Recombinant Zebrafish ARPC4

• Cat.No.: ARPC4-11585Z
• Product Overview: Recombinant Zebrafish ARPC4 full length or partial length protein was expressed.

Specification

• Source: Mammalian Cells
• Species: Zebrafish
• Tag: His
• Form: Liquid or lyophilized powder
• Endotoxin: < 1.0 eu per μg of the protein as determined by the LAL method.
• Purity: >80%
• Notes: This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.
• Storage: Store it at +4 oC for short term. For long term storage, store it at -20 oC～-80 oC.
• Storage Buffer: PBS buffer

Gene Information

• Gene Name: arpc4 actin related protein 2/3 complex, subunit 4 [ Danio rerio (zebrafish) ]
• Official Symbol: ARPC4
• Gene ID: 114456
• mRNA Refseq: NM_205537
• Protein Refseq: NP_991100
• UniProt ID: Q6NZZ2

Reviews

01/15/2021

Renowned for its reliability and consistency, this protein offers researchers the confidence to achieve accurate and reproducible results in their studies.

06/15/2017

One notable advantage of the ARPC4 protein is the excellent technical support provided by its manufacturer.

02/17/2016

The ARPC4 protein is known for its exceptional quality, making it a highly suitable choice for meeting diverse experimental needs.

Q&As

Can ARPC4 expression be regulated by extracellular signals?

Yes, ARPC4 expression can be influenced by extracellular signals. Various signaling pathways, such as the Rho GTPase pathway and growth factor signaling, can activate or inhibit the expression of genes encoding ARPC4 and other subunits of the ARP2/3 complex, thereby modulating actin cytoskeleton dynamics.

Are there any known drugs or compounds that can modulate ARPC4 activity?

At present, there are no specific drugs or compounds known to directly modulate ARPC4 activity. However, targeting actin cytoskeleton dynamics and actin regulatory proteins that indirectly affect ARPC4 function has shown potential in preclinical studies as therapeutic approaches for various diseases.

Are there any diseases associated with mutations in the ARPC4 gene?

Mutations in the ARPC4 gene have not been directly linked to any specific diseases. However, dysregulation of the ARP2/3 complex, including ARPC4, has been implicated in several pathological conditions such as cancer metastasis, neurological disorders, and immune system dysfunction.

Is ARPC4 expression specific to certain cell types or tissues?

ARPC4 is considered a ubiquitously expressed protein, meaning it is expressed in a wide range of tissues and cell types throughout the body. Its expression is necessary for essential cellular processes involving actin cytoskeleton dynamics.

Are there any known interacting proteins with ARPC4?

Yes, ARPC4 interacts with other subunits of the ARP2/3 complex, including ARPC1, ARPC2, ARPC3, ARPC5, and ARPC6. Additionally, ARPC4 can interact with actin-binding proteins, such as cortactin and coronin, which regulate actin filament assembly and stability.

Can changes in ARPC4 expression levels affect cell migration?

Yes, alterations in ARPC4 expression levels can impact cell migration. The ARP2/3 complex, including ARPC4, is essential for actin filament nucleation and branching, which are crucial for cell motility. Changes in ARPC4 expression can disrupt proper actin cytoskeletal dynamics, impairing cell migration.

Can changes in ARPC4 expression affect cell division?

Yes, changes in ARPC4 expression can impact cell division. The ARP2/3 complex, including ARPC4, is involved in actin-dependent processes during cell division, such as cytokinesis and chromosome segregation. Disruption of ARPC4 expression can lead to defects in these cellular processes.