Calb1
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Official Full Name
Calb1 calbindin 1
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Overview
Calbindin is a calcium-binding protein belonging to the troponin C superfamily. It was originally described as a 27-kD;protein induced by vitamin D in the duodenum of the chick. In the brain, its synthesis is independent of;vitamin-D-derived hormones. Calbindin contains 4 active calcium-binding domains, and 2 modified domains that;presumably have lost their calcium-binding capacity. The neurons in brains of patients with Huntington disease are;calbindin-depleted. -
Synonyms
CALB1; calbindin 1; calbindin; D-28K; calbindin D28; spot 35 protein; calbindin 1, 28 kD; cerebellar Ca-binding protein spot 35 protein; cerebellar Ca-binding protein, spot 35 protein; vitamin D-dependent calcium-binding protein, avian-type; CaBP28K; MGC93326;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Flag
- GST
- His
- His (Fc)
- Avi
- His|GST
- Myc
- DDK
- MYC
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- Calb1 Related Research Area
Calb1 involved in several pathways and played different roles in them. We selected most pathways Calb1 participated on our site, such as Endocrine and other factor-regulated calcium reabsorption, which may be useful for your reference. Also, other proteins which involved in the same pathway with Calb1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Endocrine and other factor-regulated calcium reabsorption | KLK1B22;DNM3;PLCB3;KLK1B24;KLK1B8;KLK1B26;ATP1B3;BDKRB2;KLK1 |
Calb1 has several biochemical functions, for example, calcium ion binding, protein binding, vitamin D binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Calb1 itself. We selected most functions Calb1 had, and list some proteins which have the same functions with Calb1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| calcium ion binding | MYL6B;CAPN13;FAT2;PNLIPRP2;EFCAB3;MMP24;DNASE1L3;MCTP1;PCDHB6 |
| protein binding | HCK;PXMP2;GPAA1;ABCC2;COL4A3;SOX14;CINP;CLNS1A;TRIM3 |
| vitamin D binding | GC;CALB1;S100G;VDRA |
| zinc ion binding | MSRB2;UQCRC1;LIMS1;ZDHHC16A;UQCRC2B;BRAP;TRAF3;RNF121;LIMA1 |
Calb1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Calb1 here. Most of them are supplied by our site. Hope this information will be useful for your research of Calb1.
IKBKG; TRPV5; CASP3; TRPV6; IQCB1
- Q&As
- Reviews
Q&As (5)
Ask a questionCALB1 is highly expressed in specific populations of neurons, such as Purkinje cells in the cerebellum and certain interneurons in the cortex and hippocampus.
CALB1 can influence neuronal excitability by buffering calcium ions and modulating the activity of calcium-dependent signaling pathways, which can impact synaptic transmission and plasticity.
CALB1 helps maintain precise calcium concentrations in neuronal compartments, ensuring proper calcium signaling and preventing calcium-induced cell damage.
CALB1 dysregulation can disrupt calcium homeostasis, leading to altered neuronal signaling, impaired synaptic plasticity, and increased susceptibility to excitotoxicity.
CALB1 possesses EF-hand calcium-binding motifs that undergo conformational changes upon calcium binding, allowing it to tightly and specifically bind calcium ions.
Customer Reviews (3)
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Reliable purity minimizes experimental variability.
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