IRS1

  • Official Full Name

    insulin receptor substrate 1

  • Overview

    This gene encodes a protein which is phosphorylated by insulin receptor tyrosine kinase. Mutations in this gene are associated with type II diabetes and susceptibility to insulin resistance. [provided by RefSeq, Nov 2009]
  • Synonyms

    IRS1; insulin receptor substrate 1; HIRS-1; IRS-1;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • HEK293T
  • Mamanlian cells
  • Mammalian Cell
  • Sf9 Insect Cell
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • His|T7
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human IRS1-1466H Recombinant Human Insulin Receptor Substrate 1, GST-tagged Sf9 Insect Cell GST
Human IRS1-12HCL Recombinant Human IRS1 HEK293T cell lysate HEK293T Myc/DDK
Human IRS1-1467H Recombinant Human Insulin Receptor Substrate 1, GST-tagged E.coli GST
Human IRS1-28643TH Recombinant Human IRS1 E.coli N/A
Human IRS1-28726TH Recombinant Human IRS1 N/A
Human IRS1-872HCL Recombinant Human IRS1 cell lysate N/A
Human IRS1-8560HFL Recombinant Full Length Human IRS1, Flag-tagged Mamanlian cells Flag
Human IRS1-2338H Recombinant Human IRS1 Protein, His-tagged E.coli N-His
Human IRS1-3380H Recombinant Human IRS1 Protein (Pro4-Arg267), N-His tagged E.coli N-His
Mouse Irs1-7871M Recombinant Mouse Irs1 protein, His & T7-tagged E.coli His/T7
Mouse IRS1-8313M Recombinant Mouse IRS1 Protein Mammalian Cell His
Mouse IRS1-4610M Recombinant Mouse IRS1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse IRS1-4610M-B Recombinant Mouse IRS1 Protein Pre-coupled Magnetic Beads HEK293
Rat IRS1-3099R Recombinant Rat IRS1 Protein Mammalian Cell His
Rat IRS1-2755R Recombinant Rat IRS1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat IRS1-2755R-B Recombinant Rat IRS1 Protein Pre-coupled Magnetic Beads HEK293
Chicken IRS1-3212C Recombinant Chicken IRS1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • IRS1 Related Articles
  • IRS1 Related Gene Family
  • IRS1 Related Research Area
  • IRS1 Related Signal Pathway

IRS1 involved in several pathways and played different roles in them. We selected most pathways IRS1 participated on our site, such as cGMP-PKG signaling pathway, FoxO signaling pathway, mTOR signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IRS1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
cGMP-PKG signaling pathwayKCNMB3;BNP;PIK3R2;IRS2;INSR;MEF2D;PLCB4;MAPK1;PDE5A
FoxO signaling pathwayNLK;NLK2;MAPK14B;RAG2;PIK3R5;PIK3R3A;PLK2;CCND2A;MAPK12A
mTOR signaling pathwayIRS1;PRKCB;INS2;RPTOR;PIK3R1;PIK3CA;AKT2L;INSB;RB1CC1
PIK-Akt signaling pathwayGNGT2;GNG8;Itga10&Itgb1;RXRA;PPP2R2A;CCND2;AKT1;ANGPT1;PPP2R1A
AMPK signaling pathwayTSC2;RAB11B;MAP3K7;PFKP;SCD;SREBF1;IGF1;ACACA;CREB3L4
Neurotrophin signaling pathwayMAPK3;MATK;MAP3K5;PIK3CA;ABL1;AKT1;BAD;ARHGDIG;TP73
Insulin signaling pathwayHRAS;PYGL;CALM2A;PIK3R5;PIK3R3;MKNK2A;FOXO1A;RPS6KB1B;PCK1
Adipocytokine signaling pathwayAKT2;PRKAG1;NPY;PTPN11A;ACSL3A;ACSL5;NFKBIAA;G6PCA.2;IRS1
Regulation of lipolysis in adipocytesGNAI1;PLIN1;PIK3CD;PIK3CG;AKT1;PRKACA;PDE3B;PIK3R5;GNAS
Type II diabetes mellitusPKM2;SOCS3;SOCS4;INS-IGF2;MAPK3;MAPK10;PDX1;IRS1;INS1
Insulin resistancePRKCE;PYGB;PPP1CC;IL6;INSR;PYGM;PRKCB;SLC27A1A;NOS3
Non-alcoholic fatty liver disease (NAFLD)TNF;BAX;EIF2AK3;CDC42;SREBF1;IL-8;MAP3K11;COX7B2;FAS
Aldosterone-regulated sodium reabsorptionMAPK1;NR3C2;INS1;SCNN1G;ATP1A1;SFN;PIK3CA;PIK3R5;KCNJ1
MicroRNAs in cancerPIK3R2;MCL1;ABL1;TGFB2;STAT3;RAF1;TP63;ST14;PRKCB

IRS1 has several biochemical functions, for example, SH2 domain binding, insulin receptor binding, insulin-like growth factor receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IRS1 itself. We selected most functions IRS1 had, and list some proteins which have the same functions with IRS1. You can find most of the proteins on our site.

Function Related Protein
SH2 domain bindingPAG1;TRPV4;PTK2;CTR9;GNB2L1;AFAP1L2;SHCBP1;LAX1;SRC
insulin receptor bindingINSL3;PTPN11;GRB10;PIK3R1;DOK4;PTPN1;IRS4;DOK6;IGF2
insulin-like growth factor receptor bindingPIK3R1;SHC1;IGF2A;IRS1;IGF2B;INS2;IGF1;IGF3;IGF2
phosphatidylinositol 3-kinase bindingFYN;IRS2;FLT3;IGF1RA;CALM3;ATP1A1;BECN1;PIK3R1;INSRR
protein bindingGLA;GALR2;RPGRIP1;DDX3X;BSG;UBA5;RCN3;ARHGEF2;CALML3
protein kinase C bindingAVPR1B;IRS1;C1QBP;UGT1A7;PARD3;GLRX3;HAND2;TDG;ADAM9
signal transducer activityPTGER1C;GNG10;TRAF2;TAS2R143;RGS9B;GNA11B;OLFR181;DKKL1;FLNA
transmembrane receptor protein tyrosine kinase adaptor activityFRS2;SHC1;DOK2;PIK3R1;STAP1;SH2B2;BLNK;GAB2;TRAT1

IRS1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IRS1 here. Most of them are supplied by our site. Hope this information will be useful for your research of IRS1.

PIK3R1; PIK3CA

Kim, MJ; Rangasamy, S; et al. Cell lysis-free quantum dot multicolor cellular imaging-based mechanism study for TNF-alpha-induced insulin resistance. JOURNAL OF NANOBIOTECHNOLOGY 13:-(2015).
Kitazawa, T; Yoshino, Y; et al. Lopinavir inhibits insulin signaling by promoting protein tyrosine phosphatase 1B expression. EXPERIMENTAL AND THERAPEUTIC MEDICINE 8:851-855(2014).
TGF
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