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  • Official Full Name

    DNA (cytosine-5-)-methyltransferase 1

  • Overview

    DNA (cytosine-5-)-methyltransferase 1 has a role in the establishment and regulation of tissue-specific patterns of methylated cytosine residues. Aberrant methylation patterns are associated with certain human tumors and developmental abnormalities. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
  • Synonyms

    DNMT1; DNA (cytosine-5-)-methyltransferase 1; AIM; DNMT; MCMT; CXXC9; HSN1E; ADCADN; DNA (cytosine-5)-methyltransferase 1; m.HsaI; DNA MTase HsaI; DNA methyltransferase HsaI; CXXC-type zinc finger protein 9;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Assay Kits
  • Chicken
  • Human
  • Mouse
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Insect Cell
  • Insect Cells
  • Mammalian Cell
  • Mammalian cells
  • Sf9 Insect Cell
  • Sf9 insect cells
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • His|Flag
  • His|T7
  • FLAG
  • tag
  • Myc
  • DDK
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human DNMT1-198H Active Recombinant Human DNMT1 protein, MYC/DDK-tagged HEK293 Myc/DDK
Human DNMT1-201HFL Active Recombinant Full Length Human DNMT1 Protein, C-Flag-tagged Mammalian cells Flag
Human DNMT1-388H Recombinant Human DNMT1, His-tagged Insect Cell His
Human DNMT1-199H Recombinant Human DNMT1 protein, GST-tagged Wheat Germ GST 1 a.a. - 110 a.a.
Human DNMT1-72H Recombinant Human DNMT1 protein, GST-tagged Insect Cell GST 2-1632
Human DNMT1-511H Recombinant Human DNMT1, GST-tagged Insect Cell GST
Human DNMT1-2633H Recombinant Human DNMT1 protein, His-tagged E.coli His 1288-1632 aa
Human DNMT1-1645H Recombinant Human DNMT1 protein, His & T7-tagged E.coli His/T7 Val1343~Leu1570 (Accession # P26358)
Human DNMT127873H Recombinant Human DNMT1 (726-1600) Protein, His-tagged E.coli His
Human DNMT1-330H Recombinant Human DNMT1 Protein, His-Flag-tagged Insect Cells His/Flag
Human DNMT1-01H Recombinant Human DNMT1 protein, His-FLAG-tagged Sf9 insect cells His-FLAG-tag
Human DNMT1-778H Recombinant Human DNMT1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human DNMT1-778H-B Recombinant Human DNMT1 Protein Pre-coupled Magnetic Beads HEK293
Human DNMT1153H Recombinant Human DNMT1 (621-1616) Protein, His-tagged E.coli His
Human DNMT130392H Recombinant Human DNMT1 (646-1600) Protein, His-tagged E.coli His
Mouse Dnmt1-139M Active Recombinant Mouse Dnmt1 Insect Cell N/A
Mouse DNMT1-6950M Recombinant Mouse DNMT1, GST-tagged Sf9 Insect Cell GST 766 aa-end
Mouse DNMT13547M Recombinant Mouse DNMT1 (731-1602) Protein
Mouse Dnmt1-2620M Recombinant Mouse Dnmt1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Zebrafish DNMT1-8794Z Recombinant Zebrafish DNMT1 Mammalian Cell His
Chicken DNMT1-7096C Recombinant Chicken DNMT1 Mammalian Cell His
Kit-1715 DNMT1 Chemiluminescent Assay Kit N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • DNMT1 Related Articles
  • DNMT1 Related Research Area

DNMT1 involved in several pathways and played different roles in them. We selected most pathways DNMT1 participated on our site, such as Cysteine and methionine metabolism, DNA methylation, Epigenetic regulation of gene expression, which may be useful for your reference. Also, other proteins which involved in the same pathway with DNMT1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cysteine and methionine metabolismMTAP;DNMT3;MDH1AA;CBSA;MAT2A;GSS;AHCYL2;APIP;LDHA
Epigenetic regulation of gene expressionPHF1;TET3;SUZ12;H3F3D;TET1;TAF1C;MTF2;SAP30BP;EED
Gene ExpressionZNF606;ZNF234;SETB;ZNF786;USP9X;KRBOX4;ZNF70;ZNF333;WHSC2
Negative epigenetic regulation of rRNA expressionSUDS3;EFCAB11;SAP30BP;SAP30;TAF1A;SAP130;TAF1B;DNMT3B;DNMT1
NoRC negatively regulates rRNA expressionTAF1D;SUDS3;SIN3B;SAP130;BAZ2A;TAF1B;DNMT3B;CD3EAP;TAF1C

DNMT1 has several biochemical functions, for example, DNA (cytosine-5-)-methyltransferase activity, DNA binding, DNA-methyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DNMT1 itself. We selected most functions DNMT1 had, and list some proteins which have the same functions with DNMT1. You can find most of the proteins on our site.

Function Related Protein
DNA (cytosine-5-)-methyltransferase activityDNMT3A;DNMT1;TRDMT1;DNMT3B
DNA-methyltransferase activityRNMTL1A;TRMT10C;DNMT3A;METTL8;METTL21D;DNMT1;FAM86;FBLL1;PRDM12
chromatin bindingGLI2;HDGFRP2;HOXD13;ATAD2;MB21D2;TRP63;ZFP143;SMC1A;RBPJ
methyl-CpG bindingMBD3A;MBD3;ZBTB33;LRWD1;UHRF1;ZNF295;ZBTB4;MBD1;DNMT1
protein bindingEEF1B2;ZNF821;SELE;EPB41;PAX9;IFT43;PSMC4;SPINK1;RRAGA
transcription factor bindingIFT172;KCTD1;ZFPM2;HDAC3;JUND;HES7;NKX3-1;REST;AIP
zinc ion bindingMAP3K7IP3;ZFAND5;MKRN3;USP39;HRG;ZNF185;FHL1A;Npepo;MT1M

DNMT1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DNMT1 here. Most of them are supplied by our site. Hope this information will be useful for your research of DNMT1.

Banerjee, J; Mishra, R; et al. A reciprocal role of prostate cancer on stromal DNA damage. ONCOGENE 33:4924-4931(2014).
Yuan, LQ; Chan, GCF; et al. RANKL expression in myeloma cells is regulated by a network involving RANKL promoter methylation, DNMT1, microRNA and TNF alpha in the microenvironment. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH 1843:1834-1838(2014).
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