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Official Full Name insulin receptor substrate 1
Background This gene encodes a protein which is phosphorylated by insulin receptor tyrosine kinase. Mutations in this gene are associated with type II diabetes and susceptibility to insulin resistance. [provided by RefSeq, Nov 2009]
Synonyms IRS1; insulin receptor substrate 1; HIRS-1; IRS-1;
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Source :
    • E.coli
    • HEK293T
    • Mammalian Cell
    • Sf9 Insect Cell
    • Tag :
    • GST
    • His
    • T7
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human IRS1-12HCL Recombinant Human IRS1 HEK293T cell lysate HEK293T Myc/DDK
    Human IRS1-1466H Recombinant Human Insulin Receptor Substrate 1, GST-tagged Sf9 Insect Cell GST
    Human IRS1-1467H Recombinant Human Insulin Receptor Substrate 1, GST-tagged E.coli GST
    Human IRS1-28643TH Recombinant Human IRS1 E.coli N/A
    Human IRS1-28726TH Recombinant Human IRS1 N/A
    Human IRS1-872HCL Recombinant Human IRS1 cell lysate N/A
    Mouse Irs1-7871M Recombinant Mouse Irs1 protein, His & T7-tagged E.coli His/T7
    Mouse IRS1-8313M Recombinant Mouse IRS1 Protein Mammalian Cell His
    Rat IRS1-3099R Recombinant Rat IRS1 Protein Mammalian Cell His
    Chicken IRS1-3212C Recombinant Chicken IRS1 Mammalian Cell His

    irs1 involved in several pathways and played different roles in them. We selected most pathways irs1 participated on our site, such as cGMP-PKG signaling pathway, FoxO signaling pathway, mTOR signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with irs1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    cGMP-PKG signaling pathway ATP1A1; CREB3L2; PIK3R2; SLC25A31; NFATC2; ATP2A1; CREB3L1; MAPK1; ATP1B4; PDE3B
    FoxO signaling pathway USP7; FOXO1; PIK3CA; GRB2B; KLF2B; MAP2K2A; AKT2L; MAPK8B; SMAD2; SLC2A4
    mTOR signaling pathway AKT1; PIK3R5; PIK3R3B; VEGFAB; RB1CC1; PIK3R2; PRKCG; RPS6KB2; RPS6KA1; PDPK1B
    PIK-Akt signaling pathway PDGFA; KLK1B4; TCL1A; IFNA17; GHR; PIK3R5; RXRA; AKT1; FGF9; GNG11
    AMPK signaling pathway IGF1; CRTC2; CREB3L1; FBP2; PCK2; Scd1; CCNA2; TSC2; PPP2R1A; INS2
    Neurotrophin signaling pathway BAX; KIDINS220; CALM4; TP53; PIK3R5; NGF; PIK3CG; CDC42; PIK3CD; MAP2K7
    Insulin signaling pathway PHKA1; MKNK2A; ACACA; PPP1CA; TRIP10A; MAPK8; SOCS9; TSC2; G6PC; FLOT2A
    Adipocytokine signaling pathway RXRBA; ADIPOQB; RXRB; IRS4; RXRAA; ACSL4; IKBKB; PRKAG1; ADIPOR2; TRAF2
    Regulation of lipolysis in adipocytes GNAI3; PTGER3; PRKACB; PDE3B; LIPE; INSR; PRKG2; Adcy4; PLIN1; TSHB
    Type II diabetes mellitus HK2; MAPK10; IRS4; PIK3R2; INS-IGF2; IKBKB; PRKCZ; PIK3CB; PKLR; PRKCE
    Insulin resistance PTPN11; PTPN1; NOS3; MAPK9; RPS6KA3B; PRKCZ; MTOR; PTPRF; PRKAA2; PRKCDA
    Non-alcoholic fatty liver disease (NAFLD) RELA; BAX; PRKAB1; XBP1; NDUFB11; INS2; NFKB1; PRKAG3; NDUFA5; NDUFV2
    Aldosterone-regulated sodium reabsorption INS1; SFN; ATP1A2; MAPK3; IGF1; SLC9A3R2; FXYD2; PIK3CG; PIK3CA; ATP1B4
    MicroRNAs in cancer GLS; RAF1; ABCC1; PDCD4; MDM2; ITGA5; MMP9; SHC1; ERBB3; TRP63

    irs1 has several biochemical functions, for example, SH2 domain binding, insulin receptor binding, insulin-like growth factor receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by irs1 itself. We selected most functions irs1 had, and list some proteins which have the same functions with irs1. You can find most of the proteins on our site.

    Function Related Protein
    SH2 domain binding CRK; SH3PXD2B; NUP62; AFAP1L2; CTR9; LILRB1; NLK; LAX1; SKAP1; GNB2L1
    insulin receptor binding IRS1; SNX1; IGF2; PIK3R1; DOK5; FRS2A; PTPN1; DOK3; FRS3; SLC2A2
    insulin-like growth factor receptor binding Ren1; INSL4; IRS1; ARRB1; INS; IGF2B; INSR; YWHAG; SOCS2; IGF3
    phosphatidylinositol 3-kinase binding IGF1R; INSRA; JAK2; CALM1; HCST; CALM3; IRS4; BECN1; DAB1; FLT3
    protein binding CHCHD6; YIPF2; PEX11A; ARHGEF7; ZMYND10; NIPSNAP1; NOP56; SLC6A20; TRIM74; RAB34
    protein kinase C binding HDAC7; PAWR; TRPV4; HDAC5; ADD3; DACT1; UGT1A7; C1QBP; ADAM9; DACT3
    signal transducer activity TAAR14L; NPY8BR; GPR34A; TAAR6; NFKBIB; IKBKG; V2RX1; OLFCG1; GHRHRL; MRGPRB3
    transmembrane receptor protein tyrosine kinase adaptor activity PIK3R1; STAP1; SH2B2; IRS1; SHC1; DOK2; TRAT1; GAB2; FRS2; BLNK

    irs1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with irs1 here. Most of them are supplied by our site. Hope this information will be useful for your research of irs1.

    PIK3R1; PIK3CA

    Kim, MJ; Rangasamy, S; et al. Cell lysis-free quantum dot multicolor cellular imaging-based mechanism study for TNF-alpha-induced insulin resistance. JOURNAL OF NANOBIOTECHNOLOGY 13:-(2015).
    Kitazawa, T; Yoshino, Y; et al. Lopinavir inhibits insulin signaling by promoting protein tyrosine phosphatase 1B expression. EXPERIMENTAL AND THERAPEUTIC MEDICINE 8:851-855(2014).


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