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Official Full Name adrenoceptor beta 2, surface
Background This gene encodes beta-2-adrenergic receptor which is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1.2. This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G protein-coupled receptor. This gene is intronless. Different polymorphic forms, point mutations, and/or downregulation of this gene are associated with nocturnal asthma, obesity and type 2 diabetes. [provided by RefSeq, Jul 2008]
Synonyms ADRB2; adrenoceptor beta 2, surface; BAR; B2AR; ADRBR; ADRB2R; BETA2AR; beta-2 adrenergic receptor; beta-2 adrenoceptor; beta-2 adrenoreceptor; catecholamine receptor; adrenoceptor beta 2 surface; adrenergic, beta-2-, receptor, surface;
    • Species :
    • Cynomolgus Monkey
    • Human
    • Mouse
    • Rhesus Macaque
    • Source :
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • Flag
    • His
    • GST
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human ADRB2-25H Recombinant Human ADRB2 protein Wheat Germ N/A
    Human ADRB2-26H Recombinant Human ADRB2 protein, GST-tagged Wheat Germ GST
    Human ADRB2-30059TH Recombinant Human GNAQ Flag/His
    Human ADRB2-31550TH Recombinant Human GNB1 Flag/His
    Human ADRB2-34HCL Recombinant Human ADRB2 cell lysate N/A
    Mouse ADRB2-1386M Recombinant Mouse ADRB2 Protein Mammalian Cell His
    Cynomolgus Monkey ADRB2-280C Recombinant Cynomolgus ADRB2 Protein, His-tagged Mammalian Cell His
    Rhesus Macaque ADRB2-260R Recombinant Rhesus monkey ADRB2 Protein, His-tagged Mammalian Cell His
    Kit-0867 BCA Protein Quantification Kit (Enhanced) N/A
    Kit-1086 Methyltransferase Activity Assay Kit (Colorimetric) N/A
    Kit-1114 Calcein AM Cell Viability Assay Kit (Fluorometric) N/A
    Kit-1115 Total Phosphodiesterase Activity Assay Kit (Fluorometric) N/A
    Kit-1116 Carbonic Anhydrase (CA) Activity Assay Kit (Colorimetric) N/A
    Kit-2185 ADRB2 Total GPCR Internalization Assay Kit N/A
    Kit-2186 ADRB2 CHO-K1 β-Arrestin GPCR Assay Kit N/A
    Kit-2187 cAMP ADRB2 (B2AR) CHO-K1 GPCR Assay Kit N/A

    adrb2 involved in several pathways and played different roles in them. We selected most pathways adrb2 participated on our site, such as Adrenergic signaling in cardiomyocytes, Adrenoceptors, Amine ligand-binding receptors, which may be useful for your reference. Also, other proteins which involved in the same pathway with adrb2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Adrenergic signaling in cardiomyocytes GNAI2; PPP1R1A; SCN1B; PPP1CB; GNA15.1; GNAS; PPP2R2BB; ADRB3B; PIK3R3; MAPK12
    Adrenoceptors ADRA1D; ADRA1B; ADRA2C; ADRA2A; ADRB1; ADRA2B; ADRa1A; ADRB3; ADRB2
    Amine ligand-binding receptors ADRB3; DRD1; CHRM2; DRD2; ADRB2; DRD3; ADRA2B; CHRM5; ADRB1; HRH3
    Arf6 signaling events KIF13B; EGFR; EPHA2; ADAP1; IPCEF1; USP6; ADRB2; GULP1; EFNA1; ARAP2
    Arf6 trafficking events EDNRB; PTBP3; SCAMP2; CTNNA1; EXOC3; CTNND1; ADRB2; DNM2; SPAG9; JUP
    Calcium Regulation in the Cardiac Cell CHRM1; PKIG; CASQ2; GJB6; RGS10; RGS16; GJA3; ADRa1A; GNB3B; GJB4
    Calcium signaling pathway AKR1C1; CACNA1C; PHKG1B; GNA14; TACR2; LHCGR; ADRB2; ATP2B2; EDNRA; F2R
    Class A/1 (Rhodopsin-like receptors) CHRM2; CCR3; CHRM4; CCL19A.2; DRD4; PROKR2; OPN1LW2; RLN3A; ADORA2A; ZFPM2B

    adrb2 has several biochemical functions, for example, B2 bradykinin receptor binding, G-protein alpha-subunit binding, adenylate cyclase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by adrb2 itself. We selected most functions adrb2 had, and list some proteins which have the same functions with adrb2. You can find most of the proteins on our site.

    Function Related Protein
    B2 bradykinin receptor binding ADRB2
    G-protein alpha-subunit binding PPP5C; AGTR1A; RIC8; NUCB1; RIC8A; DRD1A; HTR2A; F2RL1; DRD1; RIC8B
    adenylate cyclase binding AKAP5; ADRB2; AKAP12; AKAP6; CALM2; CALM1; CHRNA7; CALM3; ADCYAP1R1
    beta2-adrenergic receptor activity ADRB2; ADRB2B; ADRB2A
    dopamine binding DRD3; DRD5; GPR143; DRD4; DRD2; TH; ADRB2; DRD2L; DRD1B; DRD2A
    drug binding HMGCS1; PPARA; CHRNA3; CYP2D6; UGT1A7; MT2A; FSCN1; GSTP2; MT3; HMGB2
    epinephrine binding ADRB2; ADRB2B; ADRB2A; ADRA2A; ADRB1; ADRB3B; ADRA2C; ADRB3; ADRA2B; ADRB3A
    ionotropic glutamate receptor binding DLG1; SHANK3; SHANK1; DLG3; DLG4B; DLG4; CACNG2; CANX; SHANK2; NETO1
    norepinephrine binding ADRB3B; ADRB1; ADRB3A; ADRB2; ADRA2A
    potassium channel regulator activity KCNE3; DLG1; KCNAB3; ARPP19A; YWHAE; ABCC9; DPP10; KCNIP4; AMIGO1; KCNE1
    protein binding IRF5; C10orf137; RPL19; CRIPAK; CENPW; PVRL3; FGFBP1; C18orf1; GCH1; B4GALT7
    protein complex binding CDKN1A; RAP1B; MTHFR; CPS1; ABI1; ERCC6; ITPR1; KHDRBS1; PPARA; CCNE1
    protein homodimerization activity PYCARD; SLC6A4; PON3; LRRC41; USH2A; SNX1; Trl; BMP4; TSC2; PVRL2L

    adrb2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with adrb2 here. Most of them are supplied by our site. Hope this information will be useful for your research of adrb2.


    Hassan, S; Karpova, Y; et al. A pilot study of blood epinephrine levels and CREB phosphorylation in men undergoing prostate biopsies. INTERNATIONAL UROLOGY AND NEPHROLOGY 46:505-510(2014).
    Lantsova, VB; Gerasimov, AS; et al. The Role of ADRB2 in Myasthenia: Genetic and Immunological Factors. BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE 154:351-353(2013).

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