DNMT3B

  • Official Full Name

    Dnmt3b DNA methyltransferase 3B

  • Overview

    Dnmt3b (DNA (cytosine-5-)-methyltransferase 3b) has a role in the establishment and regulation of tissue-specific patterns of methylated cytosine residues (epigenetics). Dnmt3b is thought to function in de novo methylation rather than maintenance methylation. The protein localizes primarily to the nucleus and its expression is developmentally regulated. Mutations in this gene cause the immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome.
  • Synonyms

    DNMT3B; DNA methyltransferase 3B; DNA (cytosine-5)-methyltransferase 3B; m.MmuIIIB; DNA MTase MmuIIIB; DNA methyltransferase MmuIIIB; MGC124407;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Assay Kits
  • Chicken
  • Human
  • Mouse
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293F
  • HEK293T
  • In Vitro Cell Free System
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Sf9 Insect Cell
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • His|T7
  • Myc
  • DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human DNMT3B-165H Active Recombinant Human DNMT3B, GST-tagged Sf9 Insect Cell GST
Human DNMT3B-74H Recombinant Human DNMT3B protein, GST-tagged Insect Cell GST 2-853
Human DNMT3B-2792H Recombinant Human DNMT3B Protein, GST-tagged Wheat Germ GST
Human DNMT3B-26884TH Recombinant Human DNMT3B Wheat Germ N/A 100 amino acids
Human DNMT3B-6854HCL Recombinant Human DNMT3B 293 Cell Lysate HEK293 N/A
Human DNMT3B-3712H Recombinant Human DNMT3B protein, GST-tagged E.coli GST 1-100 aa
Human DNMT3B-895H Recombinant Human DNMT3B Protein, His-tagged HEK293F N-His Ser145-Pro355
Human DNMT3B-1360H Recombinant Human DNMT3B Protein, His&GST-tagged E.coli N-His&GST Glu206-Pro355
Human DNMT3B-4643H Recombinant Human DNMT3B Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human DNMT3B-334HFL Active Recombinant Full Length Human DNMT3B Protein, C-Flag-tagged Mammalian cells Flag
Human DNMT3B-780H-B Recombinant Human DNMT3B Protein Pre-coupled Magnetic Beads HEK293
Human DNMT3B-4052HF Recombinant Full Length Human DNMT3B Protein, GST-tagged In Vitro Cell Free System GST 770 amino acids
Human DNMT3B-780H Recombinant Human DNMT3B Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human DNMT3B-1979H Recombinant Human DNMT3B Protein (Met1-Ser100), N-His tagged E.coli N-His Met1-Ser100
Mouse Dnmt3b-1646M Recombinant Mouse Dnmt3b protein, His & T7-tagged E.coli His/T7 Ile581~Glu859 (Accession # O88509)
Mouse Dnmt3b-2622M Recombinant Mouse Dnmt3b Protein, Myc/DDK-tagged HEK293T Myc/DDK
Zebrafish DNMT3B-2680Z Recombinant Zebrafish DNMT3B Mammalian Cell His
Chicken DNMT3B-2198C Recombinant Chicken DNMT3B Mammalian Cell His
Kit-1716 DNMT3B Chemiluminescent Assay Kit N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • DNMT3B Related Articles
  • DNMT3B Related Research Area

DNMT3B involved in several pathways and played different roles in them. We selected most pathways DNMT3B participated on our site, such as Cysteine and methionine metabolism, DNA methylation, Epigenetic regulation of gene expression, which may be useful for your reference. Also, other proteins which involved in the same pathway with DNMT3B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cysteine and methionine metabolismMAT2A;GOT2A;DNMT3AB;TST;APIP;LDHBB;MAT2B;CBSA;GOT2
DNA methylationUHRF1;DNMT3B;DNMT3A;DNMT3L;DNMT1
Epigenetic regulation of gene expressionTET1;SAP30BP;TAF1C;TAF1B;DNMT1;SAP18;UHRF1;SUZ12B;SMARCA5
Gene ExpressionPOLR3H;TRDMT1;ZNF785;ZFP1;PUS1;POP1;ZNF548;NR2F6B;ZNF684
Metabolic pathwaysATP5IB;PAFAH1B2;LSS;ATP6V1C1;HAL;PCXB;NDUFS8B;ACSL4B;ALDH5A1
MicroRNAs in cancerPLCG2;RPS6KA5;PDGFRB;HDAC4;TNC;CDC25A;TRP53;NOTCH4;PLAU
Negative epigenetic regulation of rRNA expressionSAP130;TAF1D;EFCAB11;SAP18;SAP30L;SAP30;SAP30BP;TAF1A;TAF1B
NoRC negatively regulates rRNA expressionSAP30L;TAF1B;SIN3B;TAF1A;SAP30BP;CD3EAP;DNMT1;SUDS3;BAZ2A

DNMT3B has several biochemical functions, for example, DNA (cytosine-5-)-methyltransferase activity, DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates, DNA-methyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DNMT3B itself. We selected most functions DNMT3B had, and list some proteins which have the same functions with DNMT3B. You can find most of the proteins on our site.

