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Active Recombinant Human TGFB3 Protein

Cat.No. : TGFB3-105H
Product Overview : The mature recombinant human TGF-beta 3 protein consists of 112 amino acids (301-412) without tag was expressed in E. coli.
  • Specification
  • Gene Information
  • Related Products
Description : This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGF-beta family members. This protein is involved in embryogenesis and cell differentiation, and may play a role in wound healing. Mutations in this gene are a cause of aortic aneurysms and dissections, as well as familial arrhythmogenic right ventricular dysplasia 1.
Source : E. coli
Species : Human
Bio-activity : Measured by its ability to inhibit the IL-4-dependent proliferation of HT-2 mouse T cells. The ED50 for this effect is 0.01-0.04 ng/mL.
Molecular Mass : 12.7 kDa
Product-Related Proteins : 301-412
Storage : At -80 centigrade. Avoid repeated freeze-thaw cycles.
Storage Buffer : PBS
Gene Name : TGFB3 transforming growth factor beta 3 [ Homo sapiens (human) ]
Official Symbol : TGFB3
Synonyms : TGFB3; transforming growth factor beta 3; ARVD; LDS5; RNHF; ARVD1; TGF-beta3; transforming growth factor beta-3 proprotein; prepro-transforming growth factor beta-3
Gene ID : 7043
mRNA Refseq : NM_003239
Protein Refseq : NP_003230
MIM : 190230
UniProt ID : P10600

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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