Recombinant Human AGER Protein (ECD), Fc-His-tagged(C-ter)
Cat.No. : | AGER-05H |
Product Overview : | Recombinant Human AGER Protein (ECD) with Fc-His tag (C-ter) was expressed in HEK293. |
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Description : | The advanced glycosylation end product (AGE) receptor encoded by this gene is a member of the immunoglobulin superfamily of cell surface receptors. It is a multiligand receptor, and besides AGE, interacts with other molecules implicated in homeostasis, development, and inflammation, and certain diseases, such as diabetes and Alzheimer's disease. Many alternatively spliced transcript variants encoding different isoforms, as well as non-protein-coding variants, have been described for this gene (PMID:18089847). [provided by RefSeq, May 2011] |
Source : | HEK293 |
Species : | Human |
Tag : | Fc-His(C-ter) |
Form : | Powder |
Protein Length : | Gln24-Ala344 |
Endotoxin : | Endotoxin level is less than 0.1 EU/μg of the protein, as determined by the LAL test. |
Purity : | > 90% (by SDS-PAGE) |
Applications : | Binding, SDS-PAGE |
Notes : | For laboratory research only, not for drug, diagnostic or other use. |
Storage : | Lyophilized protein should be stored at -20°C or -80°C. After reconstitution, aliquot and store at -20°C for up to one month, at 2-8°C for up to one week. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. |
Storage Buffer : | PBS (pH 7.4) |
Reconstitution : | Reconstitute to a concentration of 0.1-0.5 mg/ml in sterile distilled water. |
Gene Name : | AGER advanced glycosylation end product-specific receptor [ Homo sapiens ] |
Official Symbol : | AGER |
Synonyms : | AGER; advanced glycosylation end product-specific receptor; RAGE; RAGE isoform sRAGE-delta; RAGE isoform NtRAGE-delta; |
Gene ID : | 177 |
mRNA Refseq : | NM_001136 |
Protein Refseq : | NP_001127 |
MIM : | 600214 |
UniProt ID : | Q15109 |
Products Types
◆ Recombinant Protein | ||
Ager-3304M | Recombinant Mouse Ager protein(Met1-Ala342), His-tagged | +Inquiry |
Ager-3M | Recombinant Mouse Ager Protein, His (Fc)-Avi-tagged | +Inquiry |
Ager-2R | Recombinant Rat Ager Protein, His (Fc)-Avi-tagged | +Inquiry |
AGER-1061H | Recombinant Human AGER Protein (Met1-Ala342), HlgG1 Fc-tagged | +Inquiry |
AGER-3137H | Active Recombinant Human AGER protein(Met1-Ala344), hFc-tagged | +Inquiry |
◆ Lysates | ||
AGER-1480HCL | Recombinant Human AGER cell lysate | +Inquiry |
AGER-2546HCL | Recombinant Human RAGE 293 Cell Lysate | +Inquiry |
AGER-2215MCL | Recombinant Mouse AGER cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (20)
Ask a questionAGER is involved in bone metabolism and might influence osteoporosis and bone diseases.
AGER levels might serve as biomarkers for certain diseases, including diabetes.
AGER binds AGEs, initiating signaling cascades linked to inflammation, oxidative stress, and tissue damage.
AGER contributes to skin aging through oxidative stress and collagen damage.
AGER stands for "Advanced Glycosylation End-Product Specific Receptor," a cell surface receptor.
Yes, AGER activation contributes to inflammation and immune responses.
AGER activation can impair wound healing through inflammation and oxidative stress.
AGER contributes to neuroinflammation and might play a role in neurodegeneration.
AGER contributes to diabetic nephropathy and kidney dysfunction.
AGER binds to AGEs, initiating cellular signaling pathways linked to inflammation and oxidative stress.
AGER is implicated in lung diseases and inflammation, such as chronic obstructive pulmonary disease.
Researchers explore compounds that modulate AGER to mitigate its effects.
AGER contributes to diabetic complications by promoting inflammation and tissue damage.
AGER is studied for its implications in aging, diabetes, and various age-related diseases.
AGER plays a role in mediating cellular responses to advanced glycation end products (AGEs).
Consuming a low-AGE diet may help reduce AGER activation and its negative effects.
AGER activation affects immune cell functions and influences immune responses.
AGER activation is linked to cardiovascular diseases, including atherosclerosis.
Yes, besides AGEs, AGER interacts with other ligands like HMGB1 and β-amyloid.
Yes, ongoing research aims to uncover new roles and therapeutic targets related to AGER.
Customer Reviews (5)
Write a reviewIt's quality was evident in consistent results across replicates.
Protein consistently upregulated the expression of tissue-specific markers.
Gel electrophoresis bands displayed distinct separation, showcasing the product’s purity.
It’s consistent outcomes supported reliable statistical analysis.
Consistency and Compatibility Consistency in the product’s performance bolstered the credibility of our research findings.
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