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IRS2

Official Full Name

insulin receptor substrate 2
Overview

This gene encodes the insulin receptor substrate 2, a cytoplasmic signaling molecule that mediates effects of insulin,;insulin-like growth factor 1, and other cytokines by acting as a molecular adaptor between diverse receptor tyrosine;kinases and downstream effectors. The product of this gene is phosphorylated by the insulin receptor tyrosine kinase;upon receptor stimulation, as well as by an interleukin 4 receptor-associated kinase in response to IL4 treatment.
Synonyms

IRS2; insulin receptor substrate 2; IRS-2;

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse

Source

E.coli
HEK293
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
His|T7
N

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	IRS2-1051H	Recombinant Human IRS2 protein, His & T7-tagged	E.coli	His/T7	Ser985~Ala1255 (Accession # Q9Y4H2)	Inquiry
Human	IRS2-5029H	Recombinant Human IRS2 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	IRS2-3213H	Recombinant Human IRS2 Protein (Ser985-Ala1255), N-His tagged	E.coli	N-His	Ser985-Ala1255	Inquiry
Mouse	IRS2-8314M	Recombinant Mouse IRS2 Protein	Mammalian Cell	His		Inquiry
Mouse	IRS2-4611M	Recombinant Mouse IRS2 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	IRS2-4611M-B	Recombinant Mouse IRS2 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry

IRS2 involved in several pathways and played different roles in them. We selected most pathways IRS2 participated on our site, such as cGMP-PKG signaling pathway, FoxO signaling pathway, AMPK signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IRS2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
cGMP-PKG signaling pathway	PIK3R5;RGS2;MYH7;PDE2A;AKT2;NFATC2;GNAI1;Adcy4;PRKCE
FoxO signaling pathway	PIK3R1;BRAF;KLF2A;SMAD2;INS2;HRASB;PTENA;PRKAB1;ARAF
AMPK signaling pathway	RAB10;MTOR;PPP2R5A;PPP2R1A;IRS4;CPT1B;PPP2R2A;RAB14;PFKFB4
Insulin signaling pathway	SLC2A4;SREBF1;MKNK2A;SHC4;GSK3AA;PRKAG3B;FBP2;INPPL1;PRKAG2
Adipocytokine signaling pathway	LEPB;PRKAG2A;CD36;CAMKK2;PRKAG3;SLC2A1;ACSL3;IRS2;PPARGC1A
Regulation of lipolysis in adipocytes	PIK3R2;NPY1R;AKT2;PRKG2;PRKACA;PIK3R5;Adcy4;AQP7;LOC100328615
Type II diabetes mellitus	PKM;CACNA1G;PDX1;PKLR;PIK3CA;SOCS4;PIK3R3;PIK3R5;SOCS2
Insulin resistance	RPS6KA3B;PRKCQ;PRKCZ;INSRA;PIK3R3;SLC27A1A;RPS6KA3A;GYS1;AKT2
Non-alcoholic fatty liver disease (NAFLD)	COX6B2;NDUFA1;ATF4;COX6A2;GSK3B;PRKAB2;RXRA;MAPK9;COX7B2
MicroRNAs in cancer	CCNG1;EFNA3;PRKCB;SIRT1;TTC6;ST14;PLCG1;WNT3A;FGFR3

IRS2 has several biochemical functions, for example, 14-3-3 protein binding, insulin receptor binding, phosphatidylinositol 3-kinase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IRS2 itself. We selected most functions IRS2 had, and list some proteins which have the same functions with IRS2. You can find most of the proteins on our site.

Function	Related Protein
14-3-3 protein binding	YWHAQ;IRS2;RPTOR;AKT1;PPP1R12A;ZFP36;SRPK2;DDIT4;KCNH1
insulin receptor binding	DOK6;SNX2;IRS4;IRS1;DOK2;LMBRD1;ENPP1;DOK5;DOK1
phosphatidylinositol 3-kinase binding	CORO1A;CALM3;INSRR;PDGFRB;BECN1;IGF1RA;INSRA;IRS2;IGF1R
protein binding	CBX7;ATP6V1E1;PLD1;LAMA4;SFRP1;MORF4L2;SLC19A2;ATG3;KLK13
protein domain specific binding	WNT5A;MECP2;YWHABA;DICER1;TACC2;HIST1H4H;TADA3;MITD1;RUNX2
protein kinase binding	CCND3;KIF11;CDC25B;ATF2;RPS19;PRDX3;DPYSL2;USP37;NR4A3
protein phosphatase binding	ANAPC4;EGFR;SKAP1;JUPA;SNX3;SHOC2;JUP;ANAPC7;MAPK14

IRS2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IRS2 here. Most of them are supplied by our site. Hope this information will be useful for your research of IRS2.

Ncl; Znf592; Lonp1; TP53BP2; Insr; Phip; Sirt1; SIRT1; Lyn

Hancer, NJ; Qiu, W; et al. Insulin and Metabolic Stress Stimulate Multisite Serine/Threonine Phosphorylation of Insulin Receptor Substrate 1 and Inhibit Tyrosine Phosphorylation. JOURNAL OF BIOLOGICAL CHEMISTRY 289:12467-12484(2014).

Zerzaihi, O; Chriett, S; et al. Insulin-dependent transcriptional control in L6 rat myotubes is associated with modulation of histone acetylation and accumulation of the histone variant H2A.Z in the proximity of the transcriptional start site. BIOCHEMISTRY AND CELL BIOLOGY-BIOCHIMIE ET BIOLOGIE CELLULAIRE 92:61-67(2014).

Endocrine Regulation of Lipid Metabolism

phospho-Serine/phospho-Threonine Binding Proteins