression system
  • HEK293
  • In Vitro Cell Free System
  • In vitro E. coli expression system
  • Mammalian Cell
  • Wheat Germ
  • Flag|His
  • GST
  • His
  • His (Fc)
  • Avi
  • Flag
  • SUMO
  • N/A
  • N
  • B2M
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ADRB2-25H Recombinant Human ADRB2 protein Wheat Germ N/A
Human ADRB2-26H Recombinant Human ADRB2 protein, GST-tagged Wheat Germ GST 1 a.a. - 413 a.a.
Human ADRB2-34HCL Recombinant Human ADRB2 cell lysate N/A
Human ADRB2-30059TH Recombinant Human GNAQ Flag/His
Human ADRB2-31550TH Recombinant Human GNB1 Flag/His
Human ADRB2-2352H Recombinant Human ADRB2(G16R,E27Q) Full Length Transmembrane protein, His-SUMO-tagged In vitro E. coli expression system His-SUMO 1-413aa(G16R,E27Q)
Human ADRB2-4532H Recombinant Human ADRB2 protein, His-B2M-tagged E.coli N-His-B2M 330-413aa
Human ADRB2-1131HFL Recombinant Human ADRB2 protein, His&Flag-tagged HEK293 His&Flag 1-413 aa
Human ADRB2-707HF Recombinant Full Length Human ADRB2 Protein, GST-tagged In Vitro Cell Free System GST 413 amino acids
Human ADRB2-701HF Recombinant Full Length Human ADRB2 Protein In Vitro Cell Free System 413 amino acids
Mouse ADRB2-1386M Recombinant Mouse ADRB2 Protein Mammalian Cell His
Mouse ADRB2-366M Recombinant Mouse ADRB2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse ADRB2-366M-B Recombinant Mouse ADRB2 Protein Pre-coupled Magnetic Beads HEK293
Mouse Adrb2-88M Recombinant Mouse Adrb2 Protein, GST-tagged E.coli N-GST Pro330-Leu418
Rat Adrb2-89R Recombinant Rat Adrb2 Protein, His-tagged E.coli N-His Pro330-Leu418
Bos taurus (Bovine) RFL33431BF Recombinant Full Length Bovine Beta-2 Adrenergic Receptor(Adrb2) Protein, His-Tagged E.coli expression system His Full Length (1-418)
Bovin ADRB2-123B Recombinant Bovin ADRB2 protein, His-tagged E.coli His 424aa
Canis lupus familiaris (Dog) (Canis familiaris) RFL-12813CF Recombinant Full Length Dog Beta-2 Adrenergic Receptor(Adrb2) Protein, His-Tagged E.coli expression system His Full Length (1-415)
Cavia porcellus (Guinea pig) RFL13571CF Recombinant Full Length Guinea Pig Beta-2 Adrenergic Receptor(Adrb2) Protein, His-Tagged E.coli expression system His Full Length (1-418)
Cynomolgus Monkey ADRB2-280C Recombinant Cynomolgus ADRB2 Protein, His-tagged Mammalian Cell His
Cynomolgus Monkey ADRB2-30C-B Recombinant Cynomolgus Monkey ADRB2 Protein Pre-coupled Magnetic Beads HEK293
Cynomolgus Monkey ADRB2-30C Recombinant Cynomolgus Monkey ADRB2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Felis catus (Cat) (Felis silvestris catus) RFL3680FF Recombinant Full Length Cat Beta-2 Adrenergic Receptor(Adrb2) Protein, His-Tagged E.coli expression system His Full Length (1-418)
Macaca mulatta (Rhesus macaque) RFL7378MF Recombinant Full Length Macaca Mulatta Beta-2 Adrenergic Receptor(Adrb2) Protein, His-Tagged E.coli expression system His Full Length (1-415)
Meriones unguiculatus (Mongolian jird) (Mongolian gerbil) RFL-23292MF Recombinant Full Length Meriones Unguiculatus Beta-2 Adrenergic Receptor(Adrb2) Protein, His-Tagged E.coli expression system His Full Length (1-251)
Mesocricetus auratus (Golden hamster) RFL-422MF Recombinant Full Length Mesocricetus Auratus Beta-2 Adrenergic Receptor(Adrb2) Protein, His-Tagged E.coli expression system His Full Length (1-418)
Mus musculus (Mouse) RFL-29133MF Recombinant Full Length Mouse Beta-2 Adrenergic Receptor(Adrb2) Protein, His-Tagged E.coli expression system His Full Length (1-418)
Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri) RFL15128OF Recombinant Full Length Oncorhynchus Mykiss Beta-2 Adrenergic Receptor(Adrb2) Protein, His-Tagged E.coli expression system His Full Length (1-409)
Rattus norvegicus (Rat) RFL-18694RF Recombinant Full Length Rat Beta-2 Adrenergic Receptor(Adrb2) Protein, His-Tagged E.coli expression system His Full Length (1-418)
Rhesus Macaque ADRB2-260R Recombinant Rhesus monkey ADRB2 Protein, His-tagged Mammalian Cell His
Rhesus Macaque ADRB2-88R Recombinant Rhesus Macaque ADRB2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque ADRB2-88R-B Recombinant Rhesus Macaque ADRB2 Protein Pre-coupled Magnetic Beads HEK293
Sus scrofa (Pig) RFL36395SF Recombinant Full Length Pig Beta-2 Adrenergic Receptor(Adrb2) Protein, His-Tagged E.coli expression system His Full Length (1-418)
Tscherskia triton (Greater long-tailed hamster) RFL34013TF Recombinant Full Length Tscherskia Triton Beta-2 Adrenergic Receptor(Adrb2) Protein, His-Tagged E.coli expression system His Full Length (1-418)
Kit-0867 BCA Protein Quantification Kit (Enhanced) N/A
Kit-1086 Methyltransferase Activity Assay Kit (Colorimetric) N/A
Kit-1115 Total Phosphodiesterase Activity Assay Kit (Fluorometric) N/A
Kit-1114 Calcein AM Cell Viability Assay Kit (Fluorometric) N/A
Kit-1116 Carbonic Anhydrase (CA) Activity Assay Kit (Colorimetric) N/A
Kit-2185 ADRB2 Total GPCR Internalization Assay Kit N/A
Kit-2186 ADRB2 CHO-K1 β-Arrestin GPCR Assay Kit N/A
Kit-2187 cAMP ADRB2 (B2AR) CHO-K1 GPCR Assay Kit N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

