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Official Full Name DNA (cytosine-5-)-methyltransferase 1
Background DNA (cytosine-5-)-methyltransferase 1 has a role in the establishment and regulation of tissue-specific patterns of methylated cytosine residues. Aberrant methylation patterns are associated with certain human tumors and developmental abnormalities. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
Synonyms DNMT1; DNA (cytosine-5-)-methyltransferase 1; AIM; DNMT; MCMT; CXXC9; HSN1E; ADCADN; DNA (cytosine-5)-methyltransferase 1; m.HsaI; DNA MTase HsaI; DNA methyltransferase HsaI; CXXC-type zinc finger protein 9;
    • Species :
    • Chicken
    • Human
    • Mouse
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Insect Cell
    • Insect Cells
    • Mammalian Cell
    • Sf9 Insect Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • Flag
    • T7
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human DNMT1-1645H Recombinant Human DNMT1 protein, His & T7-tagged E.coli His/T7
    Human DNMT1-198H Recombinant Human DNMT1 protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human DNMT1-199H Recombinant Human DNMT1 protein, GST-tagged Wheat Germ GST
    Human DNMT1-330H Recombinant Human DNMT1 Protein, His-Flag-tagged Insect Cells His/Flag
    Human DNMT1-388H Recombinant Human DNMT1, His-tagged Insect Cell His
    Human DNMT1-511H Recombinant Human DNMT1, GST-tagged Insect Cell GST
    Human DNMT1-72H Recombinant Human DNMT1 protein, GST-tagged Insect Cell GST
    Mouse Dnmt1-139M Recombinant Mouse Dnmt1 Insect Cell N/A
    Mouse Dnmt1-2620M Recombinant Mouse Dnmt1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Mouse DNMT1-6950M Recombinant Mouse DNMT1, GST-tagged Sf9 Insect Cell GST
    Chicken DNMT1-7096C Recombinant Chicken DNMT1 Mammalian Cell His
    Zebrafish DNMT1-8794Z Recombinant Zebrafish DNMT1 Mammalian Cell His
    Kit-1715 DNMT1 Chemiluminescent Assay Kit N/A

    dnmt1 involved in several pathways and played different roles in them. We selected most pathways dnmt1 participated on our site, such as Cysteine and methionine metabolism, DNA methylation, Epigenetic regulation of gene expression, which may be useful for your reference. Also, other proteins which involved in the same pathway with dnmt1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cysteine and methionine metabolism CTH; MPST; ADI1; DNMT3AA; MAT2B; DNMT1; MDH2; APIP; MDH1AA; AHCYL1
    DNA methylation DNMT3B; DNMT1; DNMT3A; UHRF1; DNMT3L
    Epigenetic regulation of gene expression SAP30; TAF1A; SUZ12; SUZ12B; PHF19; AEBP2; SAP30L; SUDS3; CD3EAP; EED
    Gene Expression RRP8; ZNF468; ZNF383; DNMT3L; SF3A1; COX7C; C14orf166; NR2C2; COX5B; ZNF2
    Metabolic pathways ALG9; Acsm2a; ALDH1A2; UGT2A3; GCSHA; PLA2G6; PNMT; PRIM1; NDUFS8B; CYP2P6
    MicroRNAs in cancer NOTCH2; IRS1; SOX4; SOS1; MET; PDGFA; MDM4; CCNE1; VIM; NOTCH4
    Negative epigenetic regulation of rRNA expression SUDS3; SIN3B; TAF1D; CD3EAP; EFCAB11; BAZ2A; RRP8; TAF1B; SAP18; DNMT3B
    NoRC negatively regulates rRNA expression EFCAB11; BAZ2A; TAF1A; SUDS3; TAF1B; TAF1C; SIN3B; SAP130; DNMT3B; DNMT1

    dnmt1 has several biochemical functions, for example, DNA (cytosine-5-)-methyltransferase activity, DNA binding, DNA-methyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by dnmt1 itself. We selected most functions dnmt1 had, and list some proteins which have the same functions with dnmt1. You can find most of the proteins on our site.

    Function Related Protein
    DNA (cytosine-5-)-methyltransferase activity DNMT3B; TRDMT1; DNMT3A; DNMT1
    DNA binding HOXB2; ONECUTL; ZBTB12; ARID4A; POLR3F; PROX1; ZFP191; RB1; HOXD12; ZFP35
    DNA-methyltransferase activity RNMTL1B; METTL21D; METTL21A; PRDM12; TRMT10B; RNMTL1A; PRMT8B; NDUFAF5; METTL8; DNMT3AA
    chromatin binding HMG20B; PRDM11; CRTC2; HMGB2B; JUB; CHD8; BRD3; ZKSCAN3; ATOH1A; SOX14
    methyl-CpG binding MECP2; MBD3; MBD1; MBD1B; MBD3A; MBD3B; ZNF295; MBD3L1; ZBTB4; UHRF1
    protein binding FTH1; KCNJ3; SEMG2; FAM50B; C7orf53; NUTF2; PODXL2; DNAJC10; ZNF614; CCDC41
    transcription factor binding ATOH8; APBB3; TRAPPC2; PPP1R13BB; ETS1; MED25; RBL1; GTF2A2; PAX2; SMARCA4
    zinc ion binding ZNF385C; RNF212; BMI1; TRIM35-34; MIB2; TRIM54; MT1H; MARCH8; ZRANB3; CSRP3

    dnmt1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with dnmt1 here. Most of them are supplied by our site. Hope this information will be useful for your research of dnmt1.

    Banerjee, J; Mishra, R; et al. A reciprocal role of prostate cancer on stromal DNA damage. ONCOGENE 33:4924-4931(2014).
    Yuan, LQ; Chan, GCF; et al. RANKL expression in myeloma cells is regulated by a network involving RANKL promoter methylation, DNMT1, microRNA and TNF alpha in the microenvironment. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH 1843:1834-1838(2014).

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