IRS4

  • Official Full Name

    Insulin receptor substrate 4

  • Overview

    IRS4 encodes the insulin receptor substrate 4, a cytoplasmic protein that contains many potential tyrosine and serine/threonine phosphorylation sites. Tyrosine-phosphorylated IRS4 protein has been shown to associate with cytoplasmic signalling molecules that contain SH2 domains. The IRS4 protein is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation.

  • Synonyms

    IRS4;nsulin receptor substrate 4;pp160;phosphoprotein of 160 kDa;160 kDa phosphotyrosine protein;IRS-4;PY160

Recombinant Proteins

  • Human
  • Mouse
  • E.coli
  • Mammalian Cells
  • HEK293
  • Wheat Germ
  • His
  • T7
  • Non
  • Avi
  • Fc
  • GST
Cat.# Product name Source (Host) Species Tag Protein Length Price
IRS4-1052H Recombinant Human IRS4 protein, His & T7-tagged E.coli Human His&T7 Met1~Arg196
Irs4-1053M Recombinant Mouse Irs4 protein, His & T7-tagged E.coli Mouse His&T7 Met1~Arg299
IRS4-8316M Recombinant Mouse IRS4 Protein Mammalian Cells Mouse His
IRS4-5157HCL Recombinant Human IRS4 293 Cell Lysate HEK293 Human Non
IRS4-4612M Recombinant Mouse IRS4 Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
IRS4-4612M-B Recombinant Mouse IRS4 Protein Pre-coupled Magnetic Beads HEK293 Mouse
IRS4-5028H Recombinant Human IRS4 Protein, GST-tagged Wheat Germ Human GST

    Involved Pathway

    IRS4 involved in several pathways and played different roles in them. We selected most pathways IRS4 participated on our site, such as cGMP-PKG signaling pathway,FoxO signaling pathway,AMPK signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IRS4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Regulation of lipolysis in adipocytes NPR1,GNAI1,PTGS1,TSHR,PNPLA2,PDE3B,INS,PTGER3,AKT1,LOC100328615
    cGMP-PKG signaling pathway NFATC4,AKT1,GNAI2,ATP1A1,ROCK1,NPR1,CALM3,MAPK1,PPP1CC,CALM2
    FoxO signaling pathway KLF2B,INS1,FBXO32,GRB2,IKBKB,PRKAB2,HOMER2,STK4,MAPK3,RAF1
    Type II diabetes mellitus MAPK10,PIK3CA,INS,PIK3CD,PIK3CB,PRKCZ,SOCS1,TNF,ADIPOQ,PIK3R5
    Adipocytokine signaling pathway ADIPOQ,POMCA,NFKBIAB,RXRBA,IRS1,IKBKB,G6PC3,NPY,NFKBIB,AKT2
    Insulin signaling pathway BADB,PPP1R3A,FOXO1A,PIK3R5,INPPL1A,IRS1,INSRB,PRKAG3B,FBP1A,RAPGEF1B
    AMPK signaling pathway SREBF1,TBC1D1,PPP2R5C,G6PC3,PIK3R1,ACACB,CCNA1,EEF2K,FOXO1,TSC2

    Protein Function

    IRS4 has several biochemical functions, for example, SH3/SH2 adaptor activity,insulin receptor binding,phosphatidylinositol 3-kinase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IRS4 itself. We selected most functions IRS4 had, and list some proteins which have the same functions with IRS4. You can find most of the proteins on our site.

    Function Related Protein
    insulin receptor binding DOK4,PDPK1,IGF1R,INSL3,SNX2,DOK1B,FRS2A,INS,SNX1,DOK3
    phosphatidylinositol 3-kinase binding PDGFRB,BECN1,IGF1R,INSRA,CALM1,INSRR,CALM3,JAK2,IGF1RA,ATP1A1
    SH3/SH2 adaptor activity GRB14,STAM,CHN2,TOB1,RUSC1,SLA,SH2D1A,CD28,FCRL2,SH3BP2
    protein binding CCDC170,PDIA3,ATG12,RPS6KC1,FHL2,EOMESA,CDKN1A,MRPL45,SIK3,SLC30A2
    signal transducer activity IL15RA,GNA11,RGS7,TAAR10B,VMN1R43,PLCD4,TAS2R108,GPR126,FZD1,NPY8BR

    Interacting Protein

    IRS4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IRS4 here. Most of them are supplied by our site. Hope this information will be useful for your research of IRS4.

    YWHAB;P;PTGES3;CRK;PPP2R2B;EGFR;ERBB2

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