ADRB1
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Official Full Name
adrenergic, beta-1-, receptor
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Overview
The adrenergic receptors (subtypes alpha 1, alpha 2, beta 1, and beta 2) are a prototypic family of guanine nucleotide binding regulatory protein-coupled receptors that mediate the physiological effects of the hormone epinephrine and the neurotransmitter norepinephrine. Specific polymorphisms in this gene have been shown to affect the resting heart rate and can be involved in heart failure. -
Synonyms
ADRB1; adrenergic, beta-1-, receptor; beta-1 adrenergic receptor; ADR B1; ADRB 1; ADRB1_HUMAN; ADRB1R; Adrenergic beta 1 receptor; B1AR; Beta 1 adrenoceptor; Beta 1 adrenoreceptor; Beta-1 adrenoceptor; Beta-1 adrenoreceptor; BETA1AR; RHR;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Assay Kits
- Bos taurus (Bovine)
- Canis lupus familiaris (Dog) (Canis familiaris)
- Felis catus (Cat) (Felis silvestris catus)
- Homo sapiens (Human)
- Human
- Macaca mulatta (Rhesus macaque)
- Meleagris gallopavo (Wild turkey)
- Meriones unguiculatus (Mongolian jird) (Mongolian gerbil)
- Mouse
- Mus musculus (Mouse)
- Ovis aries (Sheep)
- Rat
- Rattus norvegicus (Rat)
- Rhesus Macaque
- Sus scrofa (Pig)
- Xenopus laevis (African clawed frog)
- Zebrafish
- E.coli expression system
- HEK293
- In vitro E. coli expression system
- Insect Cell
- Mammalian Cell
- Sf9 Insect Cell
- Yeast
- Flag|His
- His
- His (Fc)
- Avi
- Flag
- SUMO
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- ADRB1 Related Gene Family
- ADRB1 Related Research Area
ADRB1 involved in several pathways and played different roles in them. We selected most pathways ADRB1 participated on our site, such as Adrenergic signaling in cardiomyocytes, Adrenoceptors, Amine ligand-binding receptors, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADRB1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Adrenergic signaling in cardiomyocytes | ADCY7;MAPK14;SCN1B;MAPK12;TPM4;CALM;TNNT2;CACNG7;PPP1CAA |
Adrenoceptors | ADRA1D;ADRB2;ADRA1B;ADRA2A;ADRA2B;ADRa1A;ADRB1;ADRA2C;ADRB3 |
Amine ligand-binding receptors | CHRM5;TAAR1;ADRB2;ADRB1;ADRA2A;DRD1;ADRA1D;ADRB3;ADRA1B |
Calcium Regulation in the Cardiac Cell | CHRM4;CX27.5;GJB3;GJC2;ADRA1D;FKBP1A;CX34.4;ADRa1A;RGS17 |
Calcium signaling pathway | GRIN2A;PTGFR;CACNA1H;PTGER1C;SLC8A2;PRKCG;TMEM8C;PLCB2;SLC8A1 |
Class A/1 (Rhodopsin-like receptors) | OPN1MW2;GPR4;PROK1;S1PR1;CCR5;OPN4;OPN5;S1PR3;GPBAR1 |
Dilated cardiomyopathy | ACTG1;CACNB2;CACNA2D4;GNAS;ACTC1;DMD;PLN;ITGA3;CACNG3 |
Endocytosis | RHOAB;RET;CXCR4A;HSPA1L;ACAP3;SH3GLB1A;RAB31;CCR5;WIPF2B |
ADRB1 has several biochemical functions, for example, PDZ domain binding, Ras guanyl-nucleotide exchange factor activity, alpha-2A adrenergic receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ADRB1 itself. We selected most functions ADRB1 had, and list some proteins which have the same functions with ADRB1. You can find most of the proteins on our site.
Function | Related Protein |
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PDZ domain binding | GRID2;PTENA;ACOX1;ATP2B3A;FZD1;SDC2;ATP2B3B;PTEN;LLGL2 |
Ras guanyl-nucleotide exchange factor activity | RASGEF1BA;RASGEF1BB;RAPGEF5;RAB3A;RASGEF1B;SOS1;RASGEF1A;RASGRP4;ADRB1 |
alpha-2A adrenergic receptor binding | APLP1;ADRB1;ADRBK1;ADRA2C;UCHL1 |
beta-adrenergic receptor activity | ADRB1;ADRB3 |
beta1-adrenergic receptor activity | |
epinephrine binding | ADRA2C;ADRA2A;ADRB1;ADRB3A;ADRB2B;ADRB3;ADRB2A;ADRA2B;ADRB3B |
norepinephrine binding | ADRB2;ADRB3B;ADRB3A;ADRB1;ADRA2A |
protein binding | HLA-DRB3;HLCS;NELL1;UPRT;SPAST;UBA1;ITPRIPL1;WAPAL;ABCF1 |
protein heterodimerization activity | SUPT4H1;H3F3A;KCNA3;RRAGC;H2-AB1;ITGA3;ADD2;CHRNA3;ABCG1 |
receptor signaling protein activity | TYROBP;KLK1B4;RGS14;NSMAF;DAXX;RGS14A;Siglece;SMAD1;RAF1A |
ADRB1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADRB1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ADRB1.
