IRS2

  • Official Full Name

    insulin receptor substrate 2

  • Overview

    This gene encodes the insulin receptor substrate 2, a cytoplasmic signaling molecule that mediates effects of insulin,;insulin-like growth factor 1, and other cytokines by acting as a molecular adaptor between diverse receptor tyrosine;kinases and downstream effectors. The product of this gene is phosphorylated by the insulin receptor tyrosine kinase;upon receptor stimulation, as well as by an interleukin 4 receptor-associated kinase in response to IL4 treatment.

  • Synonyms

    IRS2;insulin receptor substrate 2;IRS-2
Cat.# Product name Source (Host) Species Tag Protein Length Price
IRS2-1051H Recombinant Human IRS2 protein, His & T7-tagged E.coli Human His&T7 Ser985~Ala1255
IRS2-8314M Recombinant Mouse IRS2 Protein Mammalian Cells Mouse His
IRS2-3213H Recombinant Human IRS2 Protein (Ser985-Ala1255), N-His tagged E.coli Human His Ser985-Ala1255
IRS2-4611M Recombinant Mouse IRS2 Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
IRS2-4611M-B Recombinant Mouse IRS2 Protein Pre-coupled Magnetic Beads HEK293 Mouse
IRS2-5029H Recombinant Human IRS2 Protein, GST-tagged Wheat Germ Human GST

    Involved Pathway

    IRS2 involved in several pathways and played different roles in them. We selected most pathways IRS2 participated on our site, such as cGMP-PKG signaling pathway,FoxO signaling pathway,AMPK signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IRS2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    FoxO signaling pathway IGF1RA,EGFRA,IGF1RB,CDKN1BA,AKT2L,PRKAB2,MAPK12B,GRB2B,IKBKB,KLF2A
    Insulin signaling pathway GRB2B,FBP1,NRAS,RHEB,PIK3CD,SREBF1,TSC1B,BRAF,SOCS2,PPP1CAA
    AMPK signaling pathway PPP2R3A,SLC2A4,CAMKK2,PIK3R5,FASN,PRKAG3,CREB3L1,STRADB,RAB14,PFKM
    Type II diabetes mellitus INS,PRKCE,PKM,PIK3CA,HK1,SLC2A4,PIK3R3,PIK3CG,PIK3R2,SOCS3
    cGMP-PKG signaling pathway ATP1A3,MYH7,ATP1B3,SLC8A1,PDE3B,SRF,ATP2A1,PPIF,PPP1CC,KCNMB3
    Regulation of lipolysis in adipocytes NPR1,Adcy4,PIK3CA,PRKACA,PTGS2,PRKG2,AKT2,PIK3R5,ABHD5,TSHB
    Insulin resistance IRS1,PPP1CAA,IKBKB,PYGMA,CREB1A,MAPK9,PRKCBA,IL6,PCK1,PPP1CC
    Adipocytokine signaling pathway NFKBIA,ACSL1A,SLC2A1,PTPN11,CHUK,RXRGB,PPARGC1A,STAT3,CAMKK1A,LEPA
    Non-alcoholic fatty liver disease (NAFLD) PPARA,MAP3K11,SREBF1,COX7A1,PKLR,PRKAB1,SOCS3,UQCRC2,EIF2AK3,ITCH

    Protein Function

    IRS2 has several biochemical functions, for example, 14-3-3 protein binding,insulin receptor binding,phosphatidylinositol 3-kinase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IRS2 itself. We selected most functions IRS2 had, and list some proteins which have the same functions with IRS2. You can find most of the proteins on our site.

    Function Related Protein
    protein phosphatase binding EGFR,CDKN1B,KAT2A,FGF19,CSK,DLG4,JAK1,STAT3,ANAPC4,PPP1R3G
    insulin receptor binding SHC1,DOK1,LMBRD1,PHIP,GRB10,INS1,DOK2,PIK3R1,PDPK1,DOK3
    protein kinase binding CCND2,SNAP91,DNM1,CDKN2C,RPS6,TRAF6,HCLS1,CAMK2N1,TOM1L1,TPCN2
    phosphatidylinositol 3-kinase binding BECN1,TYRO3,PDGFRB,IRS1,INSRA,INSRB,FLT3,DAB1,FYN,LCK
    14-3-3 protein binding ZFP36,ARRB2,TSC2,PPP1R12A,KIF13B,KCNH1,AANAT,AKT1,SRPK2,DDIT4
    protein domain specific binding NEFL,COX4I2,VAPA,CTBP1,LAMP1,DRD3,DDC,TRP63,E2F4,PPARA
    protein binding FFAR2,TEX10,PINK1,TLE4,HTR6,VARS,NUPL1,USP19,PPP2R5D,FAM189B

    Interacting Protein

    IRS2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IRS2 here. Most of them are supplied by our site. Hope this information will be useful for your research of IRS2.

    Ncl;Znf592;Lonp1;TP53BP2;Insr;Phip;Sirt1;SIRT1;Lyn

    Resources

    Gene Families

    What Is Tumor Necrosis Factor (TNF)/TNF Superfamily

    Research Area

    phospho-Serine/phospho-Threonine Binding Proteins
    Endocrine Regulation of Lipid Metabolism

    References

    • Hancer, NJ; Qiu, W; et al. Insulin and Metabolic Stress Stimulate Multisite Serine/Threonine Phosphorylation of Insulin Receptor Substrate 1 and Inhibit Tyrosine Phosphorylation. JOURNAL OF BIOLOGICAL CHEMISTRY 289:12467-12484(2014).
    • Zerzaihi, O; Chriett, S; et al. Insulin-dependent transcriptional control in L6 rat myotubes is associated with modulation of histone acetylation and accumulation of the histone variant H2A.Z in the proximity of the transcriptional start site. BIOCHEMISTRY AND CELL BIOLOGY-BIOCHIMIE ET BIOLOGIE CELLULAIRE 92:61-67(2014).

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