Recombinant Human DNMT3A Protein, GST-tagged

• Cat.No.: DNMT3A-2790H
• Product Overview: Human DNMT3A full-length ORF ( NP_072046.2, 1 a.a. - 912 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase that is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes to the cytoplasm and nucleus and its expression is developmentally regulated. [provided by RefSeq, Mar 2016]
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 128.3 kDa
• AA Sequence: MPAMPSSGPGDTSSSAAEREEDRKD GEEQEEPRGKEERQEPSTTARKVGR PGRKRKHPPVESGDTPKDPAVISKS PSMAQDSGASELLPNGDLEKRSEPQ PEEGSPAGGQKGGAPAEGEGAAETL PEASRAVENGCCTPKEGRGAPAEAG KEQKETNIESMKMEGSRGRLRGGLG WESSLRQRPMPRLTFQAGDPYYISK RKRDEWLARWKREAEKKAKVIAGMN AVEENQGPGESQKVEEASPPAVQQP TDPASPTVATTPEPVGSDAGDKNAT KAGDDEPEYEDGRGFGIGELVWGKL RGFSWWPGRIVSWWMTGRSRAAEGT RWVMWFGDGKFSVVCVEKLMPLSSF CSAFHQATYNKQPMYRKAIYEVLQV ASSRAGKLFPVCHDSDESDTAKAVE VQNKPMIEWALGGFQPSGPKGLEPP EEEKNPYKEVYTDMWVEPEAAAYAP PPPAKKPRKSTAEKPKVKEIIDERT RERLVYEVRQKCRNIEDICISCGSL NVTLEHPLFVGGMCQNCKNCFLECA YQYDDDGYQSYCTICCGGREVLMCG NNNCCRCFCVECVDLLVGPGAAQAA IKEDPWNCYMCGHKGTYGLLRRRED WPSRLQMFFANNHDQEFDPPKVYPP VPAEKRKPIRVLSLFDGIATGLLVL KDLGIQVDRYIASEVCEDSITVGMV RHQGKIMYVGDVRSVTQKHIQEWGP FDLVIGGSPCNDLSIVNPARKGLYE GTGRLFFEFYRLLHDARPKEGDDRP FFWLFENVVAMGVSDKRDISRFLES NPVMIDAKEVSAAHRARYFWGNLPG MNRPLASTVNDKLELQECLEHGRIA KFSKVRTITTRSNSIKQGKDQHFPV FMNEKEDILWCTEMERVFGFPVHYT DVSNMSRLARQRLLGRSWSVPVIRH LFAPLKEYFACV
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha [ Homo sapiens ]
• Official Symbol: DNMT3A
• Synonyms: DNMT3A; DNA (cytosine-5-)-methyltransferase 3 alpha; DNA (cytosine-5)-methyltransferase 3A; DNA MTase HsaIIIA; DNA cytosine methyltransferase 3A2; DNMT3A2; M.HsaIIIA
• Gene ID: 1788
• mRNA Refseq: NM_022552
• Protein Refseq: NP_072046
• MIM: 602769
• UniProt ID: Q9Y6K1