Recombinant Human EHMT1(951-1235) Protein

• Cat.No.: EHMT1-64H
• Product Overview: Recombinant human EHMT1, amino acids 951-1235, expressed in E.coli. Purified using immobilised metal affinity chromatography

Specification

• Description: EHMT1 (euchromatic histone-lysine N-methyltransferase 1) is an epigenetic protein that functions as a histone methyltransferase. It is responsible for adding methyl groups to specific lysine residues on histone H3, leading to the formation of heterochromatin and gene silencing. EHMT1 is widely expressed in many tissues and is important for normal development and cellular function. Mutations in the EHMT1 gene have been associated with a rare genetic disorder called Kleefstra syndrome, which is characterized by intellectual disability, speech delay, and facial abnormalities. EHMT1 has also been implicated in various diseases, including cancer, neurological disorders, and immunological disorders. Its inhibitors are currently being developed for therapeutic purposes. EHMT1 is a promising target for the treatment of several diseases, and understanding its function is important for developing new therapies.
• Source: E. coli
• Species: Human
• Protein length: 951-1235 aa
• Form: 1mg/ml of enzyme in 5mM Tris/HCl pH7.4, 250mM NaCl, 50% Glycérol. Frozen solution.
• Molecular Mass: 32.9 kDa
• AA Sequence: 1 GSNSQVWSAL QMSKALQDSA PDRPSPVERI VSRDIARGYE RIPIPCVNAV 51 DSEPCPSNYK YVSQNCVTSP MNIDRNITHL QYCVCIDDCS SSNCMCGQLS 101 MRCWYDKDGR LLPEFNMAEP PLIFECNHAC SCWRNCRNRV VQNGLRARLQ 151 LYRTRDMGWG VRSLQDIPPG TFVCEYVGEL ISDSEADVRE EDSYLFDLDN 201 KDGEVYCIDA RFYGNVSRFI NHHCEPNLVP VRVFMAHQDL RFPRIAFFST 251 RLIEAGEQLG FDYGERFWDI KGKLFSCRCG SPKCRHS
• Applications: Drug Discovery & Development
• Storage: 1 year at -70 centigrade.
• Handling Advice: Rapidly thaw the vial under cold water and immediately place on ice. Aliquot unused material into prechilled micro-centrifuge tubes and immediately snap-freeze the vials in liquid nitrogen prior to re-storage at -70 centigrade.
• Use/Stability: On receipt of material store at -70 centigrade. Unopened reagent is stable for a minimum of 1 year from date of shipment when stored at recommended storage temperature. Avoid repeat freeze/thaw cycles. For maximum recovery of product, centrifuge original vial prior to removing the cap.

Gene Information

• Gene Name: EHMT1 euchromatic histone lysine methyltransferase 1 [ Homo sapiens (human) ]
• Official Symbol: EHMT1
• Synonyms: EHMT1; euchromatic histone lysine methyltransferase 1; GLP; GLP1; KMT1D; KLEFS1; FP13812; EHMT1-IT1; EUHMTASE1; Eu-HMTase1
• Gene ID: 79813
• mRNA Refseq: NM_001145527.2
• Protein Refseq: NP_001138999.1
• MIM: 607001
• UniProt ID: Q9H9B1