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FMO5

  • Official Full Name

    flavin containing monooxygenase 5

  • Overview

    Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man resulting in a small subpopulation with reduced TMA N-oxidation capacity resulting in fish odor syndrome Trimethylaminuria. Three forms of the enzyme, FMO1 found in fetal liver, FMO2 found in adult liver, and FMO3 are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics. Alternative splicing results in multiple transcript variants.
  • Synonyms

    FMO5; flavin containing monooxygenase 5; dimethylaniline monooxygenase [N-oxide-forming] 5; Dimethylaniline monooxygenase [N oxide forming] 5; Dimethylaniline oxidase 5; FMO 5; Hepatic flavin containing monooxygenase 5; OTTHUMP00000016306; OTTHUMP00000016307; OTTHUMP00000231953; OTTHUMP00000231954; hepatic flavin-containing monooxygenase 5;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Insect Cell
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human FMO5-12946H Recombinant Human FMO5, His-tagged E.coli His 34-285a.a.
Human FMO5-717H Recombinant Human Flavin Containing Monooxygenase 5 Insect Cell N/A
Human FMO5-6181HCL Recombinant Human FMO5 293 Cell Lysate HEK293 N/A
Human FMO5-2397H Recombinant Human FMO5 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human FMO5-4394H Recombinant Human FMO5 Protein, GST-tagged Wheat Germ GST
Human FMO5-4992HF Recombinant Full Length Human FMO5 Protein, GST-tagged In Vitro Cell Free System GST 285 amino acids
Mouse FMO5-5941M Recombinant Mouse FMO5 Protein Mammalian Cell His
Mouse FMO5-3293M-B Recombinant Mouse FMO5 Protein Pre-coupled Magnetic Beads HEK293
Mouse Fmo5-3056M Recombinant Mouse Fmo5 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse FMO5-3293M Recombinant Mouse FMO5 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat FMO5-2370R Recombinant Rat FMO5 Protein Mammalian Cell His
Rat FMO5-2026R-B Recombinant Rat FMO5 Protein Pre-coupled Magnetic Beads HEK293
Rat FMO5-2026R Recombinant Rat FMO5 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish FMO5-9870Z Recombinant Zebrafish FMO5 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • FMO5 Related Articles

FMO5 involved in several pathways and played different roles in them. We selected most pathways FMO5 participated on our site, such as Drug metabolism - cytochrome P, which may be useful for your reference. Also, other proteins which involved in the same pathway with FMO5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Drug metabolism - cytochrome PALDH3B1;UGT2A3;FMO4;GSTP1;ALDH1A3;AOX3;GSTM6;AOX4;GSTA

FMO5 has several biochemical functions, for example, N,N-dimethylaniline monooxygenase activity, NADP binding, flavin adenine dinucleotide binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FMO5 itself. We selected most functions FMO5 had, and list some proteins which have the same functions with FMO5. You can find most of the proteins on our site.

Function Related Protein
N,N-dimethylaniline monooxygenase activityFMO5;FMO1;FMO3;FMO2
NADP bindingHMGCRA;NOS3;CRYM;GAPDHS;GSR;FMO3;MIOX;PGD;NOS1
flavin adenine dinucleotide bindingCYB5R3;ACADL;D2HGDH;NOS3;KDM1B;AOX3L1;KMO;FMO5;ACADVL

FMO5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FMO5 here. Most of them are supplied by our site. Hope this information will be useful for your research of FMO5.

Shalaby, EM; Girgis, AS; et al. Regioselective synthesis, stereochemical structure, spectroscopic characterization and geometry optimization of dispiro[3H-indole-3, 2 '-pyrrolidine-3 ',3 ''-piperidines]. JOURNAL OF MOLECULAR STRUCTURE 1075:327-334(2014).
Xie, G; Cheng, KW; et al. The in vitro metabolism of phospho-sulindac amide, a novel potential anticancer agent. BIOCHEMICAL PHARMACOLOGY 91:249-255(2014).
  • Q&As
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