Recombinant Human SUMO1, His-tagged

• Cat.No.: SUMO1-249H
• Product Overview: Recombinant human SUMO1 (UBL1) (2-97) was expressed in E. coli cells using an N-terminal His tag.

Specification

• Description: SUMO1 (also known as UBL1) is a member of the SUMO (small ubiquitin-like modifier) protein family which functions in a manner similar to ubiquitin. SUMO1 is bound to target proteins as part of a post-translational modification system and it is involved in a variety of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability. SUMO1 may be involved in the repair of TOP1-mediated DNA damage. The sumoylation pathway plays a significant role in mammalian DNA damage response.
• Source: E. coli
• Species: Human
• Tag: His
• Form: Recombinant protein stored in 50mM sodium phosphate, pH 7.0, 300mM NaCl, 150mM imidazole, 0.1mM PMSF, 0.25mM DTT, 25% glycerol.
• Molecular Mass: ~19 kDa
• Purity: >90% by densitometry
• Applications: Western Blot
• Storage: Store product at –70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
• Concentration: 0.1 μg/μl

Gene Information

• Gene Name: SUMO1 SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae) [ Homo sapiens ]
• Official Symbol: SUMO1
• Synonyms: SUMO1; SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae); SMT3 suppressor of mif two 3 homolog 1 (yeast) , ubiquitin like 1 (sentrin) , UBL1; small ubiquitin-related modifier 1; GMP1; OFC10; PIC1; SMT3C; SMT3H3; SUMO 1; sentrin; SMT3 homolog 3; GAP modifying protein 1; ubiquitin-like protein UBL1; ubiquitin-like protein SMT3C; ubiquitin-homology domain protein PIC1; DAP1; SMT3; UBL1; SENP2
• Gene ID: 7341
• mRNA Refseq: NM_001005781
• Protein Refseq: NP_001005781
• MIM: 601912
• UniProt ID: P63165
• Chromosome Location: 2q33
• Pathway: Cytokine Signaling in Immune system, organism-specific biosystem; Diurnally regulated genes with circadian orthologs, organism-specific biosystem; Immune System, organism-specific biosystem; Interferon Signaling, organism-specific biosystem; Interferon gamma signaling, organism-specific biosystem; Nuclear pore complex, organism-specific biosystem; RNA transport, organism-specific biosystem
• Function: protein binding; ubiquitin protein ligase binding

Reviews

05/07/2022

Swift protein expression optimization, boosts our research efficiency.

11/30/2021

Accurate protein structural characterization, vital for our studies.

02/03/2018

High-quality protein sequencing, invaluable for our work.

Q&As

How do alterations in SUMO1 expression or conjugation affect cancer development and progression?

Changes in SUMO1 expression or activity can contribute to cancer development, affecting tumor cell behavior and environment.

How does SUMO1 modification affect the stability and function of target proteins?

SUMO1 modification alters target protein stability and function, affecting various cellular processes.

What role does SUMO1 play in regulating gene expression and chromatin organization?

SUMO1 regulates gene expression and chromatin structure, influencing transcriptional activity.

How does SUMO1 influence the DNA damage response and repair processes?

SUMO1 is involved in the DNA damage response, aiding in DNA repair and maintaining genomic integrity.

What is the impact of SUMO1 on cellular stress responses, particularly in neurodegenerative diseases?

SUMO1 impacts cellular stress responses, playing a significant role in neurodegenerative disease mechanisms.

How does SUMO1 contribute to the regulation of cell cycle progression and apoptosis?

SUMO1 modulates cell cycle progression and apoptosis, contributing to cell survival and turnover.

What are the mechanisms by which SUMO1 modulates signal transduction pathways, especially in immune responses?

SUMO1 influences signal transduction, particularly in immune cell signaling and response.