"DNMT3A" Related Products


Recombinant Human DNMT3A, GST-tagged

Cat. No. : DNMT3A-513H
Product Overview : Recombinant Human DNMT3a, (a-a 2-913), with N-terminal GST tag expressed inbaculovirus. MW= 128 kDa.
Description : CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase that is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes to the cytoplasm and nucleus and its expression is developmentally regulated. Alternative splicing results in multiple transcript variants encoding different isoforms.
Source : Baculovirus.
Purity : >50%.
Application : Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Formulated In : 25 mM Tris-HCl, pH 8.0, 100 mM NaCl, 0.05% Tween-20 and 10% glycerol.
Stability : >6 months at –80°C.
Gene Name : DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha [ Homo sapiens ]
Synonyms : DNMT3A; DNA (cytosine-5-)-methyltransferase 3 alpha; DNMT3A2; M.HsaIIIA; EC; DNA MTase HsaIIIA; DNA methyltransferase HsaIIIA; DNA cytosine methyltransferase 3A2; DNA (cytosine-5)-methyltransferase 3A; Dnmt3a; DNA MTase HsaIIIA
Gene ID : 1788
mRNA Refseq : NM_022552
Protein Refseq : NP_072046
MIM : 602769
UniProt ID : Q9Y6K1
Chromosome Location : 2p23
Pathway : Cysteine and methionine metabolism; Metabolic pathways
Function : DNA (cytosine-5-)-methyltransferase activity; DNA binding; metal ion binding; chromatin binding; transferase activity; zinc ion binding

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