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AGER

  • Official Full Name

    advanced glycosylation end product-specific receptor

  • Overview

    The advanced glycosylation end product (AGE) receptor encoded by this gene is a member of the immunoglobulin superfamily of cell surface receptors. It is a multiligand receptor, and besides AGE, interacts with other molecules implicated in homeostasis, development, and inflammation, and certain diseases, such as diabetes and Alzheimers disease. Many alternatively spliced transcript variants encoding different isoforms, as well as non-protein-coding variants, have been described for this gene (PMID:18089847). [provided by RefSeq, May 2011]
  • Synonyms

    AGER; advanced glycosylation end product-specific receptor; RAGE; RAGE isoform sRAGE-delta; RAGE isoform NtRAGE-delta; receptor for advanced glycation end-products variant 20;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Canine
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • E.coli
  • HEK293
  • Human Cell
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • C
  • hFc
  • His
  • Fc
  • His(C
  • ter)
  • Flag
  • GST
  • His (Fc)
  • Avi
  • His|Flag|StrepII
  • His|GST
  • His|T7
  • HlgG1 Fc
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human AGER-328H Active Recombinant Human AGER Protein HEK293 N/A
Human AGER-7323H Recombinant Human AGER protein HEK293 N/A Met1-Ala344
Human AGER-423H Recombinant Human AGER Protein, GST-tagged Wheat Germ GST
Human AGER-7322H Active Recombinant Human AGER protein, His-tagged HEK293 His Met1-Ala344
Human AGER-421P Recombinant Human AGER Protein, His-Flag-StrepII-tagged HEK293 His/Flag/StrepII
Human AGER-3648H Recombinant Human AGER, His-tagged E.coli His
Human AGER-917H Recombinant Human AGER, His-tagged E.coli His
Human AGER-3137H Active Recombinant Human AGER protein(Met1-Ala344), hFc-tagged HEK293 C-hFc Met1-Ala344
Human AGER-3649H Recombinant Human AGER, Flag-tagged HEK293 Flag
Human AGER-9468H Recombinant Human AGER, GST-tagged E.coli GST 26-340a.a.
Human RAGE-2163H Recombinant Human RAGE protein, GST-tagged E.coli GST 1-231aa
Human AGER-2546HCL Recombinant Human RAGE 293 Cell Lysate HEK293 N/A
Human AGER-1480HCL Recombinant Human AGER cell lysate Human Cell N/A
Human AGER-1061H Recombinant Human AGER Protein (Met1-Ala342), HlgG1 Fc-tagged HEK293 HlgG1 Fc Met1-Ala342
Human AGER-3706H Recombinant Human AGER protein, His-tagged E.coli His 26-340 aa
Human AGER-0449H Recombinant Human AGER Protein (Ala23-Ala344), C-His-tagged Mammalian cells C-His Ala23-Ala344
Human AGER-0451H Recombinant Human AGER Protein (Ile91-Asp274), N-His-tagged E.coli N-His Ile91-Asp274
Human AGER-70H Recombinant Human AGER Protein (Aal23-Ser120), C-His tagged, Animal-free, Carrier-free E.coli C-His Aal23-Ser120
Human AGER-2676H Active Recombinant Human AGER protein, hFc&His-tagged HEK293 hFc&His Gln24-Ala344
Human AGER-05H Recombinant Human AGER Protein (ECD), Fc-His-tagged(C-ter) HEK293 Fc-His(C-ter) Gln24-Ala344
Human AGER-833H Recombinant Human AGER Protein, Fc-tagged HEK293 Fc 404
Mouse Ager-958M Active Recombinant Mouse Ager Protein, Fc Chimera Mammalian cells Fc
Mouse Ager-653M Recombinant Mouse Ager protein, His & T7-tagged E.coli His/T7 Trp10~Arg188 (Accession # Q62151)
Mouse Ager-3304M Recombinant Mouse Ager, His tagged Human Cell His
Mouse AGER-2215MCL Recombinant Mouse AGER cell lysate Human Cell N/A
Mouse Ager-712M Recombinant Mouse Ager Protein, His-tagged E.coli His Lys2~Lys228
Mouse Ager-3M Recombinant Mouse Ager Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Ager-3M-B Recombinant Mouse Ager Protein Pre-coupled Magnetic Beads HEK293
Rat Ager-540R Active Recombinant Rat Advanced Glycosylation End Product-Specific Receptor, Fc-tagged Mammalian cells Fc
Rat Ager-654R Recombinant Rat Ager protein, His & T7-tagged E.coli His/T7 Pro180~Pro402 (Accession# Q63495)
Rat Ager-2R-B Recombinant Rat Ager Protein Pre-coupled Magnetic Beads HEK293
Rat Ager-713R Recombinant Rat Ager Protein, His/GST-tagged E.coli His/GST Met1~Tyr237
Rat Ager-2R Recombinant Rat Ager Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Canine AGER-537C Active Recombinant Canine Advanced Glycosylation End Product-Specific Receptor, His-tagged Mammalian cells His
Canine AGER-424C Active Recombinant Canine AGER, His-tagged Mammalian cells His
Canine AGER-2C Recombinant Canine AGER Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Canine AGER-2C-B Recombinant Canine AGER Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque AGER-268R Recombinant Rhesus monkey AGER Protein, His-tagged Mammalian Cell His
Rhesus Macaque AGER-96R-B Recombinant Rhesus Macaque AGER Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque AGER-96R Recombinant Rhesus Macaque AGER Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • AGER Related Articles

