Recombinant Human ENPP2, His-tagged

• Cat.No.: ENPP2-566H
• Product Overview: Recombinant Human ENPP2 with 6-His tag was expressed inSf9cells and purified using nickel-NTA chromatography.

Specification

• Cat. No.: ENPP2-566H
• Description: The protein encoded by this gene functions as both a phosphodiesterase, which cleaves phosphodiester bonds at the 5" end of oligonucleotides, and a phospholipase, which catalyzes production of lysophosphatidic acid (LPA) in extracellular fluids. LPA evokes growth factor-like responses including stimulation of cell proliferation and chemotaxis. This gene product stimulates the motility of tumor cells and has angiogenic properties, and its expression is upregulated in several kinds of carcinomas. The gene product is secreted and further processed to make the biologically active form. Several alternatively spliced transcript variants encoding different isoforms have been identified.
• Source: Sf9.
• Quality Assay: Silver Stain.
• Specific Activity: 2.86 pmol/min/ng.
• Molecular Weight: 100kDa.

Gene Information

• Gene Name: ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2 [ Homo sapiens ]
• Synonyms: ENPP2; ectonucleotide pyrophosphatase/phosphodiesterase 2; ATX; NPP2; ATX-X; PDNP2; LysoPLD; FLJ26803; AUTOTAXIN; PD-IALPHA; EC 3.1.4.39; E-NPP 2; ectonucleotide pyrophosphatase/phosphodiesterase family member 2; plasma lysophospholipase D; phosphodiesterase I/nucleotide pyrophosphatase 2; extracellular lysophospholipase D
• Gene ID: 5168
• mRNA Refseq: NM_001040092
• Protein Refseq: NP_001035181
• MIM: 601060
• UniProt ID: Q13822
• Chromosome Location: 8q24.1
• Pathway: Ether lipid metabolism
• Function: alkylglycerophosphoethanolamine phosphodiesterase activity; hydrolase activity; metal ion binding; nucleic acid binding; nucleotide diphosphatase activity; polysaccharide binding; scavenger receptor activity; transcription factor binding

Reviews

02/21/2023

Excellent after-sales service, solving many experimental problems.

11/09/2022

Fast and timely shipment helped me to get satisfactory experimental results in short time.

04/01/2022

Customer service promptly feedback my requests, technical staff timely solve the problems that arise.

Q&As

What effects does overexpression of ENPP2 have on HUVEC cells?

Overexpression of ENPP2 promotes proliferation and migration of HUVEC cells.

What biological processes is ENPP2 involved in?

ENPP2 is involved in a variety of physiological processes such as angiogenesis, inflammatory response, and neurodevelopment.

What does ENPP2 have to do with lysophosphatidic acid?

ENPP2 can secrete lysophosphatidic acid.

What parts of the structural domain make up ENPP2?

ENPP2 consists of two N-terminal growth hormone B-like structural domains, a central catalytic phosphodiesterase structural domain and a C-terminal nuclease-like structural domain.

In which organs is ENPP2 expressed?

ENPP2 is expressed in the brain, placenta and ovary.