MAGI2; MAGI3; Dlg4; GPRASP1; Dlg1; GPRASP2; MAGI1; GOPC; Gipc1; atenolol
- Q&As
- Reviews
Q&As (10)
Ask a questionLike all medical treatments, ADRB1-targeted therapies may have potential risks and side effects. For example, beta-blockers, which target ADRB1 proteins, can cause problems such as low blood pressure, slowed heart rate, and bronchospasm in some patients. Additionally, genetic testing for ADRB1 variants may raise ethical and privacy concerns. It is important for patients to discuss the potential benefits and risks of any therapy with their healthcare provider and to undergo genetic testing only when it is medically appropriate and authorized.
Yes, there are numerous ongoing clinical trials involving ADRB1-targeted therapies for various medical conditions, including heart failure, hypertension, and cancer. These trials are evaluating the safety and efficacy of new drugs that target ADRB1 proteins or existing drugs in combination with other agents. Results from these trials may lead to new treatment options for patients and improved understanding of the role of ADRB1 signaling in these conditions.
In addition to heart disease and hypertension, ADRB1 has been implicated in other medical conditions such as asthma, diabetes, and obesity. Studies have suggested that genetic variations in the ADRB1 gene may play a role in the development or progression of these diseases. For example, some variants of ADRB1 have been linked to an increased risk of type 2 diabetes and impaired insulin sensitivity. Understanding the role of ADRB1 signaling in these conditions could lead to new therapeutic approaches.
ADRB1 receptors are primarily expressed in the heart and are involved in regulating cardiac contractility and heart rate. Activation of ADRB1 receptors by epinephrine or norepinephrine leads to an increase in intracellular cAMP levels, which ultimately activates protein kinase A (PKA) and calcium channels in cardiac myocytes. This leads to an increase in calcium influx into the cell, which results in increased contractility and heart rate.
Yes, variations in the ADRB1 gene can affect a person's response to drugs that target ADRB1 proteins, such as beta-blockers. For example, some studies have found that individuals with certain genetic variants of ADRB1 may have a reduced response to beta-blockers or an increased risk of side effects. Genetic testing may help identify individuals who are more likely to benefit from certain therapies or who may require a lower dose or alternative treatment.
ADRB1 research may help personalize medical treatment by identifying patients who are more likely to benefit from certain therapies or who may require alternative treatments based on their genetic and physiological factors. For example, some studies have suggested that genetic variations in ADRB1 may affect a person's response to beta-blockers or other ADRB1-targeted drugs, which can help guide treatment decisions. Additionally, taking into account a patient's individual ADRB1 signaling profile may help tailor treatment for optimal effectiveness and safety.
Several areas of research have shown promise in furthering our understanding of ADRB1 signaling and its role in disease. One area of focus is on the identification of new ligands or compounds that specifically target ADRB1 proteins. These compounds could potentially provide more selective and effective therapies for various medical conditions. Another area of interest is on understanding the mechanisms by which ADRB1 signaling regulates metabolic processes, such as glucose uptake and lipid metabolism.
ADRB1 receptors are expressed in many metabolic tissues, including the liver, adipose tissue, and skeletal muscle. Activation of ADRB1 receptors in these tissues stimulates the breakdown of stored fat, leading to increased release of free fatty acids and increased energy expenditure. In the liver, activation of ADRB1 receptors also stimulates glycogenolysis, leading to increased glucose release into the bloodstream.
Yes, lifestyle factors such as diet, physical activity, and stress can influence ADRB1 expression and signaling. For example, exercise has been shown to increase ADRB1 expression in skeletal muscle, which may contribute to the metabolic benefits of physical activity. Similarly, dietary factors such as caffeine and alcohol can affect ADRB1 signaling and may interact with drugs that target ADRB1 proteins. Understanding how lifestyle factors impact ADRB1 signaling may help optimize treatment strategies for various medical conditions.
Yes, research on ADRB1 signaling may provide insights into other G protein-coupled receptor (GPCR) signaling pathways, which are involved in numerous physiological processes. GPCR signaling is a complex network of interactions with various downstream effectors and signaling pathways. Studies of ADRB1 may help identify common or divergent features of GPCR signaling and may lead to the discovery of new therapeutic targets for a range of diseases.
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