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IRS1

Official Full Name

insulin receptor substrate 1
Overview

This gene encodes a protein which is phosphorylated by insulin receptor tyrosine kinase. Mutations in this gene are associated with type II diabetes and susceptibility to insulin resistance. [provided by RefSeq, Nov 2009]
Synonyms

IRS1; insulin receptor substrate 1; HIRS-1; IRS-1;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Mouse
Rat

Source

E.coli
HEK293
HEK293T
Mamanlian cells
Mammalian Cell
Sf9 Insect Cell

Tag

C
His
Flag
GST
His (Fc)
Avi
His|T7
Myc|DDK
N/A
N
MBP

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	IRS1-1466H	Recombinant Human Insulin Receptor Substrate 1, GST-tagged	Sf9 Insect Cell	GST		Inquiry
Human	IRS1-12HCL	Recombinant Human IRS1 HEK293T cell lysate	HEK293T	Myc/DDK		Inquiry
Human	IRS1-1467H	Recombinant Human Insulin Receptor Substrate 1, GST-tagged	E.coli	GST		Inquiry
Human	IRS1-28643TH	Recombinant Human IRS1	E.coli	N/A		Inquiry
Human	IRS1-28726TH	Recombinant Human IRS1		N/A		Inquiry
Human	IRS1-872HCL	Recombinant Human IRS1 cell lysate		N/A		Inquiry
Human	IRS1-8560HFL	Recombinant Full Length Human IRS1, Flag-tagged	Mamanlian cells	Flag		Inquiry
Human	IRS1-2338H	Recombinant Human IRS1 Protein, His-tagged	E.coli	N-His	Asp12-Phe264	Inquiry
Human	IRS1-3380H	Recombinant Human IRS1 Protein (Pro4-Arg267), N-His tagged	E.coli	N-His	Pro4-Arg267	Inquiry
Human	IRS1-2738H	Recombinant Human IRS1 protein(831-900 aa), C-His-tagged	E.coli	C-His	831-900 aa	Inquiry
Human	IRS1-4543H	Recombinant Human IRS1 protein, MBP&His-Avi-tagged, Biotinylated	E.coli	N-MBP&C-His-Avi	157-267aa	Inquiry
Mouse	Irs1-7871M	Recombinant Mouse Irs1 protein, His & T7-tagged	E.coli	His/T7	Pro837~Gln1089 (Accession # P35569)	Inquiry
Mouse	IRS1-8313M	Recombinant Mouse IRS1 Protein	Mammalian Cell	His		Inquiry
Mouse	IRS1-4610M	Recombinant Mouse IRS1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	IRS1-4610M-B	Recombinant Mouse IRS1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rat	IRS1-3099R	Recombinant Rat IRS1 Protein	Mammalian Cell	His		Inquiry
Rat	IRS1-2755R	Recombinant Rat IRS1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rat	IRS1-2755R-B	Recombinant Rat IRS1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Chicken	IRS1-3212C	Recombinant Chicken IRS1	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
Other Resource
IRS1 Related Signal Pathway