Function Related Protein
DNA (cytosine-5-)-methyltransferase activityTRDMT1;DNMT3B;DNMT3A;DNMT1
DNA (cytosine-5-)-methyltransferase activity, acting on CpG substratesDNMT3A;DNMT3B
DNA-methyltransferase activityPRMT8B;METTL23;DNMT3AA;RNMTL1B;PRDM13;DIMT1;DNMT3B;TRMT10C;RNMTL1A
chromatin bindingPDX1;UBE2T;SALL1;SMARCE1;TFAM;ASH1L;KDM8;ZEB1;ING5
histone deacetylase bindingHES1;GCM1;CEBPA;NRIP1;DHX36;CRY1;PARK2;RBBP4;NCOR1
metal ion bindingCAR15;RARGA;Fcer2a;BMX;NEURL1AB;NEK5;CTDSPL;CPD;ADAM25
protein bindingPAF1;ICA1;NINJ1;DNAJA3;MYCN;ZCCHC7;AZGP1;INCENP;ZNF346
transcription corepressor activityHDAC5;GPS2;WWTR1;PIAS1;LHX1A;TRIM22;EID1;RLIM;DMAP1
unmethylated CpG bindingDNMT3B;MLL1;CXXC1;KDM2A;DNMT3A

DNMT3B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DNMT3B here. Most of them are supplied by our site. Hope this information will be useful for your research of DNMT3B.

EZH2; EED; SUMO1; UHRF1

Gonzalez-Bosquet, J; Chu, YL; et al. Development of an Intracellular, DNA Methyltransferase-Specific, and Gene-Specific Assay for Studying Dynamic DNA Methylation. CURRENT PHARMACEUTICAL DESIGN 20:1664-1673(2014).
Zhou, HY; Li, JP; et al. Hypomethylation and Activation of Syncytin-1 Gene in Endometriotic Tissue. CURRENT PHARMACEUTICAL DESIGN 20:1786-1795(2014).
  • Q&As
  • Reviews

Q&As (5)

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What are the potential side effects of targeting DNMT3B for therapeutic purposes? 12/04/2022

Targeting DNMT3B for therapeutic purposes may lead to off-target effects and unintended changes in DNA methylation, potentially causing adverse effects on normal cellular function and gene expression.

Are there any genetic disorders associated with mutations in the DNMT3B gene? 03/29/2021

Yes, mutations in the DNMT3B gene are linked to a rare genetic disorder called ICF (Immunodeficiency, Centromeric instability, Facial anomalies) syndrome, characterized by immune system deficiencies, facial abnormalities, and unstable centromeric regions in chromosomes.

Can DNMT3B protein be used as a potential biomarker for cancer diagnosis or prognosis? 11/08/2020

Research has shown that alterations in DNMT3B expression or activity can be associated with various types of cancer, making it a potential biomarker for cancer diagnosis, prognosis, and treatment response.

How does DNMT3B protein contribute to epigenetic regulation in cells? 09/21/2018

DNMT3B plays a crucial role in establishing de novo DNA methylation patterns during embryonic development and cell differentiation, contributing to the epigenetic regulation of gene expression.

What are the therapeutic implications of targeting DNMT3B in cancer treatment? 02/03/2018

Inhibition of DNMT3B activity through targeted therapy or epigenetic modifying agents has been explored as a potential treatment strategy to reverse abnormal DNA methylation patterns and restore normal gene expression in cancer cells.

Customer Reviews (3)

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Reviews
11/09/2020

    The DNMT3B protein is of exceptional quality and has proven to be an ideal choice to meet my experimental requirements.

    09/10/2020

      With its consistent and outstanding results, the DNMT3B protein is an indispensable tool that I highly recommend for researchers in need of reliable and precise protein analysis.

      04/23/2019

        Its purity and reliability have consistently resulted in successful outcomes in my research projects, providing me with accurate and reproducible data.

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