• Official Full Name

    insulin receptor substrate 1

  • Overview

    This gene encodes a protein which is phosphorylated by insulin receptor tyrosine kinase. Mutations in this gene are associated with type II diabetes and susceptibility to insulin resistance. [provided by RefSeq, Nov 2009]
  • Synonyms

    IRS1; insulin receptor substrate 1; HIRS-1; IRS-1;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • HEK293T
  • Mamanlian cells
  • Mammalian Cell
  • Sf9 Insect Cell
  • C
  • His
  • Flag
  • GST
  • His (Fc)
  • Avi
  • His|T7
  • Myc|DDK
  • N/A
  • N
  • MBP
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human IRS1-1466H Recombinant Human Insulin Receptor Substrate 1, GST-tagged Sf9 Insect Cell GST
Human IRS1-12HCL Recombinant Human IRS1 HEK293T cell lysate HEK293T Myc/DDK
Human IRS1-1467H Recombinant Human Insulin Receptor Substrate 1, GST-tagged E.coli GST
Human IRS1-28643TH Recombinant Human IRS1 E.coli N/A
Human IRS1-28726TH Recombinant Human IRS1 N/A
Human IRS1-872HCL Recombinant Human IRS1 cell lysate N/A
Human IRS1-8560HFL Recombinant Full Length Human IRS1, Flag-tagged Mamanlian cells Flag
Human IRS1-2338H Recombinant Human IRS1 Protein, His-tagged E.coli N-His Asp12-Phe264
Human IRS1-3380H Recombinant Human IRS1 Protein (Pro4-Arg267), N-His tagged E.coli N-His Pro4-Arg267
Human IRS1-2738H Recombinant Human IRS1 protein(831-900 aa), C-His-tagged E.coli C-His 831-900 aa
Human IRS1-4543H Recombinant Human IRS1 protein, MBP&His-Avi-tagged, Biotinylated E.coli N-MBP&C-His-Avi 157-267aa
Mouse Irs1-7871M Recombinant Mouse Irs1 protein, His & T7-tagged E.coli His/T7 Pro837~Gln1089 (Accession # P35569)
Mouse IRS1-8313M Recombinant Mouse IRS1 Protein Mammalian Cell His
Mouse IRS1-4610M Recombinant Mouse IRS1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse IRS1-4610M-B Recombinant Mouse IRS1 Protein Pre-coupled Magnetic Beads HEK293
Rat IRS1-3099R Recombinant Rat IRS1 Protein Mammalian Cell His
Rat IRS1-2755R Recombinant Rat IRS1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat IRS1-2755R-B Recombinant Rat IRS1 Protein Pre-coupled Magnetic Beads HEK293
Chicken IRS1-3212C Recombinant Chicken IRS1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource
  • IRS1 Related Signal Pathway

IRS1 involved in several pathways and played different roles in them. We selected most pathways IRS1 participated on our site, such as cGMP-PKG signaling pathway, FoxO signaling pathway, mTOR signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IRS1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
PIK-Akt signaling pathwayFGF4;PIK3CA;IFNB1;PPP2R5C;IFNA14;CCNE2;PIK3R2;PPP2CB;Pdgfa&Pdgfb
Neurotrophin signaling pathwayCALML3;GRB2;FASLG;PIK3CG;ZNF274;ARHGDIA;PIK3CA;NGF;GAB1
Insulin signaling pathwayRPTOR;ARAF;LIPE;FOXO1A;SHC4;RPS6KB1;MKNK1;PTPN1;FBP1
Adipocytokine signaling pathwayPRKAG2;SOCS3B;ACSL5;SOCS3;CAMKK1A;NFKBIAB;LEP;SLC2A1;PRKAB2
Regulation of lipolysis in adipocytesPRKACA;FABP4;PIK3CD;PTGER3;LIPE;PIK3R1;NPY;PIK3CB;PIK3R3
Type II diabetes mellitusTNF;HK1;MAFA;SOCS1;IRS2;PIK3R1;MAPK1;IRS1;HKDC1
Non-alcoholic fatty liver disease (NAFLD)UQCRQ;INSR;NR1H3;COX7A2;SDHA;NDUFB8;COX6A2;NDUFS2;NDUFV3
Aldosterone-regulated sodium reabsorptionALPHA-ENAC;HSD11B2;INS;PRKCB;SCNN1G;SFN;PIK3R3;PIK3CD;INS2

IRS1 has several biochemical functions, for example, SH2 domain binding, insulin receptor binding, insulin-like growth factor receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IRS1 itself. We selected most functions IRS1 had, and list some proteins which have the same functions with IRS1. You can find most of the proteins on our site.

Function Related Protein
insulin receptor bindingDOK5;ENPP1;SHC1;IGF1;IGF2;IGF1R;PHIP;INS2;INS
insulin-like growth factor receptor bindingINS2;REN;YWHAH;INSR;IRS1;Ren1;IGF2;INS;SOCS1
phosphatidylinositol 3-kinase bindingINSR;IRS1;FYN;INSRR;PIK3R1;PDGFRB;CALM1;TYRO3;IGF1R
protein kinase C bindingGNB2L1;PKP2;HSPB1;HINT1;YWHAG;TWF2;TRPV4;HDAC7;PICK1
signal transducer activityFPR-RS3;GNAL;GNAV1;MRGPRB1;IL13RA2;GNGT2A;BAI2;TAAR8B;OLFR474
transmembrane receptor protein tyrosine kinase adaptor activitySH2B2;FRS2;DOK2;PIK3R1;STAP1;GAB2;TRAT1;IRS1;SHC1

IRS1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IRS1 here. Most of them are supplied by our site. Hope this information will be useful for your research of IRS1.


Gene Family


Research Area

Related articles

Kim, MJ; Rangasamy, S; et al. Cell lysis-free quantum dot multicolor cellular imaging-based mechanism study for TNF-alpha-induced insulin resistance. JOURNAL OF NANOBIOTECHNOLOGY 13:-(2015).
Kitazawa, T; Yoshino, Y; et al. Lopinavir inhibits insulin signaling by promoting protein tyrosine phosphatase 1B expression. EXPERIMENTAL AND THERAPEUTIC MEDICINE 8:851-855(2014).
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