IRS1

IRS1 involved in several pathways and played different roles in them. We selected most pathways IRS1 participated on our site, such as cGMP-PKG signaling pathway, FoxO signaling pathway, mTOR signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IRS1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
cGMP-PKG signaling pathway	MYLK;PPP3CC;ATP2A1;PPP3CB;MEF2B;RGS2;GUCY1A3;CREB5;ATP2A3
FoxO signaling pathway	HOMER2;TGFB1A;PIK3CG;PTENB;KRAS;PIK3R3;CAT;CCNB1;G6PC3
mTOR signaling pathway	IKBKB;RPS6KA2;RPS6KA1;TSC1B;HIF1AB;TSC1;RRAGC;PIK3R5;RPS6KB2
PIK-Akt signaling pathway	ITGA5;LPAR6;ITGA9;PTK2;GNB3;ANGPT1;MAP2K1;FGF13;FGF21
AMPK signaling pathway	PRKAA2;G6PC3;SREBF1;PIK3R3;PFKFB1;CAMKK1;CREB5;SCD;PPP2R2A
Neurotrophin signaling pathway	NFKBIE;RAC1;NTRK1;PRKCD;NRAS;KRAS;PLCG2;RAP1B;SOS1
Insulin signaling pathway	PIK3R3A;FBP1A;PPP1R3DA;PRKACB;EIF4E2RS1;PCK1;ACACA;GSK3AA;INS2
Adipocytokine signaling pathway	TNFRSF1A;JAK2;PTPN11B;ADIPOR2;PRKAB1B;ACSL1;NFKB1;ACSL4A;ACSBG2
Regulation of lipolysis in adipocytes	PLIN1;NPY1R;TSHB;GNAS;PIK3CG;INS2;PIK3R2;NPY;AKT1
Type II diabetes mellitus	MAPK10;MAPK8;INS;SLC2A2;IKBKB;PIK3R1;PKM;PDX1;PKM2
Insulin resistance	PRKAG3B;FOXO1B;INSB;G6PC2;STAT3;G6PCA.1;PPARGC1A;IKBKB;PIK3R3B
Non-alcoholic fatty liver disease (NAFLD)	NDUFC2-KCTD14;NDUFS6;ATF4;NDUFB11;PIK3R5;ERN1;UQCRC1;PIK3CB;NFKB1
Aldosterone-regulated sodium reabsorption	HSD11B2;INS2;SCNN1B;PRKCB;ATP1B3;NR3C2;SCNN1G;INS1;NEDD4L
MicroRNAs in cancer	MDM4;TP63;ITGB3;PLAU;RDX;MET;SOS1;CDC25C;ABCC1

IRS1 has several biochemical functions, for example, SH2 domain binding, insulin receptor binding, insulin-like growth factor receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IRS1 itself. We selected most functions IRS1 had, and list some proteins which have the same functions with IRS1. You can find most of the proteins on our site.

Function	Related Protein
SH2 domain binding	DAG1;SRC;GNB2L1;MS4A2;SYP;NUP62;IRS1;INPPL1;SQSTM1
insulin receptor binding	DOK5;DOK1;DOK1B;SNX1;DOK6;SNX2;PIK3R1;DOK2;IGF1
insulin-like growth factor receptor binding	INSL4;SHC1;SOCS1;PIK3R1;IGF2A;IGF2B;Ren1;IRS1;IGF1
phosphatidylinositol 3-kinase binding	IRS1;CALM3;INSRA;CALM1;CALM2;FLT3;PIK3R1;IRS4;IGF1R
protein binding	CETN3;ZCCHC13;TRIM24;NUDT10;RBM3;PMM2;PAQR5;RAB3A;ZFYVE28
protein kinase C binding	HDAC7;HAND2;PARD6A;PRKCSH;DACT1;HSPB1;CASQ2;TOP2A;HINT1
signal transducer activity	CBLB;GPR184;MC5RB;MALT1;SLC44A2;TAAR8A;TAS2R114;STAT5A;TAAR10A
transmembrane receptor protein tyrosine kinase adaptor activity	GAB2;IRS1;SH2B2;DOK2;SHC1;FRS2;TRAT1;PIK3R1;BLNK

IRS1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IRS1 here. Most of them are supplied by our site. Hope this information will be useful for your research of IRS1.

PIK3R1; PIK3CA

Gene Family

TGF

Research Area

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