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  • Official Full Name
  • advanced glycosylation end product-specific receptor
  • Background
  • The advanced glycosylation end product (AGE) receptor encoded by this gene is a member of the immunoglobulin superfamily of cell surface receptors. It is a multiligand receptor, and besides AGE, interacts with other molecules implicated in homeostasis, development, and inflammation, and certain diseases, such as diabetes and Alzheimers disease. Many alternatively spliced transcript variants encoding different isoforms, as well as non-protein-coding variants, have been described for this gene (PMID:18089847). [provided by RefSeq, May 2011]
  • Synonyms
  • AGER; advanced glycosylation end product-specific receptor; RAGE; RAGE isoform sRAGE-delta; RAGE isoform NtRAGE-delta; receptor for advanced glycation end-products variant 20;
Cat.#:Ager-712MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Ager Protein, His-tagged
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Cat.#:Ager-713RTag:His/GST
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Ager Protein, His/GST-tagged
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Cat.#:Ager-540RTag:Fc
Source (Host):NS0Species:Rat
Product nameRecombinant Rat Advanced Glycosylation End Product-Specific Receptor, Fc-tagged
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Cat.#:AGER-537CTag:His
Source (Host):NS0Species:Canine
Product nameRecombinant Canine Advanced Glycosylation End Product-Specific Receptor, His-tagged
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Cat.#:AGER-3137HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human AGER, Fc tagged
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Cat.#:AGER-328HTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human AGER Protein
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Cat.#:AGER-3648HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human AGER, His-tagged
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Cat.#:AGER-3649HTag:Flag
Source (Host):HEK293Species:Human
Product nameRecombinant Human AGER, Flag-tagged
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Cat.#:AGER-421PTag:His-Flag-StrepII
Source (Host):HEK293 cellSpecies:Human
Product nameRecombinant Human AGER Protein, His-Flag-StrepII-tagged
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Cat.#:AGER-423HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human AGER Protein, GST-tagged
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Cat.#:AGER-7322HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human AGER, His tagged
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Cat.#:AGER-7323HTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human AGER, None tagged
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Cat.#:AGER-917HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human AGER, His-tagged
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Cat.#:AGER-9468HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human AGER, GST-tagged
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Cat.#:RAGE-2163HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RAGE protein, GST-tagged
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Cat.#:Ager-3304MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Ager, His tagged
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Cat.#:Ager-653MTag:His/T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Ager protein, His & T7-tagged
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Cat.#:Ager-958MTag:Fc
Source (Host):NSO CellsSpecies:Mouse
Product nameRecombinant Mouse Ager Protein, Fc Chimera
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Cat.#:Ager-654RTag:His/T7
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Ager protein, His & T7-tagged
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Cat.#:AGER-268RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey AGER Protein, His-tagged
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Cat.#:AGER-424CTag:His
Source (Host):NSO cellsSpecies:Canine
Product nameRecombinant Canine AGER, His-tagged
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Cat.#:AGER-1480HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human AGER cell lysate
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Cat.#:AGER-2546HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human RAGE 293 Cell Lysate
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Cat.#:AGER-2215MCLTag:
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse AGER cell lysate
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Involved Pathway

AGER involved in several pathways and played different roles in them. We selected most pathways AGER participated on our site, such as AGE/RAGE pathway, Activated TLR4 signalling, Advanced glycosylation endproduct receptor signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with AGER were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
AGE/RAGE pathway
TIRAP; JAK2; EGFR; DDOST; MAPK14; DIAPH1; JUN; AGER; CHUK; MMP13
Activated TLR4 signalling
TLR6; DUSP7; CHST13; S100B; CREB1; UBE2V1; S100A12; MAPK14; APPA; DUSP6
Advanced glycosylation endproduct receptor signaling
APPB; APPA; AGER; DDOST; LGALS3; S100A12; S100B; ALCAMB; SAA1
Cytosolic sensors of pathogen-associated DNA
POLR3G; POLR3GLA; ALCAMB; POLR3F; POLR3H; DHX9; CRCP; CHST13; DDX41; MB21D1
DEx/H-box helicases activate type I IFN and inflammatory cytokines production
ALCAMB; SAA1; S100B; APPB; AGER; S100A12; CHST13; APPA; DHX9
Immune System
SIGLEC7; ASB6; XAF1; BTR29; IRF9; PVRL2L; ASB8; CD207; KIF26A; TXNIPA
Innate Immune System
DEFA3; SIGLEC15; TRIM56; LRRFIP1; ABI1B; LY86; FAM49BA; PLD4; TLR10; PANX1A
MyD88 cascade initiated on plasma membrane
DHX9; TLR10; ALCAMB; PELI3; AGER; PELI2; PELI1; TNIP2; DUSP3B; CHST13

Protein Function

AGER has several biochemical functions, for example, S100 protein binding, advanced glycation end-product receptor activity, high mobility group box 1 binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AGER itself. We selected most functions AGER had, and list some proteins which have the same functions with AGER. You can find most of the proteins on our site.
Function
Related Protein
Function S100 protein binding
Related Protein S100B; ATP2A2; FGF1A; ANXA11; S100A6; AHNAK; EZR; S100A1; S100A11; ANXA2
Function advanced glycation end-product receptor activity
Related Protein AGER
Function high mobility group box 1 binding
Related Protein AGER
Function identical protein binding
Related Protein TPD52L1; ZNF3; CCL3; THBS1; IRF3; VPS41; TRIP13; LYZ2; AMELX; EED
Function protein binding
Related Protein C5orf30; RALGAPA1; KCNJ10; IL28RA; ZCCHC12; CDKN1A; JIP1; IL24; TAF12; CDH5
Function receptor activity
Related Protein PROCR; TNFRSF11A; GFRA2A; TNFRSF10A; ATP6AP2; ITGB8; GP6; SLC40A1; P2RY11; CD2
Function transmembrane signaling receptor activity
Related Protein SORL1; CD5; M6PR; LGR4; CD69; TNFRSF8; CD300C; ERBB3; CLDN3; CD4

Interacting Protein

AGER has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AGER here. Most of them are supplied by our site. Hope this information will be useful for your research of AGER.
S100B; DIAPH1; TTR; GRB2; Diaph1; HMGB1; S100A1

AGER Related Articles

Lindskog, C; Fagerberg, L; et al. The lung-specific proteome defined by integration of transcriptomics and antibody-based profiling. FASEB JOURNAL 28:5184-5196(2014).
Potzsch, S; Blankenhorn, A; et al. The effect of an AGE-rich dietary extract on the activation of NF-kappa B depends on the cell model used. FOOD & FUNCTION 4:1023-1031(2013).