Recombinant Human IRS1

• Cat.No.: IRS1-28643TH
• Product Overview: Recombinant fragment, corresponding to N terminal amino acids 1-355 of Human IRS1 with an N-terminal tag, 65kDa.

Specification

• Description: This gene encodes a protein which is phosphorylated by insulin receptor tyrosine kinase. Mutations in this gene are associated with type II diabetes and susceptibility to insulin resistance.
• Source: E. coli
• Form: Liquid
• Storage buffer: Preservative: NoneConstituents: 25% Glycerol, 50mM Sodium chloride, 50mM Tris HCl, 0.25mM DTT, 0.1mM PMSF, pH 7.5
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequence Similarities: Contains 1 IRS-type PTB domain.Contains 1 PH domain.

Gene Information

• Gene Name: IRS1 insulin receptor substrate 1 [ Homo sapiens ]
• Official Symbol: IRS1
• Synonyms: IRS1; insulin receptor substrate 1; HIRS 1
• Gene ID: 3667
• mRNA Refseq: NM_005544
• Protein Refseq: NP_005535
• Uniprot ID: P35568
• Chromosome Location: 2q36
• Pathway: Adipocytokine signaling pathway, organism-specific biosystem; Adipocytokine signaling pathway, conserved biosystem; Adipogenesis, organism-specific biosystem; Aldosterone-regulated sodium reabsorption, organism-specific biosystem; Aldosterone-regulated sodium reabsorption, conserved biosystem
• Function: SH2 domain binding; insulin receptor binding; insulin-like growth factor receptor binding; insulin-like growth factor-activated receptor activity; phosphatidylinositol 3-kinase binding