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Recombinant Human CALB2 Protein, GST-Tagged

Cat.No. : CALB2-0287H
Product Overview : Human CALB2 full-length ORF (NP_009018.1, 1 a.a. - 179 a.a.) recombinant protein with GST-tag at N-terminal.
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  • Gene Information
  • Related Products
Description : This gene encodes an intracellular calcium-binding protein belonging to the troponin C superfamily. Members of this protein family have six EF-hand domains which bind calcium. This protein plays a role in diverse cellular functions, including message targeting and intracellular calcium buffering. It also functions as a modulator of neuronal excitability, and is a diagnostic marker for some human diseases, including Hirschsprung disease and some cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010]
Source : Wheat Germ
Species : Human
Tag : GST
Molecular Mass : 47.1 kDa
AA Sequence : MAGPQQQPPYLHLAELTASQFLEIW KHFDADGNGYIEGKELENFFQELEK ARKGSGMMSKSDNFGEKMKEFMQKY DKNSDGKIEMAELAQILPTEENFLL CFRQHVGSSAEFMEAWRKYDTDRSG YIEANELKGFLSDLLKKANRPYDEP KLQEYTQTILRMFDLNGDGKLGLSE MSRA
Applications : Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
Notes : Best use within three months from the date of receipt of this protein.
Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
Storage Buffer : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Gene Name : CALB2 calbindin 2 [ Homo sapiens ]
Official Symbol : CALB2
Synonyms : CALB2; calbindin 2; calbindin 2, 29kDa (calretinin); calretinin; CAL2; calbindin D29K; 29 kDa calbindin; calbindin 2, (29kD, calretinin); CR; CAB29;
Gene ID : 794
mRNA Refseq : NM_001740
Protein Refseq : NP_001731
MIM : 114051
UniProt ID : P22676

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Are there any therapeutic strategies targeting CALB2 for neurological conditions? 03/24/2022

While there are no specific drugs targeting CALB2, research into calcium homeostasis modulation and CALB2's role in disease may lead to potential therapeutic avenues.

What is the role of CALB2 in the maintenance of neuronal calcium gradients across subcellular compartments, and how does this impact cellular function? 08/14/2021

CALB2 helps establish and maintain calcium gradients within neurons, ensuring proper functioning of processes such as neurotransmission, dendritic integration, and synaptic plasticity by fine-tuning local calcium concentrations.

How does CALB2 contribute to calcium-dependent gene regulation within neurons at the molecular level? 07/01/2020

CALB2 can interact with transcription factors and co-factors involved in calcium-dependent gene expression, influencing the activation or repression of specific genes in response to changes in intracellular calcium levels.

How does CALB2 function in balancing calcium levels during neuronal activity and synaptic transmission at the molecular level? 01/28/2019

CALB2 dynamically binds and releases calcium ions in response to changes in intracellular calcium concentration, fine-tuning calcium signaling during neuronal activity and synaptic transmission.

In which specific neuronal cell types and brain regions is CALB2 highly expressed? 09/03/2018

CALB2 is abundantly expressed in various neuronal populations, including cerebellar granule cells, interneurons in the cortex, and certain subtypes of neurons in the hippocampus.

Customer Reviews (3)

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Reviews
10/19/2021

    High-quality recombinant proteins boost research productivity.

    06/13/2019

      Ease of use makes them ideal for both novice and expert researchers.

      07/07/2018

        They are essential components of our lab toolkit.

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