Recombinant Mouse Calbindin 2

• Cat.No.: Calb2-4911M
• Product Overview: Recombinant Murine Calb2 protein is expressed from E. coli and purified by proprietary chromatographic techniques.

Specification

• Cat. No.: Calb2-4911M
• Description: Calb2 is an intraCellular calcium-binding protein belonging to the troponin C superfamily characterized by a structural motif described as the EF-hand domain. The immunohistochemical detection of Calb2 in developing cerebellum is restricted to the later stages indicated by weak staining from week 21 of gestation, in Purkinje and basket cells and in neurons of the dentate nucleus. The intensity of staining increases as the cerebellum matures. In tumors, Calb2 has been detected in mesotheliomas and some pulmonary adenocarcinomas.
• Molecular Weight: 57 kDa
• Source: E. coli
• Species: Human
• Form: 50μl(100μg/ml)in 50 mM Tris-Acetate,pH 7.5,1 mM EDTA,20%Glycerol.
• Appearance: Liquid
• Endotoxin Level: <0.1 ng/μg
• Purity: ≥90% by SDS-PAGE and HPLC analyses
• Storage: Store at -20°C to -20°C. Stable for 6-12 months.Avoid freeze-thaw cycles.

Gene Information

• Gene Name: Calb2 calbindin 2 [ Mus musculus ]
• Official Symbol: Calb2
• Synonyms: Calb2; calbindin 2; CR; calretinin; Calretinin
• Gene ID: 12308
• mRNA Refseq: NM_007586
• Protein Refseq: NP_031612
• UniProt ID: Q08331
• Chromosome Location: 8 E1
• Function: calcium ion binding

Reviews

10/19/2021

High-quality recombinant proteins boost research productivity.

06/13/2019

Ease of use makes them ideal for both novice and expert researchers.

07/07/2018

They are essential components of our lab toolkit.

Q&As

Are there any therapeutic strategies targeting CALB2 for neurological conditions?

While there are no specific drugs targeting CALB2, research into calcium homeostasis modulation and CALB2's role in disease may lead to potential therapeutic avenues.

What is the role of CALB2 in the maintenance of neuronal calcium gradients across subcellular compartments, and how does this impact cellular function?

CALB2 helps establish and maintain calcium gradients within neurons, ensuring proper functioning of processes such as neurotransmission, dendritic integration, and synaptic plasticity by fine-tuning local calcium concentrations.

How does CALB2 contribute to calcium-dependent gene regulation within neurons at the molecular level?

CALB2 can interact with transcription factors and co-factors involved in calcium-dependent gene expression, influencing the activation or repression of specific genes in response to changes in intracellular calcium levels.

How does CALB2 function in balancing calcium levels during neuronal activity and synaptic transmission at the molecular level?

CALB2 dynamically binds and releases calcium ions in response to changes in intracellular calcium concentration, fine-tuning calcium signaling during neuronal activity and synaptic transmission.

In which specific neuronal cell types and brain regions is CALB2 highly expressed?

CALB2 is abundantly expressed in various neuronal populations, including cerebellar granule cells, interneurons in the cortex, and certain subtypes of neurons in the hippocampus.