AGER involved in several pathways and played different roles in them. We selected most pathways AGER participated on our site, such as AGE/RAGE pathway, Activated TLR4 signalling, Advanced glycosylation endproduct receptor signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with AGER were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
AGE/RAGE pathwayMMP13;JUN;EGFR;DIAPH1;MAPK14;LGALS3;ATF2;AGER;TIRAP
Activated TLR4 signallingATF2;TLR6;CHUK;CHST13;PELI3;CREB1B;DHX9;IRAK3;NOD1
Advanced glycosylation endproduct receptor signalingLGALS3;S100A12;AGER;ALCAMB;SAA1;S100B;APPA;DDOST;APPB
Cytosolic sensors of pathogen-associated DNAPOLR3F;POLR3GLA;S100A12;RIPK3;NLRP4C;AGER;MB21D1;SAA1;DDX41
DEx/H-box helicases activate type I IFN and inflammatory cytokines productionAPPA;AGER;SAA1;APPB;ALCAMB;DHX9;S100A12;CHST13;S100B
Immune SystemCD160;DDX41;NCR3LG1;TCIRG1;PANX1;CSH1;OASL;DYNC1H1;LILRB2
Innate Immune SystemNOD1;MAP3K8;DEFB1;ABI1B;TRIM56;SIRPB1;DEFB125;ART1;CFHL3
MyD88 cascade initiated on plasma membranePELI1;PELI3;DUSP3B;PELI2;ALCAMB;S100A12;S100B;TNIP2;DHX9

AGER has several biochemical functions, for example, S100 protein binding, advanced glycation end-product receptor activity, high mobility group box 1 binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AGER itself. We selected most functions AGER had, and list some proteins which have the same functions with AGER. You can find most of the proteins on our site.

Function Related Protein
S100 protein bindingAGER;S100A11;S100A1;FGF1;ANXA2;AHNAK;ANXA11;S100A6;S100B
advanced glycation end-product receptor activity
high mobility group box 1 binding
identical protein bindingCCL4;CBY1;S100A2;VPS41;ASMT;SLIT2;STAT2;EIF2AK3;DVL1
protein bindingUFD1L;Fert2;SRI;AZIN1;C3;USO1;MED7;MEMO1;MAGEA11
receptor activityLILRA3;OR3A2;Tnfrsf22;DARC;CD7;CSF2RA;ADCYAP1R1;SLC1A5;TNFRSF9
transmembrane signaling receptor activityANTXR1;TLR7;M6PR;SPN;FZD9B;CD300C;ERBB2;RYK;DARC

AGER has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AGER here. Most of them are supplied by our site. Hope this information will be useful for your research of AGER.

