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IRS4

Official Full Name

Insulin receptor substrate 4
Overview

IRS4 encodes the insulin receptor substrate 4, a cytoplasmic protein that contains many potential tyrosine and serine/threonine phosphorylation sites. Tyrosine-phosphorylated IRS4 protein has been shown to associate with cytoplasmic signalling molecules that contain SH2 domains. The IRS4 protein is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation.
Synonyms

IRS4; nsulin receptor substrate 4; pp160; phosphoprotein of 160 kDa; 160 kDa phosphotyrosine protein; IRS-4; PY160;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse

Source

E.coli
HEK293
Mammalian Cell
Wheat Germ

Tag

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	IRS4-1052H	Recombinant Human IRS4 protein, His & T7-tagged	E.coli	His&T7	Met1~Arg196 (Accession # O14654)	Inquiry
Human	IRS4-5157HCL	Recombinant Human IRS4 293 Cell Lysate	HEK293	Non		Inquiry
Human	IRS4-5028H	Recombinant Human IRS4 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Mouse	IRS4-8316M	Recombinant Mouse IRS4 Protein	Mammalian Cell	His		Inquiry
Mouse	Irs4-1053M	Recombinant Mouse Irs4 protein, His & T7-tagged	E.coli	His&T7	Met1~Arg299 (Accession # Q9Z0Y7)	Inquiry
Mouse	IRS4-4612M-B	Recombinant Mouse IRS4 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	IRS4-4612M	Recombinant Mouse IRS4 Protein, His (Fc)-Avi-tagged	HEK293	His&Fc&Avi		Inquiry

Involved Pathway
Protein Function
Interacting Protein

IRS4 involved in several pathways and played different roles in them. We selected most pathways IRS4 participated on our site, such as cGMP-PKG signaling pathway, FoxO signaling pathway, AMPK signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IRS4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
cGMP-PKG signaling pathway	ITPR3;LOC100328615;CALM1;CALML3;MEF2D;RGS2;MYLK3;IRS4;IRS1
FoxO signaling pathway	NLK1;PLK2B;HRASA;PRKAG3B;STAT3;BNIP4;MAPK14A;AKT2L;G6PC
AMPK signaling pathway	CREB1;ULK1;Scd2;PRKAB1;PRKAG1;PFKFB2;PIK3CA;PPARG;PDPK1
Insulin signaling pathway	PIK3CG;PRKACG;INS;PRKAG3B;SHC4;EXOC7;PRKAR2B;MAPK8;MTOR
Adipocytokine signaling pathway	PRKAG3B;ACSL3A;TRADD;G6PCA.2;PRKCQ;ADIPOR1;ACSL1;LEPR;IKBKB
Regulation of lipolysis in adipocytes	PRKACA;PLIN1;AQP7;PTGER3;NPR1;INS2;AKT2;AKT1;PNPLA2
Type II diabetes mellitus	PRKCZ;HK2;SOCS1;PIK3R1;SLC2A2;MTOR;MAPK3;HK3;PIK3CA

IRS4 has several biochemical functions, for example, SH3/SH2 adaptor activity, insulin receptor binding, phosphatidylinositol 3-kinase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IRS4 itself. We selected most functions IRS4 had, and list some proteins which have the same functions with IRS4. You can find most of the proteins on our site.

Function	Related Protein
SH3/SH2 adaptor activity	SH3BGR;GRB10;SH2D2A;ARHGAP4;SKAP2;GRB14;SLA2;SKAP1;CRKL
insulin receptor binding	SHC1;DOK4;PIK3R1;DOK1;FRS2;IGF2;SNX1;DOK6;INS2
phosphatidylinositol 3-kinase binding	IGF1R;INSRB;IRS1;BECN1;INSRR;PIK3R1;HCST;CALM3;INSR
protein binding	PAGE5;CNIH2;HPS6;EP300;C1orf116;NUBP2;FIP1L1;TXNRD1;ETS2
signal transducer activity	GNAO1A;ZDHHC17;IL13RA2;PLCD1A;UNC13B;GPR30;OLFR8;ADORA2AB;TAAR10C

IRS4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IRS4 here. Most of them are supplied by our site. Hope this information will be useful for your research of IRS4.

YWHAB; P; PTGES3; CRK; PPP2R2B; EGFR; ERBB2