dnmt3a
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  • Official Full Name
  • DNA (cytosine-5-)-methyltransferase 3 alpha
  • Background
  • CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase that is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes to the cytoplasm and nucleus and its expression is developmentally regulated. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
  • Synonyms
  • DNMT3A; DNA (cytosine-5-)-methyltransferase 3 alpha; DNMT3A2; M.HsaIIIA; DNA (cytosine-5)-methyltransferase 3A; DNA MTase HsaIIIA; DNA cytosine methyltransferase 3A2;
Cat.#:DNMT3A-2790HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human DNMT3A Protein, GST-tagged
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Cat.#:DNMT3A-12110HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human DNMT3A, GST-tagged
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Cat.#:DNMT3A-164HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human DNMT3A, GST-tagged
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Cat.#:DNMT3A-26885THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human DNMT3A, His-tagged
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Cat.#:DNMT3A-390HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human DNMT3A, His-tagged
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Cat.#:DNMT3A-73HTag:GST
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human DNM3A protein, GST-tagged
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Cat.#:DNMT3A-4741MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse DNMT3A Protein
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Cat.#:DNMT3A-1926RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat DNMT3A Protein
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Cat.#:DNMT3A-2202CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken DNMT3A
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Cat.#:DNMT3A-513HTag:GST
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human DNMT3A, GST-tagged
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Cat.#:DNMT3A-6855HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human DNMT3A 293 Cell Lysate
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Involved Pathway

DNMT3A involved in several pathways and played different roles in them. We selected most pathways DNMT3A participated on our site, such as Chromatin modifying enzymes, Chromatin organization, Cysteine and methionine metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with DNMT3A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Chromatin modifying enzymes
ARID5B; ELP2; C20orf20; EPC1; BRD8; MSL2B; BRPF3; MBD3A; DPY30; SMARCB1B
Chromatin organization
KDM5BB; ATF7IP; SUZ12; CHD4A; KDM5B; PHF21A; PBRM1; KDM2B; WDR77; MSL1A
Cysteine and methionine metabolism
CBS; LDHC; MDH1; LDHBB; GCLC; AHCYL1; DNMT3AB; CDO1; LDHAL6B; MDH2
DNA methylation
DNMT3L; DNMT1; DNMT3A; DNMT3B; UHRF1
Epigenetic regulation of gene expression
JARID2; RBB4L; SUZ12A; H3F3B.1; TAF1B; SUDS3; EFCAB11; MTF2; PHF1; TAF1C
Gene Expression
POLR3F; PTBP1A; ELAC2; CBX3; ZNF443; PCBP2; PRMT5; ZNF562; ZNF544; ZNF202
Metabolic pathways
ACSBG2; DBH; ALPL; PYCR2; PTGES2; GATM; POLR2J2; SDHC; FUT9A; HYAL1
MicroRNAs in cancer
SHC4; TRP53; CCND2; TTC6; HMOX1; ABCC1; BAK1; MAP2K2; VIM; BCL2

Protein Function

DNMT3A has several biochemical functions, for example, DNA (cytosine-5-)-methyltransferase activity, DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates, DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DNMT3A itself. We selected most functions DNMT3A had, and list some proteins which have the same functions with DNMT3A. You can find most of the proteins on our site.
Function
Related Protein
Function DNA (cytosine-5-)-methyltransferase activity
Related Protein DNMT3B; DNMT3A; DNMT1; TRDMT1
Function DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates
Related Protein DNMT3A; DNMT3B
Function DNA binding
Related Protein MSXD; TCF3; BCL3; FOXO1A; APEX2; EEF1D; GTF2IRD1; TLX2; NFATC2; TCF4
Function DNA-methyltransferase activity
Related Protein NDUFAF5; FAM86; PRDM11; PRMT8B; MGMT; FBLL1; RNMTL1B; METTL21D; DNMT4; RNMTL1A
Function chromatin binding
Related Protein HHEX; ERG; RNF168; LDB2A; FOS; TOX2; CBX5; FOXO1; UBTF; SMARCA2
Function identical protein binding
Related Protein EPHA4; FRS3; IFIT3; RASSF3; MICALL1; NCL; CCDC109A; ALDOA; TRAF2; ATXN3
Function metal ion binding
Related Protein CYP4V7; NOS2A; NPSN; MYLIPB; TRIM35-19; NAALADL1; ATP13A3; GLI2B; GTF2H3; ZFP423
Function protein binding
Related Protein PCMT1; ZBTB25; ULK1; POLR3C; CASP10; NFYB; PDLIM2; ETV6; UNC119; FAM113B
Function unmethylated CpG binding
Related Protein DNMT3B; MLL1; KDM2A; CXXC1; DNMT3A

Interacting Protein

DNMT3A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DNMT3A here. Most of them are supplied by our site. Hope this information will be useful for your research of DNMT3A.
EZH2; H3F3A; SETDB1

DNMT3A Related Articles

Deplus, R; Blanchon, L; et al. Regulation of DNA Methylation Patterns by CK2-Mediated Phosphorylation of Dnmt3a. CELL REPORTS 8:743-753(2014).
Ahearne, MJ; Allchin, RL; et al. Follicular helper T-cells: expanding roles in T-cell lymphoma and targets for treatment. BRITISH JOURNAL OF HAEMATOLOGY 166:326-335(2014).