S100B; DIAPH1; TTR; GRB2; Diaph1; HMGB1; S100A1

Lindskog, C; Fagerberg, L; et al. The lung-specific proteome defined by integration of transcriptomics and antibody-based profiling. FASEB JOURNAL 28:5184-5196(2014).
Potzsch, S; Blankenhorn, A; et al. The effect of an AGE-rich dietary extract on the activation of NF-kappa B depends on the cell model used. FOOD & FUNCTION 4:1023-1031(2013).
  • Q&As
  • Reviews

Q&As (20)

Ask a question
How does AGER affect bone health? 09/02/2022

AGER is involved in bone metabolism and might influence osteoporosis and bone diseases.

Are there diagnostic applications for AGER? 08/10/2022

AGER levels might serve as biomarkers for certain diseases, including diabetes.

How does AGER interact with AGEs? 07/05/2022

AGER binds AGEs, initiating signaling cascades linked to inflammation, oxidative stress, and tissue damage.

How is AGER implicated in skin aging? 05/30/2022

AGER contributes to skin aging through oxidative stress and collagen damage.

What is the AGER protein? 07/15/2021

AGER stands for "Advanced Glycosylation End-Product Specific Receptor," a cell surface receptor.

Can the AGER protein impact inflammation? 07/15/2021

Yes, AGER activation contributes to inflammation and immune responses.

How does AGER impact wound healing? 02/05/2021

AGER activation can impair wound healing through inflammation and oxidative stress.

How does AGER influence neurodegenerative diseases? 01/22/2021

AGER contributes to neuroinflammation and might play a role in neurodegeneration.

Can AGER influence kidney function? 12/06/2020

AGER contributes to diabetic nephropathy and kidney dysfunction.

How does the AGER protein interact with AGEs? 09/23/2020

AGER binds to AGEs, initiating cellular signaling pathways linked to inflammation and oxidative stress.

Can AGER influence lung health? 01/31/2020

AGER is implicated in lung diseases and inflammation, such as chronic obstructive pulmonary disease.

Are there therapeutic strategies targeting AGER? 06/09/2019

Researchers explore compounds that modulate AGER to mitigate its effects.

How is AGER involved in diabetic complications? 05/13/2019

AGER contributes to diabetic complications by promoting inflammation and tissue damage.

How is the AGER protein involved in research? 01/28/2019

AGER is studied for its implications in aging, diabetes, and various age-related diseases.

What is the function of the AGER protein? 07/25/2018

AGER plays a role in mediating cellular responses to advanced glycation end products (AGEs).

Are there dietary interventions for AGER-related effects? 10/05/2017

Consuming a low-AGE diet may help reduce AGER activation and its negative effects.

Can AGER impact immune responses? 06/29/2017

AGER activation affects immune cell functions and influences immune responses.

Does AGER affect cardiovascular health? 12/04/2016

AGER activation is linked to cardiovascular diseases, including atherosclerosis.

Are there other ligands for the AGER protein? 11/25/2016

Yes, besides AGEs, AGER interacts with other ligands like HMGB1 and β-amyloid.

Is AGER research ongoing? 11/02/2016

Yes, ongoing research aims to uncover new roles and therapeutic targets related to AGER.

Customer Reviews (5)

Write a review
Reviews
02/26/2022

    It's quality was evident in consistent results across replicates.

    08/13/2021

       Protein consistently upregulated the expression of tissue-specific markers.

      01/20/2020

         Gel electrophoresis bands displayed distinct separation, showcasing the product’s purity.

        06/22/2019

          It’s consistent outcomes supported reliable statistical analysis.

          01/11/2017

            Consistency and Compatibility Consistency in the product’s performance bolstered the credibility of our research findings.

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