Recombinant Human FMO3 Protein, MYC/DDK-tagged

• Cat.No.: FMO3-857H
• Product Overview: Recombinant Human FMO3, transcript variant 1, fused with MYC/DDK tag at C-terminal was expressed in HEK293.

Specification

• Description: Flavin-containing monooxygenases (FMO) are an important class of drug-metabolizing enzymes that catalyze the NADPH-dependent oxygenation of various nitrogen-,sulfur-, and phosphorous-containing xenobiotics such as therapeutic drugs, dietary compounds, pesticides, and other foreign compounds. The human FMO gene family is composed of 5 genes and multiple pseudogenes. FMO members have distinct developmental- and tissue-specific expression patterns. The expression of this FMO3 gene, the major FMO expressed in adult liver, can vary up to 20-fold between individuals. This inter-individual variation in FMO3 expression levels is likely to have significant effects on the rate at which xenobiotics are metabolised and, therefore, is of considerable interest to the pharmaceutical industry. This transmembrane protein localizes to the endoplasmic reticulum of many tissues. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. Mutations in this gene cause the disorder trimethylaminuria (TMAu) which is characterized by the accumulation and excretion of unmetabolized trimethylamine and a distinctive body odor. In healthy individuals, trimethylamine is primarily converted to the non odorous trimethylamine N-oxide.
• Source: HEK293
• Species: Human
• Tag: MYC/DDK
• Form: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 59.9 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: >50 ug/mL as determined by microplate BCA method

Gene Information

• Gene Name: FMO3 flavin containing monooxygenase 3 [ Homo sapiens ]
• Official Symbol: FMO3
• Synonyms: FMO3; flavin containing monooxygenase 3; dimethylaniline monooxygenase [N-oxide-forming] 3; FMO 3; FMO II; FMO form 2; dimethylaniline oxidase 3; hepatic flavin-containing monooxygenase 3; hepatic flavin-containing monooxygenase-3; TMAU; FMOII; dJ127D3.1; MGC34400
• Gene ID: 2328
• mRNA Refseq: NM_006894
• Protein Refseq: NP_008825
• MIM: 136132
• UniProt ID: P31513

Reviews

07/19/2022

It is easy to operate, and it does not take too long to learn Xi to operate, saving time.

05/09/2020

The FMO3 they produce is of high purity and the experimental results are accurate.

03/08/2020

It is suitable for novices and has low technical and environmental requirements.

Q&As

Are there factors that influence FMO3 activity?

The activity of FMO3 is affected by a variety of factors, including genetic factors, dietary factors, environmental factors, etc.

What role does FMO3 play in cancer?

It plays an important role in cancer, and it can affect the occurrence and progression of cancer by regulating the metabolism of some carcinogens.

Why is FMO3 related to neurological diseases?

FMO3 is also associated with neurological diseases, and studies have shown that FMO3 can regulate the metabolism of neurotransmitters and affect the function of the nervous system.

What is the association between FMO3 and cardiovascular disease?

This protein is also associated with cardiovascular disease, and studies have shown that FMO3 can regulate cholesterol metabolism and affect the development of cardiovascular disease.

Is there a genetic variant in FMO3?

Yes, there are genetic variants in FMO3 that can affect FMO3 activity and expression levels.

How to regulate the activity of FMO3?

FMO3 activity can be regulated by changing dietary Xi, increasing exercise, and regulating antioxidants in the diet.