IRS1 involved in several pathways and played different roles in them. We selected most pathways IRS1 participated on our site, such as cGMP-PKG signaling pathway, FoxO signaling pathway, mTOR signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IRS1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
cGMP-PKG signaling pathway	MAP2K1;SLC8A1;NFATC1;PPP3CC;CALM1;NPR1;PIK3R2;GNAI2;PLCB4
FoxO signaling pathway	FOXG1A;HRASB;BNIP4;SETD7;KRAS;STK11;FOXO1B;Fasl;EGFRA
mTOR signaling pathway	TNF;STRADA;RPS6KAL;AKT2;EIF4EA;INS;PTEN;EIF4E1B;RPS6
PIK-Akt signaling pathway	FGF4;PIK3CA;IFNB1;PPP2R5C;IFNA14;CCNE2;PIK3R2;PPP2CB;Pdgfa&Pdgfb
AMPK signaling pathway	GYS1;INS1;PIK3R3;IRS2;PRKAA1;RPTOR;AKT3;RHEB;CAMKK2
Neurotrophin signaling pathway	CALML3;GRB2;FASLG;PIK3CG;ZNF274;ARHGDIA;PIK3CA;NGF;GAB1
Insulin signaling pathway	RPTOR;ARAF;LIPE;FOXO1A;SHC4;RPS6KB1;MKNK1;PTPN1;FBP1
Adipocytokine signaling pathway	PRKAG2;SOCS3B;ACSL5;SOCS3;CAMKK1A;NFKBIAB;LEP;SLC2A1;PRKAB2
Regulation of lipolysis in adipocytes	PRKACA;FABP4;PIK3CD;PTGER3;LIPE;PIK3R1;NPY;PIK3CB;PIK3R3
Type II diabetes mellitus	TNF;HK1;MAFA;SOCS1;IRS2;PIK3R1;MAPK1;IRS1;HKDC1
Insulin resistance	PRKAG2A;ACACB;GSK3AA;SLC27A1B;PRKAG2;SLC27A3;IRS1;PCK2;PRKAB1A
Non-alcoholic fatty liver disease (NAFLD)	UQCRQ;INSR;NR1H3;COX7A2;SDHA;NDUFB8;COX6A2;NDUFS2;NDUFV3
Aldosterone-regulated sodium reabsorption	ALPHA-ENAC;HSD11B2;INS;PRKCB;SCNN1G;SFN;PIK3R3;PIK3CD;INS2
MicroRNAs in cancer	NOTCH2;MAPK7;ROCK1;IRS1;EZH2;SERPINB5;NFKB1;NOTCH4;HNRNPK

IRS1 has several biochemical functions, for example, SH2 domain binding, insulin receptor binding, insulin-like growth factor receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IRS1 itself. We selected most functions IRS1 had, and list some proteins which have the same functions with IRS1. You can find most of the proteins on our site.

Function	Related Protein
SH2 domain binding	DAG1;PAG1;DLC1;SYNGR3;LILRB1;LCK;SYP;LAT2;JAK2
insulin receptor binding	DOK5;ENPP1;SHC1;IGF1;IGF2;IGF1R;PHIP;INS2;INS
insulin-like growth factor receptor binding	INS2;REN;YWHAH;INSR;IRS1;Ren1;IGF2;INS;SOCS1
phosphatidylinositol 3-kinase binding	INSR;IRS1;FYN;INSRR;PIK3R1;PDGFRB;CALM1;TYRO3;IGF1R
protein binding	KHDRBS1;MACROD1;LRRC29;DOLK;TUBA3E;FAM113A;CUL4B;MBL2;SUMO2
protein kinase C binding	GNB2L1;PKP2;HSPB1;HINT1;YWHAG;TWF2;TRPV4;HDAC7;PICK1
signal transducer activity	FPR-RS3;GNAL;GNAV1;MRGPRB1;IL13RA2;GNGT2A;BAI2;TAAR8B;OLFR474
transmembrane receptor protein tyrosine kinase adaptor activity	SH2B2;FRS2;DOK2;PIK3R1;STAP1;GAB2;TRAT1;IRS1;SHC1

IRS1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IRS1 here. Most of them are supplied by our site. Hope this information will be useful for your research of IRS1.

PIK3R1; PIK3CA

Gene Family

Research Area

Endocrine Regulation of Lipid Metabolism

phospho-Serine/phospho-Threonine Binding Proteins

Kim, MJ; Rangasamy, S; et al. Cell lysis-free quantum dot multicolor cellular imaging-based mechanism study for TNF-alpha-induced insulin resistance. JOURNAL OF NANOBIOTECHNOLOGY 13:-(2015).

Kitazawa, T; Yoshino, Y; et al. Lopinavir inhibits insulin signaling by promoting protein tyrosine phosphatase 1B expression. EXPERIMENTAL AND THERAPEUTIC MEDICINE 8:851-855(2014).