ADRB2 involved in several pathways and played different roles in them. We selected most pathways ADRB2 participated on our site, such as Adrenergic signaling in cardiomyocytes, Adrenoceptors, Amine ligand-binding receptors, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADRB2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Adrenergic signaling in cardiomyocytesAGTR1B;TNNT2;PPP2R3A;CAMK2A;CALML5;ADCY9;PRKACG;GNAI2A;RAPGEF3
AdrenoceptorsADRA2B;ADRa1A;ADRA1D;ADRA1B;ADRB3;ADRA2A;ADRA2C;ADRB2;ADRB1
Amine ligand-binding receptorsCHRM5;CHRM3;DRD2;ADRA1B;ADRA1D;DRD4;CHRM2;ADRA2B;ADRB3
Arf6 signaling eventsADRB2;GULP1;EPHA2;ARAP2;EFNA1;FBXO8;AGTR1;USP6;KIF13B
Arf6 trafficking eventsADRB2;CTNNA1;SPAG9;CTNND1;CHRM2;JUP;PTBP3;EXOC1;EXOC6
Calcium Regulation in the Cardiac CellRGS10;CX55.5;CX27.5;RGS7;RGS18;GJA10;GNG13B;RGS5;CX30.3
Calcium signaling pathwayMYLK;ATP2A2A;STIM1;ATP2B2;ADRA1B;RYR3;NOS2A;PTGER1B;PLCD3A
Class A/1 (Rhodopsin-like receptors)NMBB;OPN4;CCK;PROKR2;LTB4R;OPN1LW;NPSR1;GPR55A;CCR1

ADRB2 has several biochemical functions, for example, B2 bradykinin receptor binding, G-protein alpha-subunit binding, adenylate cyclase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ADRB2 itself. We selected most functions ADRB2 had, and list some proteins which have the same functions with ADRB2. You can find most of the proteins on our site.

