IRS1

IRS1 involved in several pathways and played different roles in them. We selected most pathways IRS1 participated on our site, such as cGMP-PKG signaling pathway, FoxO signaling pathway, mTOR signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IRS1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
cGMP-PKG signaling pathway	PPP3CC;PPP1R12A;PIK3CB;MEF2D;AGTR1B;ATP1A1;CALML3;BDKRB2;SRF
FoxO signaling pathway	INSR;AKT2L;MAPK14A;KLF2A;PRKAB1;MAP2K2;MAPK12A;TGFBR2;INS2
mTOR signaling pathway	EIF4EA;POLDIP3;RRAGC;RB1CC1;VEGFAA;VEGFAB;PRKCB;RPS6KA1;RPS6KA3
PIK-Akt signaling pathway	PPP2R5A;PPP2R5D;PPP2R2D;PPP2CB;GYS1;GNG10;PIK3CD;CREB3L2;HSP90AA1
AMPK signaling pathway	INS1;PRKAG1;RPS6KB2;CRTC2;RAB10;PPP2R5C;PFKFB3;STRADA;CREB5
Neurotrophin signaling pathway	NTRK1;PIK3R3;RPS6KA1;MAPK3;RPS6KA3;RPS6KA2;YWHAE;MAP2K2;SHC4
Insulin signaling pathway	FBP2;EIF4E2;FLOT1A;SOCS9;PIK3R3B;RPS6KB1B;PRKCI;AKT1;PRKAR2AA
Adipocytokine signaling pathway	ADIPOR2;ADIPOR1;CD36;PTPN11;G6PC2;ADIPOQB;POMCA;ACSL4A;MAPK9
Regulation of lipolysis in adipocytes	LOC100328615;GNAI3;AKT1;NPY1R;IRS4;PRKG1;PRKACA;NPR1;PIK3CD
Type II diabetes mellitus	MAPK8;IRS4;CACNA1G;SOCS2;ADIPOQ;MAPK1;SOCS3;PIK3R3;PIK3CD
Insulin resistance	PRKAA1;PIK3R3A;INS2;PTENA;PRKCQ;MLXIPL;INSR;AKT1;MAPK8
Non-alcoholic fatty liver disease (NAFLD)	NDUFA2;ERN1;Fasl;PIK3CG;NDUFB7;NDUFA7;PRKAG2;NDUFC2-KCTD14;PIK3R3
Aldosterone-regulated sodium reabsorption	MAPK1;INS1;PIK3CA;IGF1;PIK3R1;ATP1B1;PIK3R5;FXYD2;PRKCG
MicroRNAs in cancer	FOXP1;TP63;STAT3;BCL2L2;MMP9;HDAC1;MAPK7;PTEN;SLC7A1

IRS1 has several biochemical functions, for example, SH2 domain binding, insulin receptor binding, insulin-like growth factor receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IRS1 itself. We selected most functions IRS1 had, and list some proteins which have the same functions with IRS1. You can find most of the proteins on our site.

Function	Related Protein
SH2 domain binding	NUP62;SH3PXD2B;LILRB1;DAG1;SYNGR3;MS4A2;SQSTM1;NLK;TRPV4
insulin receptor binding	FRS2A;DOK3;IRS1;DOK7;DOK4;DOK1;PDPK1;PTPN1;SNX1
insulin-like growth factor receptor binding	IGF2A;YWHAG;SOCS2;ARRB1;INS;IGF1;INSR;GNAS;PIK3R1
phosphatidylinositol 3-kinase binding	CALM1;PDGFRB;TYRO3;IRS2;JAK2;HCST;IRS4;CALM2;INSRB
protein binding	KRTAP3-1;MGRN1;NKX2;ITGB3;C16orf72;NETO2;RNF40;RERG;FAM20C
protein kinase C binding	GRK5;GLRX3;SDPRA;YWHAG;ADD3;C1QBP;PRKCB;HDAC7A;HDAC9
signal transducer activity	FKBP1A;OLFCG3;ZDHHC13;GNG12;GNA13B;O3far1;PLCD3A;OPN4A;TMTOPS3A
transmembrane receptor protein tyrosine kinase adaptor activity	IRS1;DOK2;FRS2;STAP1;GAB2;SH2B2;TRAT1;PIK3R1;SHC1

IRS1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IRS1 here. Most of them are supplied by our site. Hope this information will be useful for your research of IRS1.

PIK3R1; PIK3CA

Gene Family

TGF

Research Area

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