Recombinant Human NRTN protein
| Cat.No. : | NRTN-29535TH |
| Product Overview : | Recombinant Human NRTN protein was expressed in Escherichia coli. |
- Specification
- Gene Information
- Related Products
| Description : | This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate the mature protein. This protein signals through the RET receptor tyrosine kinase and a GPI-linked coreceptor, and promotes survival of neuronal populations. A neurturin mutation has been described in a family with Hirschsprung Disease. |
| Source : | E.coli |
| Species : | Human |
| Form : | Lyophilized from a 0.2μm filtered concentrated solution in 30 mM Citrate Sodium, pH 4.2, 400 mM NaCl, with 0.02 % Tween-20. |
| Bio-activity : | Fully biologically active when compared to standard. The biologically active as determined by its binding ability in a functional ELISA. |
| Molecular Mass : | Approximately 23.4 kDa, a homodimeric protein consisting of two 102 amino acid non-glycosylated polypeptide chains. |
| Protein length : | 102 |
| AA Sequence : | ARLGARPCGLRELEVRVSELGLGYA SDETVLFRYCAGACEAAARVYDLGL RRLRQRRRLRRERVRAQPCCRPTAY EDEVSFLDAHSRYHTVHELSARECA CV |
| Endotoxin : | Less than 1 EU/μg of rHuNeurturin as determined by LAL method. |
| Purity : | >96% by SDS-PAGE and HPLC analysis. |
| Storage : | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 centigrade as supplied. 1 month, 2 to 8 centigrade under sterile conditions after reconstitution. 3 months, -20 to -70 centigrade under sterile conditions after reconstitution. |
| Reconstitution : | We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water to a concentration of 0.5 mg/mL. Stock solutions should be apportioned into working aliquots and stored at ≤-20 centigrade. Further dilutions should be made in appropriate buffered solutions. |
| Gene Name : | NRTN |
| Official Symbol : | NRTN |
| Synonyms : | NRTN; neurturin; NTN; |
| Gene ID : | 4902 |
| mRNA Refseq : | NM_004558 |
| Protein Refseq : | NP_004549 |
| MIM : | 602018 |
| UniProt ID : | Q99748 |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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