Recombinant Human SMYD2, GST-tagged
Cat.No. : | SMYD2-6967H |
Product Overview : | Recombinant full-length human SMYD2 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. |
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Description : | SMYD2 (also known as SET and MYND domain-containing protein 2) is a member of the SMYD family of protein methyltransferases. SMYD2 is also known as lysine methyltransferase protein 3C (KMT3C). SMYD2 functions to repress transcription by interacting with the Sin3A histone deacetylase complex and performs methylation of Lys36 in histone H3. The exogenous expression of SMYD2 in mouse fibroblasts decreases cell growth. SMYD2 also function as a putative oncogene by methylating p53 and repressing its tumor suppressive function. |
Source : | Sf9 Cells |
Species : | Human |
Tag : | GST |
Form : | Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol. |
Molecular Mass : | ~70 kDa |
Protein length : | Full length |
Purity : | >85% |
Applications : | Western Blot |
Storage : | Store at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. Avoid freeze/thaw cycles. |
Concentration : | 0.1 μg/μ |
Gene Name : | SMYD2 SET and MYND domain containing 2 [ Homo sapiens ] |
Official Symbol : | SMYD2 |
Synonyms : | SMYD2; SET and MYND domain containing 2; N-lysine methyltransferase SMYD2; HSKM B; KMT3C; ZMYND14; lysine N-methyltransferase 3C; histone methyltransferase SMYD2; zinc finger, MYND domain containing 14; SET and MYND domain-containing protein 2; HSKM-B; MGC119305; |
Gene ID : | 56950 |
mRNA Refseq : | NM_020197 |
Protein Refseq : | NP_064582 |
MIM : | 610663 |
UniProt ID : | Q9NRG4 |
Chromosome Location : | 1q32.3 |
Pathway : | p53 pathway, organism-specific biosystem; |
Function : | RNA polymerase II core binding; histone methyltransferase activity (H3-K36 specific); metal ion binding; methyltransferase activity; p53 binding; protein binding; protein-lysine N-methyltransferase activity; transferase activity; zinc ion binding; |
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SMYD2-2063H | Recombinant Human SMYD2 Protein, MYC/DDK-tagged | +Inquiry |
SMYD2-8507M | Recombinant Mouse SMYD2 Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
SMYD2-705HCL | Recombinant Human SMYD2 cell lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionInvestigations into small molecules and inhibitors targeting SMYD2 are underway, with potential applications in cancer and cardiovascular disease treatment.
Monitoring SMYD2 levels may provide insights into the progression of cardiovascular diseases, aiding in early diagnosis and treatment.
Research suggests that SMYD2 may play a role in neurodegenerative diseases, and exploring its modulation could offer new avenues for therapeutic intervention.
SMYD2 is involved in various cellular processes, including cell cycle regulation, DNA repair, and inflammation, making it a versatile protein with potential implications in multiple diseases.
SMYD2 has been linked to cardiac hypertrophy and heart failure, suggesting its potential as a therapeutic target in the context of cardiovascular diseases.
Customer Reviews (3)
Write a reviewIts compatibility with various methodologies further enhances its value as a research tool, making it a go-to choice for investigating SMYD2 protein function and molecular interactions.
The versatility of the SMYD2 protein extends beyond these applications, enabling its use in a wide range of experimental techniques.
the SMYD2 protein stands out for its exceptional quality and its ability to fulfill my experimental requirements.
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