Function Related Protein
B2 bradykinin receptor binding
G-protein alpha-subunit bindingNUCB1;RIC8A;RGS4;AGTR1A;RIC8;HTR2B;HTR2A;RGS19;PPP5C
adenylate cyclase bindingAKAP6;ADRB2;AKAP12;CALM2;ADCYAP1R1;CHRNA7;AKAP5;CALM1;CALM3
beta2-adrenergic receptor activityADRB2;ADRB2A;ADRB2B
dopamine bindingDRD4;SLC6A3;DRD1;ADRB2;DRD5;DRD3;DRD2A;DRD1B;DRD2
drug bindingRARB;ABP1;UGT1A7;FABP1;DCK;DAAM2;FOLR2;PPARA;PDXK
epinephrine bindingADRB2;ADRB3A;ADRB2B;ADRA2A;ADRA2C;ADRB3;ADRB2A;ADRB3B;ADRB1
ionotropic glutamate receptor bindingIL1R1;RAB4A;SHANK1;FLOT2;DLG1;DLG4B;DLG2;CANX;NETO1
norepinephrine bindingADRB1;ADRA2A;ADRB3A;ADRB3B;ADRB2
potassium channel regulator activityKCNMB3;CHP;KCNMB1;ABCC9;KCNIP1;SGK2;KCNS3;SGK2B;SGK2A
protein bindingNVL;PIK3IP1;RNF5;ATM;INTS10;HAUS1;KAT8;HDAC1;TRIM21
protein complex bindingRPAIN;CALCA;TUBB;EP300;FADD;RBX1;SHARPIN;EPHB1;DAG1
protein homodimerization activityTOP2A;CADM4;RBM44;BOKA;SRF;TESC;MID2;PRKG2;CSF1R

ADRB2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADRB2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ADRB2.

MAGI3; SRC; SLC9A3R1; ARRB2

Gene Family

GPCRs

Research Area

Related articles

Hassan, S; Karpova, Y; et al. A pilot study of blood epinephrine levels and CREB phosphorylation in men undergoing prostate biopsies. INTERNATIONAL UROLOGY AND NEPHROLOGY 46:505-510(2014).
Lantsova, VB; Gerasimov, AS; et al. The Role of ADRB2 in Myasthenia: Genetic and Immunological Factors. BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE 154:351-353(2013).
  • Reviews
  • Q&As

Customer Reviews (4)

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Reviews
09/18/2020

    The ADRB2 protein is of exceptional quality and is perfectly suited for my experimental requirements.

    09/24/2019

      Their excellent technical support has helped me overcome any challenges I have encountered, and I have full faith in their products and services.

      06/29/2018

        I am confident that this product will deliver accurate and reliable results.

        05/19/2018

          I look forward to continuing to work with them in the future and exploring their other offerings.

          Q&As (13)

          Ask a question
          How are drugs that target ADRB2 receptors used in disease treatment? 02/04/2023

          Drugs that target ADRB2 receptors, known as beta-2 agonists, are commonly used in the treatment of asthma, COPD, and other respiratory diseases. Selective ADRB2 agonists such as salmeterol and formoterol have also been used to treat chronic heart failure and metabolic disorders such as diabetes and obesity. However, chronic activation of ADRB2 signaling can lead to receptor desensitization and potentially adverse effects such as cardiac arrhythmias and metabolic dysfunction.

          How do ADRB2 receptors impact exercise performance? 04/12/2022

          ADRB2 receptors play a role in regulating exercise performance by mediating the effects of adrenaline and noradrenaline on the cardiovascular and respiratory systems. Activation of ADRB2 receptors can increase heart rate and blood flow to the muscles, as well as dilate the airways to improve oxygen uptake. Polymorphisms in the ADRB2 gene have been associated with differences in exercise performance, with some variants associated with improved endurance and others with decreased performance.

          How do ADRB2 receptors impact cardiac function? 08/15/2021

          ADRB2 receptors are primarily expressed in the heart's ventricular muscle tissue, where they regulate heart rate and contractility. Activation of ADRB2 receptors can increase heart rate and contractility, while desensitization of these receptors can lead to reduced cardiac function and increased risk of heart failure. Polymorphisms in the ADRB2 gene have also been associated with differences in risk of cardiovascular disease and response to beta blocker therapy.

