DNMT3B
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Official Full Name
Dnmt3b DNA methyltransferase 3B
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Overview
Dnmt3b (DNA (cytosine-5-)-methyltransferase 3b) has a role in the establishment and regulation of tissue-specific patterns of methylated cytosine residues (epigenetics). Dnmt3b is thought to function in de novo methylation rather than maintenance methylation. The protein localizes primarily to the nucleus and its expression is developmentally regulated. Mutations in this gene cause the immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome. -
Synonyms
DNMT3B; DNA methyltransferase 3B; DNA (cytosine-5)-methyltransferase 3B; m.MmuIIIB; DNA MTase MmuIIIB; DNA methyltransferase MmuIIIB; MGC124407;
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DNMT3B involved in several pathways and played different roles in them. We selected most pathways DNMT3B participated on our site, such as Cysteine and methionine metabolism, DNA methylation, Epigenetic regulation of gene expression, which may be useful for your reference. Also, other proteins which involved in the same pathway with DNMT3B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cysteine and methionine metabolism | MTAP;LDHAL6A;DNMT3B;MDH2;SDSL;MAT2AA;MAT2A;GSS;AHCYL2 |
| DNA methylation | DNMT3L;UHRF1;DNMT1;DNMT3A;DNMT3B |
| Epigenetic regulation of gene expression | SAP30L;CD3EAP;H3F3D;RBB4L;TAF1A;DNMT3B;SUDS3;DNMT1;MTF2 |
| Gene Expression | ZNF496;NRBF2B;TAF1A;ZNF274;LSM11;QTRTD1;ZNF383;HNRNPUL1;SURF1 |
| Metabolic pathways | QDPRB2;MAPK1IP1L;MDH1;NDUFS2;LIPG;EPT1;NDUFS6;ACSL1B;HYAL1 |
| MicroRNAs in cancer | RPS6KA5;SERPINB5;FGFR3;ERBB3;MET;KRAS;MMP16;RDX;DNMT3A |
| Negative epigenetic regulation of rRNA expression | SAP30BP;SUDS3;DNMT1;SIN3B;CD3EAP;SAP18;TAF1D;TAF1A;SAP30L |
| NoRC negatively regulates rRNA expression | CD3EAP;DNMT3B;TAF1B;TAF1A;BAZ2A;TAF1C;TAF1D;DNMT1;SIN3B |
DNMT3B has several biochemical functions, for example, DNA (cytosine-5-)-methyltransferase activity, DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates, DNA-methyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DNMT3B itself. We selected most functions DNMT3B had, and list some proteins which have the same functions with DNMT3B. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| DNA (cytosine-5-)-methyltransferase activity | DNMT1;DNMT3B;DNMT3A;TRDMT1 |
| DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates | DNMT3A;DNMT3B |
| DNA-methyltransferase activity | TRMT10B;PRMT8B;METTL8;RNMTL1A;RNMTL1B;METTL21D;DNMT1;DNMT3AB;MGMT |
| chromatin binding | HDAC7;FEZF2;HDAC2;MTA1;FLI1;NKX2-5;TRP53;HMGXB4A;MBD1 |
| histone deacetylase binding | YWHAB;TOP2B;HDAC3;NRIP1;HIST1H1B;KPNA2;CCND1;SUDS3;SOD3 |
| metal ion binding | ITGA7;PPM1BB;ARL1;ZC2HC1A;NR1D2A;LMO4B;CSRP1B;LOXL2B;DSG1A |
| protein binding | TLN1;CREBZF;GSTA2;ASB6;B2M;ERCC2;BUD31;ACYP2;TMEM139 |
| transcription corepressor activity | TLE2;JUNB;HOMEZB;CITED2;SUFU;YY1;ALX1;TRIM28;HOMEZA |
| unmethylated CpG binding | DNMT3B;DNMT3A;MLL1;CXXC1;KDM2A |
DNMT3B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DNMT3B here. Most of them are supplied by our site. Hope this information will be useful for your research of DNMT3B.
EZH2; EED; SUMO1; UHRF1
Research Area
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Customer Reviews (3)
Write a reviewThe DNMT3B protein is of exceptional quality and has proven to be an ideal choice to meet my experimental requirements.
With its consistent and outstanding results, the DNMT3B protein is an indispensable tool that I highly recommend for researchers in need of reliable and precise protein analysis.
Its purity and reliability have consistently resulted in successful outcomes in my research projects, providing me with accurate and reproducible data.
Q&As (5)
Ask a questionTargeting DNMT3B for therapeutic purposes may lead to off-target effects and unintended changes in DNA methylation, potentially causing adverse effects on normal cellular function and gene expression.
Yes, mutations in the DNMT3B gene are linked to a rare genetic disorder called ICF (Immunodeficiency, Centromeric instability, Facial anomalies) syndrome, characterized by immune system deficiencies, facial abnormalities, and unstable centromeric regions in chromosomes.
Research has shown that alterations in DNMT3B expression or activity can be associated with various types of cancer, making it a potential biomarker for cancer diagnosis, prognosis, and treatment response.
DNMT3B plays a crucial role in establishing de novo DNA methylation patterns during embryonic development and cell differentiation, contributing to the epigenetic regulation of gene expression.
Inhibition of DNMT3B activity through targeted therapy or epigenetic modifying agents has been explored as a potential treatment strategy to reverse abnormal DNA methylation patterns and restore normal gene expression in cancer cells.
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