          What are polymorphisms in the ADRB2 gene and how do they impact drug response? 07/17/2021

          Polymorphisms are variations in the DNA sequence of a gene that can lead to differences in protein expression or function. Several polymorphisms have been identified in the ADRB2 gene, some of which have been shown to impact drug response. For example, the Arg16Gly and Gln27Glu polymorphisms have been associated with decreased response to beta-2 agonist drugs in asthma patients. Other polymorphisms, such as the Thr164Ile and Gly16Arg variants, have been associated with improved treatment response.

          What are the potential side effects of drugs that target ADRB2 receptors? 12/01/2020

          Some potential side effects of drugs that target ADRB2 receptors include tremors or shakiness, increased heart rate, insomnia, and arrhythmias. Long-term use of ADRB2 agonists can also lead to receptor desensitization and decreased response to therapy over time. In rare cases, severe allergic reactions or bronchospasm can occur.

          How do ADRB2 receptors impact bone density? 06/20/2018

          ADRB2 receptors are also expressed in bone cells, where they play a role in regulating bone density. Activation of ADRB2 receptors can stimulate the formation of new bone cells and increase bone mineral density, while receptor desensitization can result in decreased bone density and increased risk of osteoporosis. Polymorphisms in the ADRB2 gene have also been associated with differences in bone density and risk of osteoporosis.

          How are ADRB2 antagonists used in asthma treatment? 02/10/2018

          ADRB2 antagonists, also known as beta blockers, are not used to treat asthma as they can exacerbate airway constriction. Instead, short-acting ADRB2 agonists such as albuterol are used to relieve bronchospasms and improve breathing, while long-acting ADRB2 agonists such as salmeterol are used as maintenance therapy to prevent asthma symptoms.

          How are ADRB2 agonists used in labor and delivery? 12/06/2017

          ADRB2 agonists such as terbutaline and ritodrine are sometimes used during labor to relax the uterus and prevent preterm labor. However, the use of these drugs for this purpose is controversial due to concerns about potential side effects such as maternal heart failure and fetal tachycardia. These drugs are typically administered as a temporary measure until other interventions such as corticosteroids can be used.

          How do drugs that target ADRB2 receptors interact with other medications? 07/05/2017

          Drugs that target ADRB2 receptors can interact with other medications that impact the sympathetic nervous system, such as beta blockers or alpha-adrenergic agonists. For example, taking a beta blocker along with a beta-2 agonist can lead to decreased effectiveness of the beta-2 agonist. Additionally, some medications such as monoamine oxidase inhibitors (MAOIs) can lead to increased norepinephrine levels and potentially severe cardiovascular effects when taken with ADRB2 agonists.

          Can ADRB2 agonists be used for weight loss? 05/18/2017

          ADRB2 agonists have been studied for their potential as weight loss aids, as they can increase metabolic rate and promote lipolysis (the breakdown of fat). However, long-term use of ADRB2 agonists for weight loss is not recommended due to the risk of side effects such as cardiac arrhythmias and increased blood pressure.

          Are there any alternative treatments for conditions that are commonly treated with ADRB2 agonists? 02/19/2017

          Alternative treatments for conditions such as asthma and COPD include inhaled corticosteroids and non-steroidal anti-inflammatory drugs (NSAIDs). Newer medications targeting different pathways, such as muscarinic receptor antagonists, have also been approved for the treatment of COPD. In some cases, lifestyle modifications such as smoking cessation and weight loss can also improve respiratory symptoms and reduce the need for medications.

          How do ADRB2 receptors impact mood? 10/21/2016

          ADRB2 receptors are also involved in regulating mood, with activation of these receptors being associated with increased feelings of alertness and arousal. Polymorphisms in the ADRB2 gene have been associated with differences in mood, including risk of depression and anxiety disorders. ADRB2 agonists such as salbutamol have been studied for their potential as mood enhancers, but further research is needed to confirm their efficacy and safety in this context.

          How do ADRB2 agonists impact glucose metabolism? 07/12/2016

          ADRB2 agonists can influence glucose metabolism by promoting glycogenolysis (the breakdown of stored glucose) and stimulating insulin secretion from pancreatic beta cells. Long-term use of ADRB2 agonists has been associated with increased risk of insulin resistance and type 2 diabetes, likely due to receptor desensitization and downregulation of insulin receptors.

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